Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
The Pioneer 10 spacecraft, launched #OTD in 1972, famously carries a gold-anodized aluminum plaque that encodes its origins. The plaque was suggested by science journalist Eric Burgess, designed by Carl Sagan and Frank Drake, and illustrated by Linda Salzman Sagan.
Thiago Carvalho
boosted
RT @bramvandijk88
Loving this review from @jpjhall and others, "How do interactions between mobile genetic elements affect horizontal gene transfer?", with a beautiful illustration <3
https://www.sciencedirect.com/science/article/pii/S136952742300019X
A throwback piece on the Instituto Gulbenkian de Ciencia page about a small workshop that Miguel Soares & I organised on resistance and tolerance in 2010. This was back when most immunologists hearing "tolerance" would think only of T and B cell selection (and the occasional regulatory T cells). I'm a big fan of the small workshop, where everyone discusses unpublished work and feels free to speculate. We need more of these meetings.
https://gulbenkian.pt/ciencia/news/scientists-retreat-gave-away-new-era-fight-against-infections/
Thiago Carvalho
boosted
Well, here is a life restoration of the strange Propyrotherium. The body proportions follows more or less to Pyrotherium, having in mind that another pyrothere, Baguatherium, have similar proportions in the femur, so probably these animals shared a similar body plan.
“Nós fizemos uma greve de quatro dias no sentido de que alguém nos oiça e até agora não tem havido qualquer reacção por parte do ministro das Infraestruturas [João Galamba] e das Finanças [Fernando Medina]. Não houve até à data e vamos no quarto dia de greve. Não se percebe como é que não há um pequeno esforço das tutelas para chegar a um acordo”, disse.'
Thiago Carvalho
boosted
#IDMastodon @thelancet The efficacy of #SARSCoV2 #COVID19vaccines is higher for preventing severe infection & death than for preventing milder infection. Vaccine efficacy wanes over time but can be enhanced by a booster. Differences in efficacy of different SARS-CoV-2 full vaccinations on preventing infections of different severity, according to vaccine types
https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(22)00390-1/fulltext
"To engineer durable vaccines, we must first define the rules and features of durable protection. These rules may differ for each virus, platform and between prime and boost responses."
'By investigating acid-sensing ion channel gene expression in each of the three major bilaterian lineages, we see that ASICs are principally found: centrally, in the brain; and/or peripherally, in the digestive system, peripheral nerve rings, and/or scattered peripheral cells.'
Thiago Carvalho
boosted
RT @Faulkner_Lab
Very recent @genomeresearch functional genomics study of ERV enhancers in human trophoblast cells reveals new TF/ERV binding combinations (beyond e.g. STAT1/MER41) that appear to regulate genes essential to placenta development.
https://genome.cshlp.org/content/early/2023/02/17/gr.277150.122.full.pdf+html
1/n
Thiago Carvalho
boosted
RT @morethanadodo
2023 marks the 200th anniversary of the birth of Alfred Russel Wallace (1823-1913), the trailblazing biologist, geographer, explorer, and naturalist.
We’ve been working hard in the archives to bring you something special to celebrate…
Thiago Carvalho
boosted
RT @LMachesky
Delighted to start recruiting postdoctoral RA positions for my new CRUK Programme!! Please reach out if you are interested! #postdocposition @CamBiochem
Thiago Carvalho
boosted
#CardioMastodon Lipoprotein #metabolism in #Dyslipidemia & the Roles of APOC3 & ANGPTL3 in Clinical Development of APOC3 Inhibitors .+ve relationship between increased levels of circulating triglycerides & #CVD has been observed for decades. Driven by genetic cohort studies, inhibitors of APOC3 &ANGPTL that reduce circulating triglycerides are poised to enter clinical practice.
https://www.ahajournals.org/doi/10.1161/ATVBAHA.122.317966
"The Origami Maps (Dresden, 1914-1918)
These maps, or objects, represent the sole known instance of an attempt at creativity by the Margrave. Like so many Europeans of his generation, von Willebrand was enthralled by Japanese art, and he developed a particular fascination with origami – a set of techniques with ancestral origins in Japan whose basic principles influenced the “folds of truth, folds of life and folds of beauty” ideas of German pedagogue Friedrich Fröbel.
Tragically, von Willebrand brought his newfound creativity to bear on the problems of cryptography – the Margrave was ever mindful of his duty to the Fatherland. von Willebrand’s work on the tactical applications of origami in the battlefield somehow managed to pique the interest of the Kaiser’s father, Frederick III, during his brief 99-day reign. When Frederick died, his relationship with the Margrave ultimately led his son Kaiser Wilhelm II to authorize a field test of the origami system during the Third Battle of Ypres. As a result, an entire German reconnaissance platoon was picked off one by one by a perplexed British sniper as they tried to fold paper while wearing full anti-gas gear." https://madalenaparreira.com/SPAM #maps #print #origami #origamiart #printmaking #handmade
An analysis of #LongCovid cases among cancer patients at MD Anderson Cancer Center.
#covid19 #covid
Thiago Carvalho
boosted
Happy to report our paper on the role of Drosophila AMPs in aging is now accepted in Disease Models and Mechanisms (DMM, from @Co_Biologists)! 🥳
We first submitted to @ReviewCommons, which received mixed reviews. We took those reviews to DMM, admittedly disagreeing with some comments. Ultimately, we came to an understanding with both the reviewers and editor, but it was nice to know if things hadn't worked out, we could take our reviewed manuscript to another journal 🙂
Thiago Carvalho
boosted
@cyrilpedia interesting. reminds me of thomas kuhn’s description of “paradigm shifts” in science
@colehaddon It's a breeze to read - perhaps with one of these in hand
@colehaddon Tucci's food memoir, Taste, is a lovely book (with some great recipes)
Thiago Carvalho
boosted
As part of our ongoing SARS-CoV2 Receptor Binding Domain series, below is a 3D print of the SARS-CoV1 RBD. This model was used to compare against SARS-Cov2, RATG13, and the Pangolin Virus receptor binding domains for insights about subsequent mutations.
https://biologicmodels.com/pdb/5x58/sars-cov1-spike-glycoprotein-5x58/
Haruki Murakami on originality in art & literature (from "Novelist as a Vocation".
#books #writers #bookshelf #literature
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
