Thiago Carvalho @cyrilpedia@social.cleverlibre.org

"Thus, we performed a comprehensive screen of TE-chimeric transcripts across 10,357 tumors, 675 cancer cell lines and 11,686 Genotype-Tissue Expression (GTEx) adult tissues, and evaluated these TE-chimeric candidates for tumor specificity, antigenic potential, proteomic validation, HLA presentation and membrane presence."
#TumorImmunology #immunology

https://www.nature.com/articles/s41588-023-01349-3

"These differences in expression necessarily limit the usefulness of these systems in identifying and understanding the more subtle roles played by ACE2 in the development and resolution of COVID-19. To overcome these limitations, we have developed two mouse lines in which the ACE2 locus has been humanized by syntenic replacement."

#SARSCoV2
#Covid19

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011168

'It is hoped that a spatially resolved picture of protein expression, posttranslational protein modifications, cell phenotypes, and communities of cell phenotypes will not only advance our understanding of tumor evolution (3) but also guide patient treatment response prediction modeling and the development of novel cancer therapeutics targeting the TME, such as bispecific T-cell engagers, immune-checkpoint inhibitors (ICI), and chimeric antigen receptor (CAR) T cells.'

https://aacrjournals.org/cancerdiscovery/article/13/4/824/725006/Moving-Spatially-Resolved-Multiplexed-Protein

"Two concurrent outbreaks of the Marburg virus, a close cousin of Ebola that can kill as many as 90 percent of the people it infects, are raising critical questions about the behavior of this mysterious bat-borne pathogen and global efforts to prepare for potential pandemics."

#Marburg #Outbreak #publichealth #virology

https://www.nytimes.com/2023/04/03/health/marburg-outbreak-vaccine-treatment.html

Nobelist Martin Chalfie on how *not* to apply for a postdoc:

"They say 'Here is my CV and I'd really like to work in your lab, do you have any space? That's a letter that could be sent out to a hundred people, or a thousand people. There's nothing in it."

https://www.youtube.com/watch?v=x2fBwH6CupA

"The Federal Trade Commission has ordered Illumina to divest cancer screening company Grail, arguing the $8bn acquisition would damage competition in the US market for life-saving cancer tests."

https://www.ft.com/content/3848cf02-8d00-4286-ab96-f3d72bde3c8e

"The prolific chemist, who has published a study every 37 hours this year, has been sanctioned by the University of Córdoba over his research work for other institutions in Russia and Saudi Arabia"

https://english.elpais.com/science-tech/2023-04-02/one-of-the-worlds-most-cited-scientists-rafael-luque-suspended-without-pay-for-13-years.html

'Ben Barres Early Career Acceleration Awards. This is an investigator award for early career academic investigators, especially those who are new to the field of neurodegeneration. Awards are $1.2M in total costs over 4 years. Early career investigators will benefit from mentored support and resources of the CZI Neurodegeneration Challenge Network.'

https://chanzuckerberg.com/rfa/ben-barres-early-career-acceleration-awards/