Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
'She added that the UK was at a “tipping point” in its relationship with the life sciences sector, which has been battling the government over taxes on drug prices, and what it says is a lack of investment in innovation. The number of industry clinical trials in the UK has fallen 41 per cent since 2017.'
https://www.ft.com/content/f20ae6ec-8207-4709-9bf9-99613c76980e
"El riesgo está ahí, y los niveles de vacunación de la Unión Europea pueden no ser suficientes para garantizar la ausencia de brotes, según ha alertado esta semana el Centro Europeo de Control de Enfermedades (ECDC, por sus siglas en inglés)."
@lzvolk I know a lot of drosophila labs that keep fly eating plants.
@lzvolk That's a beautiful bird!
'Não sei se esta é matéria do foro político ou psicanalítico, mas os liberais não conseguem criticar o fascismo sem falar de comunismo e normalmente fazendo uma equivalência entre ambos. Chega o 25 de Abril e veem-se na circunstância de ter de celebrar o fim do fascismo. Claro que não se sentem confortáveis ao fazê-lo sem dizer nada sobre aquilo que verdadeiramente detestam: o comunismo. Nisso são apaixonados. É verdadeiro.'
https://www.publico.pt/2023/04/26/opiniao/opiniao/rui-rocha-lugarcomum-2047426
Thiago Carvalho
boosted
On this day in 1932: Michael Smith was born, won 1993 #NobelPrize for site-directed mutagenesis, a technique to alter specific genes #ThisDayInBiotech
Thiago Carvalho
boosted
Julien Pernier, Marcelina Cardoso Dos Santos, Christophe Le Clainche and colleagues dissect the role of talin and kindlin in integrin clustering, describing their synergistic effects in enhancing cell adhesion.
Highlight: https://journals.biologists.com/jcs/article/136/8/e136_e0801/307156/Talin-and-kindlin-team-up-to-regulate-integrin
Article: https://journals.biologists.com/jcs/article/136/8/jcs260746/307144/Talin-and-kindlin-cooperate-to-control-the-density
This article is associated with Tree no. 368; an oak tree planted in The Young People’s Forest in Derbyshire, managed and maintained by the Woodland Trust
https://forest.biologists.com/landscape/?id=84395
#forbiology #forbiologists
'Dr. Franklin’s early death also meant she missed out on the Nobel Prize, but the Nobel Assembly could have found other ways to acknowledge her contribution, said Nils Hansson, a historian of medicine at Heinrich Heine University Düsseldorf, in Germany. Neither Dr. Watson nor Dr. Crick mentioned her when they accepted their awards, Dr. Hansson noted, although Dr. Wilkins, who also received the prize, did.'
https://www.nytimes.com/2023/04/25/science/rosalind-franklin-dna.html?
Thiago Carvalho
boosted
#YAP/#BRD4-controlled ROR1 promotes tumor-initiating cells and #hyperproliferation in #pancreaticcancer
Masaya Yamazaki et al show that #ROR1 marks an aggressive partial #EMT cell cluster and enhances #PDAC proliferation via c-#Myc/#E2F/#AURKB signaling
Thiago Carvalho
boosted
April 26, 1848, 25-year-old British naturalist, co-discovered of evolution & pioneer of biogeography Alfred Russel Wallace departs the UK to South America, where he will study animals & plants for the next 4 years.
Thiago Carvalho
boosted
'In this review, we will briefly introduce the current treatment paradigms for PDAC and then expand upon the biological underpinnings driving its pathogenesis and progression.'
This is not an aspect of NY that I am thrilled Lisbon is copying so well:
"Still, even before the pandemic there was a steady if not huge flow of people out of New York. Why were they leaving? It probably wasn’t crime, although perceptions can be at odds with reality. It probably also wasn’t taxes; I’ll get there in a minute. The biggest factor, almost surely, was and is the cost of housing."
https://www.nytimes.com/2023/04/24/opinion/new-york-city-affordability-housing.html
Thiago Carvalho
boosted
Positive and Relaxed Selective Pressures Have Both Strongly Influenced the Evolution of Cryonotothenioid Fishes during Their Radiation in the Freezing Southern Ocean https://doi.org/10.1093/gbe/evad049 #science #evolution #biology #genome #SciComm #evolgen_paper
"Getting Franklin’s story right is crucial, because she has become a role model for women going into science. She was up against not just the routine sexism of the day, but also more subtle forms embedded in science — some of which are still present today."
Thiago Carvalho
boosted
'Given the vaccine nationalism seen during COVID-19, and that pandemic treaty negotiations are still nascent, there is a risk that governments, particularly those in high-income countries, will use advance purchase agreements to secure national supply of scarce vaccine resources during a future influenza pandemic.'
'Our data indicate that E2a suppresses leukemogenesis by promoting T cell development and enforcing inter-thymocyte competition, a mechanism that is emerging as a safeguard against thymocyte transformation.'
#Preprint #Immunology #Leukemia
https://www.biorxiv.org/content/10.1101/2023.04.23.537993v1?med=mas
Thiago Carvalho
boosted
'Cancers that pass from one host to another are rare in nature, but can have devastating effects, says study co-author Rodrigo Hamede, a disease ecologist at the University of Tasmania in Hobart. “In a matter of 10 years, we lost between 60–70% of the overall [devil] population,” he says.'
Thiago Carvalho
boosted
'Still, in December, when Elon Musk joked on Twitter that his “pronouns” were “Prosecute/Fauci,” it felt like the cresting of a turning tide against the man who had played essentially that role for the first three years of the pandemic. At least 30 state legislatures have passed laws limiting public-health powers in pandemics.'
https://www.nytimes.com/interactive/2023/04/24/magazine/dr-fauci-pandemic.html
Thiago Carvalho
boosted
'There was no military reason to bomb Gernika. No barracks or munitions factories of significance were to be found there. Nor was the town on the front lines. Politically, people identified it with Basque culture and independence. Attacking it was the equivalent of targeting the Liberty Bell in Philadelphia, but not the navy yard to the south of the city.'
Thiago Carvalho
boosted
'To appreciate this catastrophe, we’ve got to move the focus off humans, at least for a bit. H5N1 is devastating the world’s birds. Eagles are dropping dead, as are great horned owls and peregrine falcons and pelicans. Twenty California condors recently died of what’s suspected to be avian flu — 10 are confirmed so far. It’s the worst thing that has happened to wild birds since the pesticide DDT.'
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
