Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
Network lesion approaches?
Network lesion approaches strike me as pretty remarkable https://www.nejm.org/doi/10.1056/NEJMra1706158. For the aficionados: anything I should be wary about? Any cases in which it didn't lead but misled?
The gist behind them is that you gather together a group of patients with similar symptoms (like Capgras - the delusion that familiar people or things have been replaced by imposters). Next, you use anatomical MRI to pinpoint where the lesions are in their brain. The problem is that it's a bit hard to make sense out of it all. So using healthy controls, you study the network of brain areas that are functionally connected to those lesioned areas to test the hypothesis that symptoms emerge from sites functionally connected to a lesion location, not just the lesion location itself. If the same regions come up again and again across all patients, you might be onto something. You can also test hypotheses about the degree to which those regions overlap with functions you hypothesize to be involved (like brain areas involved in "familiarity" and such).
The approach has been used for all sorts of things, from depression and amnesia to Capgras and even free will:
https://www.pnas.org/doi/10.1073/pnas.1814117115
Thiago Carvalho
boosted
Whenever I read the term "ganglionic eminence"...
Philadelphia’s 'Matisse in the 1930s' show is in Paris (l’Orangerie), will open in Nice in the summer.
'The exhibition fascinates as the first ever to focus on Matisse in this decade, for its optimistic account of renewal by an artist in his sixties and for European audiences as a rare chance to encounter tremendous paintings acquired by Americans.'
https://www.ft.com/content/4a5b1c3c-9e8c-4973-8fed-5bc9b0ec055a
@NicoleCRust And thank you for the kind comments.
@NicoleCRust Thanks for that WP link, I had not seen it. Interestingly, somnolence is one of the most frequent side effects om both Brexanolone and zuranolone trials (and lack the anti-depressive effect, it shows a huge placebo effect). It might also be linked to one of the secondary endpoints in the trials (which they hit), anxiety reduction.
Thiago Carvalho
boosted
@cyrilpedia
I love these columns; thank you. Wonderful to see a new pathway targeted for depression!
One of the things I found striking about the brexanolone trials was the unexpected (but not surprising) discovery that big benefits follow when new moms getting some sleep (ie nothing is in the IV at all):
https://www.washingtonpost.com/wellness/2022/12/09/pregnancy-depression-postpartum-sleep/
Do you know if this was also considered in the zuranolone trials as well? It's a pill - so new moms don't need to check out in the same way (big advantage). But if it works via GABA_A and what happens is that they sleep more, well ...
'There are still plenty of heated controversies among archaeobiologists. “We argue about everything—the timing, the motivation, whether humans were unwitting bystanders or even tricked into it by plants,” says Zeder. But a big-picture view is coming into focus.'
Thiago Carvalho
boosted
A new #preprint #OpenScience #PeerReview by #PCI_Ecology: Charberet, S., Maria, A., Siaussat, D., Gounand, I., & Mathieu, J. (2023). Feeding and growth variations affect δ13C and δ15N budgets during #ontogeny in a #lepidopteranlarva. #bioRxiv #Ecology. https://doi.org/10.1101/2022.11.09.515573
Thiago Carvalho
boosted
RT @NASEM_Health
.@cdc’s new report shows sexually-transmitted infections #STI cases continue to rise, making STI prevention and other forms of sexual health more important than ever: https://www.cdc.gov/std/statistics/2021/default.htm (1/2)
Thiago Carvalho
boosted
When Fisher explained haplodiploidy to Crick in October 1954.
My latest Clinical Pipeline column for #NatureMedicine is a look at zuranolone, a new antidepressant developed by Sage & Biogen, targeting the GABA pathway.
#drugdiscovery #drugdevelopment #depression #GABA #neuroscience
'The Portuguese Heritage Society estimates that up to 90 percent of Portuguese Americans descend from the Azores.'
"Uno de los planes del proyecto UnCan es afinar la hoja de ruta para crear un centro europeo de datos sobre cáncer con aportaciones de todos los países: la información biomédica se integrará con otro tipo de datos, como observaciones geográficas o de estilo de vida, para ponerlos a disposición de la comunidad científica y avanzar en la comprensión de la enfermedad desde todas las aristas posibles."
Thiago Carvalho
boosted
RT @KevinWNg
Excited to share our work on B cells in lung cancer, published today in @Nature!
'The burden of navigating Covid’s risks now falls on the individual, and what “post-pandemic” means for one person or community, like Ninety-Fifth Street Elementary, looks wildly different than it does for others.'
'We show here that in vitro exposure to SARS-CoV-2 activates the expression of the human endogenous retrovirus (HERV) HERV-W proinflammatory envelope protein (ENV) in peripheral blood mononuclear cells from a subset of healthy donors, in ACE2 receptor and infection-independent manner.'
https://www.cell.com/iscience/fulltext/S2589-0042%2823%2900681-8
'Thus, identifying the subset of patients for whom public neoantigens are relevant targets is a major challenge. Nevertheless, the ability provided by the expansion of standard-of-care next-generation sequencing to screen patients affords the opportunity for off-the-shelf precision immunotherapies against public neoantigens that would be broadly applicable to many patients and would have tremendous advantages in scalability relative to targeting private neoantigens'
#Immunology #Immunotherapy #TumorImmunology
Thiago Carvalho
boosted
"Two concurrent outbreaks of the Marburg virus, a close cousin of Ebola that can kill as many as 90 percent of the people it infects, are raising critical questions about the behavior of this mysterious bat-borne pathogen and global efforts to prepare for potential pandemics."
#Marburg #Outbreak #publichealth #virology
https://www.nytimes.com/2023/04/03/health/marburg-outbreak-vaccine-treatment.html
Thiago Carvalho
boosted
A great resource for teaching manuscript writing.
"Familiarity with the process of writing a scientific manuscript and receiving peer reviews often leads to a more focused and driven experimental approach as well as a better understanding of the scientific literature. To jump-start this training, we developed a protocol for teaching manuscript writing and reviewing in a course, appropriate for new graduate or upper-level undergraduate students in biology."
https://qubeshub.org/community/groups/coursesource/publications?id=3708&v=1
Thiago Carvalho
boosted
Really exciting program @pezcoller and in a very lovely location. I remember my invitation to @CIBIO_UniTrento so fondly - great students, some of whom I am still in touch with, cool science and fantastic pasta in this lovely small restaurant close to the institute. 👌
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RT @pezcoller
Excited to share the program of 2023 Pezcoller Symposium, with a tremendous lineup of speakers!
Mark it on your calendar:
💡 NEW TECHNOLOGIES FOR STUDYING…
https://twitter.com/pezcoller/status/1646047407568744450
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
