Thiago Carvalho @cyrilpedia@social.cleverlibre.org

Follow @TexasObserver’s coverqge on the larger aftermath of the Dobb ruling, one year later: https://www.texasobserver.org/topics/public-health/

Referenced link: https://www.nature.com/articles/s42255-023-00829-4.epdf
Discuss on https://discu.eu/q/https://www.nature.com/articles/s42255-023-00829-4.epdf

Originally posted by Nature Portfolio / @NaturePortfolio: http://nitter.platypush.tech/NaturePortfolio/status/1673368796319432704#m

Pairing exercise with a diet-induced weight-loss intervention leads to greater improvement in insulin sensitivity and glucose control than dieting alone in people with obesity and prediabetes, according to a clinical trial published in @NatMetabolism. https://www.nature.com/articles/s42255-023-00829-4.epdf

Last year, we failed to replicate some key experimental results in an extraordinary @eLife paper. Our results, the authors' response, and a correction to the original paper are now published.

https://elifesciences.org/articles/84435
https://elifesciences.org/articles/85370
https://elifesciences.org/articles/90007

My opinion is that the original paper is flawed and should be retracted, but now @eLife readers can hear from both sides and decide for themselves.

#IDMastodon #Viralimmunity @cdcgov
Never too late to get #COVID19vaccines & 😷 #CovidIsNotOver
In this finding Antibodies to the spike protein develop after vaccination or infection and can take a relatively long time to decrease, but antibodies to the nucleocapsid protein develop only after natural infection and wane at a faster rate, which is particularly detectable with testing by using an IgG assay format vs a total antibody assay format

Targeting FGF21 & GLP-1 pathways in NASH. My latest Clinical Pipeline column for Nature Medicine is online.

#drugdiscovery #drugdevelopment #metabolism #LiverDisease #fattyliver

https://www.nature.com/articles/d41591-023-00055-1

Boehringer moves forward with its glucagon/GLP-1 receptor dual agonist, survodutide.

"The German drugmaker is now preparing to launch a late-stage trial of its drug, which if approved, would compete with Eli Lilly’s Mounjaro and Novo Nordisk’s Wegovy. US pharma group Pfizer and biotech Regeneron are among the others hoping to enter the market."

#Metabolism #Pharma #DrugDevelopment #DrugDiscovery #Obesity

https://www.ft.com/content/d3f5e936-05af-4775-8247-cff1c007ba45

"After leaving the field in disgrace, Dr. Hwang has landed in clover, and now spends his days cloning beauty show and racing camels for United Arab Emirates royalty."

https://www.nytimes.com/2023/06/21/opinion/cloning-science-fraud.html

Copying Donatello (no, not the turtle).

"Starting with a pencil sketch before working with a series of ever-finer tools to ‘nibble away’ at the stone, Smith offers an immensely satisfying glimpse into how one of history’s great sculptors created dazzling, emotive scenes from just stone, shadow and light."

https://aeon.co/videos/from-a-pencil-sketch-to-cherubs-dancing-in-stone-recreating-a-donatello-work

'Gramsci es el pensador fundamental para entender por qué mandan los que mandan y por qué obedecen los que obedecen.'

https://elpais.com/ideas/2023-06-25/los-diez-pensadores-que-mas-influyen-en-la-izquierda.html

#OTD 26 June 1913 Aimé Césaire was born. He became an anti-colonial author & politician who coined the word 'négritude.' He founded the Parti progressiste martiniquais in 1958 & served in the French National Assembly from 1958 to 1993.

USG at last is putting serious resources into new Covid vaccine research. But there's a lot of confusion and uncertainty as it gets underway. Ben Mueller, Noah Weiland, and I report here: https://www.nytimes.com/2023/06/26/health/covid-vaccines-nextgen.html

A delegação portuguesa à COP-28 tem a obrigação de aproveitar esta oportunidade histórica e defender uma melhor colaboração e cooperação internacional neste domínio. O acesso a recursos e conhecimento deve ser partilhado. As dinâmicas de poder e as desigualdades históricas que os condicionam devem ser desmanteladas. Estamos juntos no mesmo planeta e a saúde é um bem universal a que todos têm direito

👇👀👇

https://onovo.pt/opiniao/momento-de-viragem-na-relacao-entre-saude-e-ambiente-JG15753831

Celebrating 25 years of the International Brain Bee!
The 2023 IBB World Championship will be held virtually from July 31 to August 5, in conjunction with the #AmericanPsychologicalAssociation convention in Washington, DC. National Brain Bee champions from around the world will come together for an exciting competition and educational social program. www.thebrainbee.org

"Even if this turns out not to be widespread, it’s a good reminder: Malaria could make a comeback in the US, and we — and our public health infrastructure — ought to be prepared. This is especially true as a changing climate and shifting weather patterns increasingly drive mosquito migration into new places worldwide, allowing malaria to settle in where it hasn’t before." #entomology #insects #mosquitoes #malaria #VectorBorneDisease https://www.vox.com/science/2023/6/23/23771154/malaria-transmission-florida-texas-mosquitoes-risk-prevention-anopheles

#^Ola ka honua


Meet the forest that a community brought back to life on the slopes of a volcano in a hopeful story of ecological restoration
- by Aeon Video

Watch at Aeon

“Proper planning, adequate resourcing and swift action saves lives. From the families’ perspectives, the UK had none of those three things.” I’m sympathetic to these views, but here’s a question: who was well prepared, not with hindsight but before the pandemic?'
#publichealth #covid19 #pandemic

https://www.ft.com/content/14324ba2-ae25-4435-b07c-7aad3c49fe23

'Germline hemizygous loss-of-function mutations affecting the actin regulator DOCK11 were shown to cause a previously unknown inborn error of hematopoiesis and immunity characterized by severe immune dysregulation and systemic inflammation, recurrent infections, and anemia.'
#Immunology #humanimmunology

https://www.nejm.org/doi/full/10.1056/NEJMoa2210054?query=featured_home

'The clinic is not just a place where Gaustine treats patients; it is also the perfect conceit for Gospodinov’s narrator to explore the 20th century in Europe through the vanishing points of traumatised or broken individuals. It’s as if Oliver Sacks and WG Sebald had collaborated on a Europe-wide chain of treatment centres.'

https://www.theguardian.com/books/2022/may/20/time-shelter-by-georgi-gospodinov-review-the-dangers-of-dwelling-in-the-past?ref=thebrowser.com