A large-scale study of mutations in mitochondrial DNA has revealed a subset that does not accumulate with age. https://elifesciences.org/articles/87194?utm_source=mastodon&utm_medium=social&utm_campaign=organic_insights
'Our studies demonstrate that in vivo trans PD-L1/CD80 interactions do exist between T and tumor cells, and in vivo blockade of trans PD-L1/CD80 interactions or general PD-L1/CD80 interactions augment tumor immunity via expansion of IFN-γ-producing CD8+T cells and NOS2+macrophages in the tumor tissues.'
#immunology #immunooncology #immunotherapy #checkpointinhibitors
'Um outro ponto importante, que se coaduna com a estratégia de internacionalização das actividades da Fiocruz, é a possibilidade de a Fiocruz abrir uma filial aqui em Portugal por meio de um escritório ou um laboratório. Instalar fora do Brasil a partir de uma experiência que já teve em Moçambique.'
"Request reviews and feedback for the next preprint that you post by submitting to a review service (such as Peer Community In, eLife, Review Commons, PeerRef, etc) and/or including an explicit invitation to review on the first page of your preprint or other public location. "
https://asapbio.org/advancing-the-culture-of-peer-review-with-preprints-a-call-to-action
The 2023 European Drosophila Board elections are now open! The closing date for voting will be May 19th.
You can vote for candidates in all regions, not just where you are based, by following this link:
'El actual brote de dengue en Argentina es el más letal de la historia en el país sudamericano. Hasta mitad de abril, el número de casos registrados de dengue fue de 56.324 y las muertes ascendieron a 39, según el último Boletín epidemiológico del Ministerio de Salud, publicado este sábado.'
RT @UriAlonWeizmann
Damage dynamics in individual E. coli cells as they age explains why identical cells die at different times.
Amazingly, damage follows a stochastic equation found also in mice. Aging may be universal in its fundamental dynamics. #qbio #aging
http://disq.us/t/4ftdprd
'Philips Respironics, a subsidiary, is facing lawsuits over a faulty component in devices that help people suffering from sleep apnoea to breathe. It has set aside more than €1.1bn to cover the costs of the recall.'
https://www.ft.com/content/3b42213e-ba82-4718-bb4e-f4fbe5f6206d
"The experiments showed that exosomes were not efficient at transporting proteins or RNA."
Taking the tube https://elifesciences.org/digests/84391/taking-the-tube
Richard Avedon and James Baldwin in Harlem, 15 October 1946 © Photograph by Richard Avedon © The Richard Avedon Foundation
https://www.ft.com/content/62a017eb-0ab6-449f-9d06-646c0bd42bc4
Analysis of transcription patterns of risk genes for human #BrainDisease reveals expression signatures across brain anatomy; these can be used to compare & aggregate diseases, providing novel associations @YasharZeighami @HawrylyczMike &co #PLOSBiology https://plos.io/3N2a1Mr
@domhenri Note: two eyes not required to comply.
RT @Lisboa_Antiga
Rua Garrett, 25 Abril 74
Forças lideradas por Salgueiro Maia dirigem-se para o Quartel-General da GNR ao Carmo, onde se encontram Marcelo Caetano e seus ministros.
Fotografia de AD in @dntwit
#Lisboa #Lisbon #photography #Follow #photooftheday #photo #Lissabon #Lisbonne #25abril
Imperial College London launches call for next generation of women scientists from South Asia:
"In partnership with the British Council, Imperial is offering fully funded Early Academic Fellowships to women from Bangladesh, India, Nepal, Pakistan and Sri Lanka to spend up to a year in London"
Extended deadline for submission is Friday 19 May 23.59 (BST).
News: https://www.imperial.ac.uk/news/244192/imperial-launches-call-next-generation-women/
Announcement and application: https://www.imperial.ac.uk/admin-services/international-relations/bcstemeaf/
'After positive results in clinical trials across cancer, metabolic and rare disease treatments, AstraZeneca’s share price has risen 19% in the past year and 140% in the last five years, valuing the company at nearly £189bn. This compares with Pfizer’s $227bn (£182bn).
AstraZeneca is now the largest company listed on the London Stock Exchange.'
Open position in a great department!
Immunology Lecturer in the Department of Microbiology at the University of Tennessee-Knoxville
#OtD 23 Apr 1942, German communist, Olga Benário, died in a Nazi concentration camp, where she was held despite being seven months pregnant. Olga had lived in Brazil as the bodyguard and then wife of Brazilian communist, Luís Prestes https://jwa.org/encyclopedia/article/prestes-olga-benario
Main mechanisms of enterococcal antibiotic resistance
Most commonly due to altered target with⬇️binding
➡️β-lactams: PBP4, PBP5
➡️Vancomycin: D-Ala-D-Lac
➡️Linezolid: 23s rRNA mutations
β-lactamases play no role so BLBLI won't work for Amp-R strains
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com