Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
For Robert Aldrich, unforgettably, she was Milly in #AutumnLeaves (1956) and Blanche in #WhatEverHappenedToBabyJane? (1962). To the world, she was the legendary, Oscar-winning #JoanCrawford
(1906-77), born in San Antonio #OnThisDay.
#BornOnThisDay #BOTD #OTD #GoldenEraHollywood #FilmNoir #HagHorror
2/2
Alternative lifestyles
"Turns out, B. compniacensis spores are widespread but the fungus does not outgrow its microbial neighbors unless there's ethanol in the air. It's been long known that some 2% of the ethanol in distilled spirits evaporates yearly during aging in barrels, this portion generally referred to as the Angel's Share. Not surprisingly, B. compniacensis is generally called the Angel's Share fungus: it has the striking ability to grow on ethanol vapors."
https://schaechter.asmblog.org/schaechter/2023/03/a-whiff-of-taxonomy-baudoinia-compniacensis.html
@achterbrain A great way for future AIs to remember and commemorate humans :)
Thiago Carvalho
boosted
Many museums 🏛 are focused on (histories of) human artifacts 🏺🗿.
As intelligent artificial agents become influential in society, will we see these museums also documenting the evolving cognition of artificial agents?
Papers like this lay the groundwork:
https://arxiv.org/abs/2303.12712
Immune suppression with steroids is of course a part of the classical clinical armamentarium - two things are interesting here on this (mouse) cytokine release syndrome (CRS) paper: at the basic level, it explores an analogous physiologic regulatory circuit; in terms of clinical potential, it shows good effects (in mice) of low dose pretreatment - a viable option for CRS, as it is often caused by a clinical intervention.
"Mice treated with CD3 antibodies were protected against lethal CRS by the production of glucocorticoids (GC) induced by the adrenal stress response in a manner dependent on the scavenger receptor B1 (SR-BI), a receptor for high-density lipoprotein (HDL). Mice with whole-body or adrenal gland-specific SR-BI deficiency exhibited impaired GC production, more severe CRS, and increased mortality in response to CD3 antibodies."
Thiago Carvalho
boosted
A Whiff of Taxonomy – Baudoinia compniacensis
by Roberto
Several of our past posts described volatile organic compounds of microbial origin that influence our behavior. Acetates from wine, geosmin from soil. Not only are they enjoyable in the moment, such scents often elicit memories. I now offer the opposite perspective...
Read more → https://schaechter.asmblog.org/schaechter/2023/03/a-whiff-of-taxonomy-baudoinia-compniacensis.html
@ct_bergstrom There's a good piece in the FT today about the level of private control over the development of these tools. It shows not just a concentration, but how the scale of investment and proprietary nature of the tech put it largely beyond researchers & regulators ability to investigate the dangers and biases.
"A lack of access means researchers cannot replicate the models built in corporate labs, and can therefore neither probe nor audit them for potential harms and biases very easily."
https://www.ft.com/content/e9ebfb8d-428d-4802-8b27-a69314c421ce
Thiago Carvalho
boosted
The confluence of this technology with the information ecosystem that we described in our paper from a couple of years could be an epistemic catastrophe.
https://www.pnas.org/doi/10.1073/pnas.2025764118
I’m coming to think that releasing these tools was a reckless act with the potential to generate negative externalities we have barely started to imagine.
The threat isn’t rogue superintelligence. It’s bullshit at unprecedented scale, reflected back upon itself and iteratively amplified.
Thiago Carvalho
boosted
As part of our ongoing SARS-CoV2 Receptor Binding Domain series, below is a 3D print of the SARS-CoV1 RBD. This model was used to compare against SARS-Cov2, RATG13, and the Pangolin Virus receptor binding domains for insights about subsequent mutations.
https://biologicmodels.com/pdb/5x58/sars-cov1-spike-glycoprotein-5x58/
Thiago Carvalho
boosted
Ever wondered how many symptoms make up all of adult psychopathology described in the DSM-5? It’s 628!
How many do you think repeat across multiple diagnoses? If you answered 231 symptoms repeating a total of 1022 times (median 3 times per symptom, range 2-22), good job!
🧵
Thiago Carvalho
boosted
So Jamie Uhrig is my hero. This is what medicine and public health is. Speaking out for your patients, for the health of the marginalized. Wish others in our fields had half the courage he does. https://www.nydailynews.com/new-york/nyc-crime/ny-rikers-doctor-banned-slamming-correction-department-to-sue-nyc-20230320-vonrg4eeqreibbpuzdd7tua3ei-story.html
FENS – Chen Institute – NeuroLéman Summer School on “Motor control: from thought to action”
Lausanne
02—8 Jul 2023
Registration Deadline: 24 Mar 2023
Thiago Carvalho
boosted
T cell-based therapies can cause cytokine release syndrome (CRS), a potentially lethal cytokine storm. Steroids and blocking antibodies usually help, but not all patients respond. Guo et al. found that mice with a defective adrenal stress response had a high risk for lethal CRS. However, pretreatment with low-dose steroids protected the mice, suggesting that pretreating patients with relative adrenal insufficiency with steroids may prevent lethal CRS. https://www.science.org/doi/10.1126/scisignal.add4900 #science #immunology
Thiago Carvalho
boosted
4 YEAR OLD: I can't sleep, Daddy. I'm afraid of Frankenstein.
ME: Don't you mean Frankenstein's monster?
4 YEAR OLD: I do not. Personally, I find unethical and irresponsible scientific practice far more terrifying than any monster and so should you.
Thiago Carvalho
boosted
New lecturer opportunity in my dept (@EP_UCL):
---
RT @nicholaraihani
🚨Job🚨 Lecturer in Experimental Psychology (3-Year) This is a great opportunity for an early ish career researcher who wants to transition to a fellowship / PI position. Seeking people with interests / expertise in social evolution broadly defined. https://www.ucl.ac.uk/work-at-ucl/search-ucl-jobs/details
https://twitter.com/nicholaraihani/status/1638601284491042817
"Seven puppeteers who operated from “Life of Pi” shared the Olivier Award for best supporting actor in 2022.Credit...Hiroko Masuike/The New York Times"
https://www.nytimes.com/2023/03/21/theater/life-of-pi-tiger-puppet.html
"While advanced language-generating systems and chatbots have dominated news headlines, private AI companies have quietly entrenched their power. Recent developments mean that a handful of individuals and corporations now control much of the resources and knowledge in the sector — and will ultimately shape its impact on our collective future."
https://www.ft.com/content/e9ebfb8d-428d-4802-8b27-a69314c421ce
Thiago Carvalho
boosted
But, soft! What light through yonder window breaks?
Thiago Carvalho
boosted
RT @nicholaraihani
🚨Job🚨 Lecturer in Experimental Psychology (3-Year) This is a great opportunity for an early ish career researcher who wants to transition to a fellowship / PI position. Seeking people with interests / expertise in social evolution broadly defined. https://www.ucl.ac.uk/work-at-ucl/search-ucl-jobs/details
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
