Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
"After getting involved with my postdoctoral association’s advocacy committee, I quickly saw that many incoming postdocs were facing similar troubles. Wanting to do what I could to help, I took on the role of disseminating information about work-life balance and mental health, announcing seminars, meditation sessions, and mental well-being programs."
My new Clinical Pipeline column is out in Nature Medicine.
It's on JAK inhibitors for alopecia - and at the black box safety warning the FDA attached to this entire class of drugs.
Searching for citation relevance.
"Given the interest in distinguishing between substantive vs. rhetorical references, we asked whether it is possible to identify subsets of the citation literature that are unequally associated with substantive vs. rhetorical references. We then sought to use these as training data to build a scalable model that might indirectly identify substantive vs. rhetorical citations."
Thiago Carvalho
boosted
On this day in 2004: Francis H C Crick died. He won the 1962 #NobelPrize for determining double-helix of DNA #ThisDayInBiotech
@mdziemann Congratulations
'Here, we used CRISPR-based loss-of-function screens to identify a markedly limited set of ISGs that confer interferon-mediated suppression of a model alphavirus, Venezuelan equine encephalitis virus (VEEV). We show via combinatorial gene targeting that three antiviral effectors—ZAP, IFIT3, and IFIT1—together constitute the majority of interferon-mediated restriction of VEEV, while accounting for < 0.5% of the interferon-induced transcriptome.'
'In conclusion, mitochondrial perturbation of the epithelium causes dysbiotic expansion of Bacteroides spp., supporting the concept that microbe-host cross-talk contributes to metabolic injury in intestinal inflammation.'
#Preprint #HostPathogen #metabolism #Immunology #MucosalImmunology
Thiago Carvalho
boosted
A woman encounters a winged ghost in this ukiyo-e print by Tsukioka Yoshitoshi (1886) titled 'Mt. Yoshino Midnight Moon' from the series 'One Hundred Aspects of the Moon.'
#JapaneseArt #ukiyoe #yoshitoshi #japan #ghost #ghosts #folklore @folklore
Thiago Carvalho
boosted
Madalena & Jorge, the secret identity of @thehunchbacksociety revealed.
#Art #Ceramics #Stoneware #ArtGallery #Pottery #artists #artmastodon
Thiago Carvalho
boosted
In her #JEB100 ECR Spotlight Kristen Jakubowski tells us how an injury changed her research focus and how her work on what contributes to ankle stiffness could help rehabilitation efforts
https://journals.biologists.com/jeb/article/226/14/jeb246395/324868
Read the full article:
https://journals.biologists.com/jeb/article/226/14/jeb244863/324867
#biomechanics #Biology
Thiago Carvalho
boosted
My new Clinical Pipeline column is out today in Nature Medicine, a look at JAK inhibitors for alopecia - and at the black box safety warning the FDA attached to this entire class of drugs.
Thiago Carvalho
boosted
In this episode of the Epigenetics Podcast, we talked to Claudio Cantù from Linköping University about his work on peak blacklists, peak concordance and when a peak is a peak in CUT&RUN. #chromatin #epigenetics #podcast
Listen here: https://activemotif.com/podcasts#claudio-cantu
Thiago Carvalho
boosted
'20 Essential Classic International Films You Can Watch for Free on YouTube'
This free article offers up a curated collection of twenty international titles I believe are essential experiences for anyone who claims to love film — including French, German, Italian, Japanese, Soviet, and Spanish titles. All are available for free to watch, study, and enjoy.
https://open.substack.com/pub/colehaddon/p/20-essential-classic-international?r=1mimd1&utm_campaign=post&utm_medium=web
#film #movies #cinema #cinephile #internationalfilm #worldcinema #art #culture
At the Whitney.
Florine Stettheimer, New York Liberty (1918/19)
Thiago Carvalho
boosted
'She had consented to be a part of our research project and was determined to contribute — she had told me that it wasn’t every day that a person had electrodes implanted in their brain, and what else was she doing while she waited to have seizures that the epileptologists could track?'
Thiago Carvalho
boosted
The story of the current generation of anti-obesity drugs from early failures with leptin & ghrelin told by one of its pioneers, Matthias Tschöp. A new podcast project, you can listen to "#Obesity is a brain disease" by scrolling down at the link below.
https://www.pioneercampus.org
#science #metabolism #neuroscience #sciencecommunication #sciencepodcast #scicomm
Thiago Carvalho
boosted
@cyrilpedia @NicoleCRust Good find. I have always wondered about this b/c I can barely do 10 minutes of a psychophysics experiment on a good day. I can't even imagine what it's like as a pre-op epileptic with a bunch of hardware in place.
Thiago Carvalho
boosted
However, site 408 is a major focus of antibodies elicited by SARSCoV2 vaccination of humans with prior SARS-CoV-1 infection.
The differences between image shown here & post immediately above illustrate how profoundly immune imprinting shapes antibody specificity.
At first this seems exciting: imprinting w SARS-CoV-1 followed by boosting w SARS-CoV-2 can elicit antibodies that neutralize sarbecoviruses w have ~76% spike protein identity!
But there are caveats when you dig a bit more deeply…
Thiago Carvalho
boosted
The antibodies E7, F1, & F5 cross neutralize both SARS-CoV-2 & animal sarbecoviruses w spike identities of only ~76%, but they have greatly reduced neutralization against newer SARS-CoV-2 variants (like XBB) even though XBB has >96% spike amino-acid identity to early SARS-CoV-2.
My new Clinical Pipeline column is out today in Nature Medicine, a look at JAK inhibitors for alopecia - and at the black box safety warning the FDA attached to this entire class of drugs.
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
