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1985 | Franz Hillenkamp and his colleague Michael Karas used a LAMMA 1000 mass spectrometer to demonstrate the technique of matrix-assisted laser desorption/ionization (MALDI) | #proteomics

Douglas Adams: "The major problem—one of the major problems, for there are several—one of the many major problems with governing people is that of whom you get to do it; or rather of who manages to get people to let them do it to them.
To summarize: it is a well-known fact that those people who must want to rule people are, ipso facto, those least suited to do it.
To summarize the summary: anyone who is capable of getting themselves made President should on no account be allowed to do the job."

A reminder to submit your symposium proposal for the 3rd Joint Congress on Evolutionary Biology, to be held in Montreal in July 2024. The Joint Congress will bring together researchers from the European Society for Evolutionary Biology, the Society for the Study of Evolution, the American Society of Naturalists, and the Society of Systematic Biologists. (1/2)

Every time I write about the dangers of pickup trucks, I get attacked in hundreds of tweets and comments as a leftist looney. I hope it is more civil on Mastodon! But it is past time they were regulated, particularly in cities. lloydalter.substack.com/p/its-

Mary Frances Winston Newson was born #OTD in 1869.

She became the first female American to receive a PhD in mathematics from a European university, namely the University of Göttingen in Germany. She was also the first person to translate Hilbert's problems into English.

Hilbert put forth a most influential list of 23 unsolved problems at the International Congress of Mathematicians in Paris in 1900. via @wikipedia

#books #mathematics

It's summer in Portugal, so we are required by law to grill sardines.

'Much guidance on statistical training in STEM fields has been focused largely on the undergraduate cohort, with graduate education often being absent from the equation. Training in quantitative methods and reasoning is critical for graduate students in biomedical and science programs to foster reproducible and responsible research practices.'

journals.plos.org/ploscompbiol

Toto, I've a feeling we're not in New York anymore.

Cork, right after the harvest.

'Our results show that despite different building materials, comb configurations, and 179 million years of independent evolution, honey bees and social wasps have converged on the same solutions for the same architectural problems, thereby revealing fundamental building properties and evolutionary convergence in construction behavior.'

journals.plos.org/plosbiology/

I found the perfect sign to go over this #caricature painting of Edgar Allan Poe by @TealCartoons.

Want to replicate this look? Adrian currently has limited edition signed prints - which are on sale: adrianteal.com/product-page/ed

Experiments with a carousel suggest that some flies like to play:
"Seeking voluntary passive movement in flies is play-like behavior" biorxiv.org/content/10.1101/20

As a sanity check, we mined the Allen projection atlas, but again could not find any connection from ACA to HPC. Since our preprint came out, we tried fast blue retrograde tracing from HPC and worked through a cool single neuron PFC projectome database: mouse.braindatacenter.cn/

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Hahahahah. Holy shit.

So Zoom is irrevocably turning their entire network into a training data set: hackers.town/@devlogic/1108433

EVERY "public service" company is now attempting to extract value. They're all going for it. They're gonna burn it all down to try and turn AI into a financial exit. Search engines, communication backbones, social networks, everybody.

#Euclid’s Near-Infrared Spectrometer and Photometer instrument is dedicated to measuring the amount of light that #galaxies
emit at each wavelength.

The light from Euclid’s #telescope passes through the grism, which splits light from every star and galaxy by wavelength.

This information can be pulled out and analysed to determine the type of #galaxy and what its distance is.

#astronomy
esa.int/ESA_Multimedia/Images/

E assim começa a semana, num país que volta hoje a viver uma República Democrática do século XXI e não numa Monarquia Teocrática que branqueia e censura este tipo de crimes.

Cada ponto é uma das 4815 crianças abusadas sexualmente pela ICAR em Portugal. #JMJ

'I was a cub reporter, with limited insight, for the public broadcaster.Following HIV during a controversial time when the government refused to provide antiretroviral drugs to people infected with the virus, quickly taught me an important thing – a pandemic isn’t simply a disease gone viral. It’s a political, social, economic and human rights crisis, because the germ that causes the outbreak travels through a society ravaged by inequality.'

theguardian.com/global-develop

STING is a channel?

'On the basis of structural analysis, we hypothesized that human STING is a proton channel. Indeed, we found that STING activation induced a pH increase in the Golgi and that STING reconstituted in liposomes enabled transmembrane proton transport.'

science.org/doi/10.1126/scienc

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