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"To capture the complex interplay between the tumor antigenic landscape and anti-tumor immunity in lung cancer, we integrated genomics, transcriptomics, immunopeptidomics, spatial transcriptomics and multiplexed immunofluorescence (mIF) imaging to investigate the antigenic landscape in tumors with variable degrees of immune infiltration"

nature.com/articles/s43018-023

Interested in a 𝘀𝗰𝗶𝗲𝗻𝘁𝗶𝗳𝗶𝗰 𝘁𝗿𝗮𝗶𝗻𝗲𝗲𝘀𝗵𝗶𝗽 in a stimulating, multicultural & multi-disciplinary research environment? 👩🏻‍🏫🧑🏽‍💻👨🏼‍💼 👩🏿‍🔬

Applications are open for our scientific traineeship!

𝙅𝙊𝙄𝙉 𝙐𝙎!
👇
europa.eu/!R76dyc

#EUcareers

🐦🔗: n.respublicae.eu/EU_ScienceHub

Termination of STING responses is mediated via #ESCRT- and #ubiquitin-dependent degradation to prevent unwarranted #inflammation
Katherine Balka, Dominic De Nardo et al @monashuni
embopress.org/doi/10.15252/emb

'We demonstrate that while male NK cells display enhanced cellular fitness in mice, they show decreased effector function in mice and humans. These sex biases in NK cell composition and function were not completely due to hormonal differences, because they persisted in gonadectomized mice'

nature.com/articles/s41590-023

'Writing in Nature, Krishna et al.2 show that malignant gliomas can grow by modifying brain circuitry, thus taking cognitive function away from their host and ultimately leading to death. These insights might lead to fundamentally new approaches to glioma treatment and provide a means of limiting cognitive decline in affected individuals.'

nature.com/articles/d41586-023

Mogarraz, Salamanca.

A change of scene. From the film sets near Almeria, we go to this beautiful town of Mogarraz, where the buildings have faces - literally!

Camera: Mamiya M645 1000S
Film: Ilford FP4
Developer: Ilfotec LC-29 1+19 - 7.5 minutes
.

GPS location: google.com/maps/place/40.49223

#photography #believeinfilm #filmphotography #analogphotography #filmisnotdead #blackandwhite #bnw #blackandwhitephotography #monochrome #spain #mogarraz

Biology Open helps researchers promote themselves alongside their papers through our #FirstPerson interview series... This week we showcased Rajeshwari B. R. the first author on ‘ Kinetics of Arf1 inactivation regulates Golgi organization and function in non-adherent fibroblasts’.

journals.biologists.com/bio/ar

Pictures Considered #59: Inside a Choanoflagellate

by Roberto
Choanoflagellates (endearingly referred to as "choanos") are the closest living relative of animals and as such they can provide insights into the evolution of animal multicellularity. Interestingly, at least two choano developmental features are induced by bacterial products.

Read more → schaechter.asmblog.org/schaech

#microbiology #choanos

"#preprints really are communicating the most important parts of the #science as soon as they're ready" says Mark Hanson @MarkHanson, first author of the preprint awarded in the ‘Make your negative result a preprint winner’ competition.

Learn more about the competition, Mark's preprint and the value of the publishing negative results in the blog post asapbio.org/sharing-negative-r

#OpenScience

'A recent American study found that an elite class of principal investigators who hold three or more concurrent NIH (National Institutes of Health) grants grew in number over the past 30 years but, even after controlling for career stage and degree, women were significantly underrepresented. And despite evidence of diminishing returns for annual grants over US$600,000, the dollars remain concentrated in the hands of a select few.'

theguardian.com/commentisfree/

Today was a big day for the lab: we submitted our first real paper!!! 🥳 It's hard to believe we're here and I'm so excited and proud of us.

But this isn't a thread about the paper.
I want to share (esp with my senior colleagues) what it took for us to get from 2020 to here. 1/

@BiologyOpen
and our publisher
@Co_Biologists
offer a number of practical ways to help you meet the unique needs and challenges you may encounter as an #early-careerresearcher (ECR). Visit our dedicated ECR webpage to find out more: biologists.com/about-us/early-
#Research #sciencemastodon #Scicomms

'A single dose of the human papillomavirus vaccine is highly effective at preventing infections over three years, most likely lowering rates of cervical cancer and other diseases linked to the virus, according to a new study in Kenya.'

nytimes.com/2023/05/02/health/

"Personalized genome sequencing has revealed millions of genetic differences between individuals, but our understanding of their clinical relevance remains largely incomplete. To systematically decipher the effects of human genetic variants, we obtained whole genome sequencing data for 809 individuals from 233 primate species, and identified 4.3 million common protein-altering variants with orthologs in human."

biorxiv.org/content/10.1101/20

The Invisible Cities is a book everyone should read.

"No matter how fantastical those places are in Invisible Cities, he reveals that they’re all Venice. They’re all basically Marco Polo riffing about Venice. It’s his childhood home. Calvino touches on the idea of nostalgia, and I think in the ancient Greek sense of nostalgia—in trying to get home, you go off and you have these adventures"

lithub.com/darran-anderson-on-

RT @helenaapinheiro
New cover @NatImmunol depicting NK cell-intrinsic sex differences.
O'Sullivan & Maureen Su Labs @UCLA show that an extra copy of the X-linked epigenetic regulator UTX in female mice increases NK cell effector function in female mice.

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