Thiago Carvalho @cyrilpedia@social.cleverlibre.org

The topic of my latest #NatureMedicine Clinical Pipeline column, zuranolone, represents an improvement in both safety & ease of administration over its on its predecessor, brexanolone (which was the first drug approved specifically for postpartum depression in 2019). The case for it in major depressive disorder is more complex.

https://www.nature.com/articles/d41591-023-00032-8

"Maps 6 & 9. The Origami Maps (Dresden, 1914-1918)

These maps, or objects, represent the sole known instance of an attempt at creativity by the Margrave. Like so many Europeans of his generation, von Willebrand was enthralled by Japanese art, and he developed a particular fascination with origami – a set of techniques with ancestral origins in Japan whose basic principles influenced the “folds of truth, folds of life and folds of beauty” ideas of German pedagogue Friedrich Fröbel.
Tragically, von Willebrand brought his newfound creativity to bear on the problems of cryptography – the Margrave was ever mindful of his duty to the Fatherland. von Willebrand’s work on the tactical applications of origami in the battlefield somehow managed to pique the interest of the Kaiser’s father, Frederick III, during his brief 99-day reign. When Frederick died, his relationship with the Margrave ultimately led his son Kaiser Wilhelm II to authorize a field test of the origami system during the Third Battle of Ypres. As a result, an entire German reconnaissance platoon was picked off one by one by a perplexed British sniper as they tried to fold paper while wearing full anti-gas gear."

#prints #Printmaking #cartography #handmade #artmastodon #artgallery #origami #origamiart

https://madalenaparreira.com/SPAM

"These drugs (such as semaglutide, which is Ozempic/Rybelsus/Wegovy) are famous now because of the huge impact they’ve made in the obesity market, and the market is increasing every day. We’re going to have a lot more people taking these drugs, and we may find out a lot more about them in the process."

https://www.science.org/content/blog-post/ozempic-and-other-glp-1-drugs-more-people-realize

"We examine the levels of hate speech and prevalence of
bots before and after Musk’s acquisition of the platform. We
find that hate speech rose dramatically upon Musk purchasing
Twitter and the prevalence of most types of bots increased,
while the prevalence of astroturf bots decreased."

#Twitter

https://arxiv.org/abs/2304.04129

Large European study underlines power of genomic sequencing to diagnose diseases

By: Andrew Joseph

https://www.statnews.com/2023/04/12/large-european-study-underlines-power-of-genomic-sequencing-to-diagnose-diseases/?utm_medium=social&utm_source=mastodon&utm_campaign=mastodon_organic

'Our cross-species study indicates that scaling of cell size to ploidy is not due to abrupt changes in cell division timing, that different size scaling regimes occur during embryogenesis, and that the developmental program of Xenopus is remarkably consistent across a wide range of genome and egg sizes.'

https://www.cell.com/current-biology/fulltext/S0960-9822(23)00161-6

"In this study, we investigated the mechanism that one specific species of microbiota shortens lifespan and disrupts gut homeostasis of the aged flies, using a “fermented” fly diet. We found that the specific effects of this bacterium on fly healthspan were due to its capability of stimulating a specific receptor in the gut that recognizes peptidoglycan, a component of bacterial cell wall. Paradoxically, the same bacterium also increases stress resistance and defence against oral infection of a pathogen."
#Drosophila #Microbiota #ageing

https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010709

Many interesting positions open at PRBB Barcelona, tech, manager, training, postdocs - have a look 👇
#ScienceJobs

https://www.prbb.org/life-prbb.php#Ofertas-empleo

Capt Louis is shocked. Shocked!

"The mogul’s treatment of union organizers and whistleblowers suggested that “free-speech absolutism” was mostly code for a high tolerance for bigotry toward particular groups, a smoke screen that obscured an obvious hostility toward any speech that threatened his ability to make money."

https://www.theatlantic.com/ideas/archive/2023/04/elon-musk-twitter-free-speech-matt-taibbi-substack/673698/

Deadline June 15.

"Applications must be submitted by a consortium composed of 4–6 higher education institutions from eligible countries in Africa and one higher education institution from the EU. The selected consortia will organise activities to implement the mobility of Master and Doctoral level students, trainees (students enrolled in a Bachelor, Master or PhD programme), and academic and administrative university staff within Africa."

https://international-partnerships.ec.europa.eu/news-and-events/news/global-gateway-european-commission-announces-funding-opportunity-academic-mobility-africa-2023-04-05_en

In humans, #D2HGDH mutations cause developmental delay, seizures & #ataxia. Study shows that in nematode #Celegans, D2HGDH sustains #KetoneBody production to support embryonic viability; loss causes #mitochondrial defects & embryonic lethality #PLOSBiology https://plos.io/41r41k4