Thiago Carvalho @cyrilpedia@social.cleverlibre.org

"Funding uncertainty from the federal government and uneven commitments from state health departments have raised the specter that wastewater monitoring programs may shut down in the future."

#publichealth #COVID

https://www.scientificamerican.com/article/a-valuable-early-warning-system-for-disease-outbreaks-could-be-shut-down/?utm_source=newsletter&utm_medium=email&utm_campaign=today-in-science&utm_content=link&utm_term=2023-03-30_featured-this-week&spMailingID=72825164&spUserID=MTEyNzc3Mzc0NDY4S0&spJobID=2322705485&spReportId=MjMyMjcwNTQ4NQS2

'This mendelian randomization study suggests that PCSK9 is implicated in psoriasis pathogenesis, and its inhibition is associated with reduced psoriasis risk. These findings potentially pave the way for future studies that may allow personalized selection of lipid-lowering drugs for those at risk of #psoriasis.'

https://jamanetwork.com/journals/jamadermatology/fullarticle/2800634?guestAccessKey=3aed40ad-0631-484f-a639-f3f6e33f2767&utm_source=linkedin_company&utm_medium=social_jamaderm&utm_term=9174110788&utm_campaign=article_alert&linkId=205542175

@cientounero Stop biting iguanas!

RIP Avrion Mitchison.

"Av initiated a series of experiments that collectively provided the conceptual framework of much of today’s understanding of immune rejection, tolerance and T–B cell co-operation."

https://www.nature.com/articles/s41590-023-01461-w

Metabolomics approaches for immunology (review)

"First, this review compares targeted and untargeted metabolomics and reviews recent advances in metabolomics workflows, including sample preparation, raw spectra data preprocessing, metabolomics data processing, statistical analysis, and interpretation. Second, we introduce various computational tools for multiomics data integration and show how recent studies have applied metabolomics in combination with other omics approaches to immunological research. Finally, we discuss new developments in metabolomics and their potential for further research in immunology."

https://www.embopress.org/doi/full/10.15252/embr.202255747

"One thing is certain: you can’t be a momfluencer without kids. Or without pushing those kids into the public eye – handing them on a digital platter to ever-ravenous spectators hankering for access. And you can’t be a momfluencer without putting your kids to work."

https://aeon.co/essays/why-arent-children-protected-from-their-parents-monetising-them

"Spain is to trial a new science funding programme, which will provide researchers with stable funding for four years to explore new ideas and build capacity, without being tied to specific projects. If all goes well, up to €700 million a year in supplementary funding will be available by 2033."

https://sciencebusiness.net/news/International-news/spain-pilot-flexible-open-ended-funding-researchers

'In this review, we provide an overview of mouse genetic reference panels and the opportunities they provide for the study of cardiometabolic diseases and relevant traits, with particular emphasis on the Hybrid Mouse Diversity Panel (HMDP)'

https://elifesciences.org/articles/86139

'The heart-focused company says that its ALS candidate, reldesemtiv, was ineffective in a phase 3 trial compared to placebo after a second interim analysis, according to an announcement Friday. The data monitoring committee recommended that the trial be discontinued and Cytokinetics says it will stop treating people with the drug, including patients in the open-label extension. '

https://www.fiercebiotech.com/biotech/cytokinetics-pipeline-tumble-continues-after-als-med-flops-phase-3-interim-look

@dgar cc @victoralab

"The story of her leadership of the Medicines and Healthcare products Regulatory Agency is of two huge imperatives — first, to chart a new path for the agency after Brexit forced it to leave the embrace of the European Medicines Agency, then to set the international pace in approving life-saving Covid vaccines and therapeutics."

https://www.ft.com/content/3907db25-5cca-4191-8158-56fd4e335e3f