A @pastelbio favourite #proteomics post from the last couple of months …
Pastel BioScience on Twitter https://twitter.com/PastelBio/status/1680658564749172736
Introducing PandaNovo for practical large-scale de novo peptide sequencing | https://www.biorxiv.org/content/10.1101/2023.07.15.549133v1 #proteomics
'Thiago was the ninth child aged under 14 to die in a shooting this year in Rio, according to the human rights NGO Rio de Paz. A tenth has died since. Most are hit by stray bullets, often during the police raids that routinely paralyse Rio’s low-income communities'
'Não foi por isto que a decisão de Carlos Moedas desagradou. Há mais e é pior. Manuel Clemente é um nome ligado ao encobrimento dos casos de abuso sexual por parte de padres da Igreja.'
Some very interesting facts about credit card debt and debt collectors, from Cory Doctorow. https://pluralistic.net/2023/08/12/do-not-pay/
1) When you default on credit card debt, it's sold to debt collectors -- who probably buy it for 5 cents on the dollar.
2) You are legally entitled to see the documentation of your debt before you pay it.
3) The collection agency doesn't have the documentation, it would be extremely difficult for the lender to find it because it could be in any of dozens of hard drives from the companies they've bought over the years, and they have no interest in doing so after they sell the debt.
4) Their profit model depends entirely on harassing people who don't know the law, and getting maybe 8% of the debts they paid 5% for.
5) If you know your legal rights, and demand written documentation as required by the law, they will write your debt off and write you off as someone it's not worth the bother of collecting from.
Blog 6. Image availability.
Where you can store your image data - for yourself, friends, and posterity.
#scicomm #BioImages #Microscopy #dataviz #images #Image #ScienceMastodon #Science
https://helenajamborwrites.netlify.app/posts/image_how_avail/
If you see this toot (yeah this one right here), can you boost it for me? It will help my new server federate with the wider Mastodon network. 🚀 🙏
Thanks to anyone who can do this. It is really appreciated! This server is small but will be hosting several #peace #SocialJustice and #Humanistic groups, so it is for a good cause.
In this episode we talked with Mary Gehring from MIT about her work on transgenerational inheritance and #epigenetic imprinting in plants. #podcast #chromatin #epigenetics
Listen here: https://www.activemotif.com/podcasts#mary-gehring
"History of water" is one of the best books I've ever read. A complex view of the world was there all along for Europeans, but control of narrative brought eurocentrism (devouring Europe with religious, national and racial identitism). #history #humanism #identity #XVICentury
https://www.edwardwilsonlee.com/historyofwater
P.S. A tradução portuguesa está muito cuidada.
https://expresso.pt/revista/culturas/livros/2022-11-20-As-viagens-de-Camoes-e-Damiao-de-Gois-um-livro-fascinante-de-Edward-Wilson-Lee-3e1b5dfe
'While moving upwards the intestinal villi enterocytes acquire different cellular fates, which is promoted by a gradient of Bmp ligands. In addition to this gradient individual Bmps have distinct activities in the differentiation of enterocytes.'
Berková et al @emboreports
"The suit failed. When called upon to issue a ruling in the Youngstown case, Judge Lambros turned on his own suggestion. There just was no precedent in US law to say that the workers or the people really had such a ‘community property right’. Lambros was torn between his moral sense that they should have one, and his professional duty as a judge to find that the law (then as now) recognised no such right. Youngstown Works shuttered for good."
https://aeon.co/essays/what-can-we-learn-from-john-rawlss-critique-of-capitalism
Many cancer waiting time targets set to be dropped in England
Missing your targets due to government underfunding?
Scrap the targets! No targets, no missed targets.
Happy to share some new results on the effects of cities and human activities on bird colouration.
Link: https://besjournals.onlinelibrary.wiley.com/doi/10.1111/1365-2656.13982
😀
'We used the minimal gene regulatory network of type 1 conventional dendritic cells (cDC1) to reprogram cancer cells into professional antigen-presenting cells (tumor-APCs). Enforced expression of the transcription factors PU.1, IRF8, and BATF3 (PIB) was sufficient to induce the cDC1 phenotype in 36 cell lines derived from human and mouse hematological and solid tumors.'
'Thiago was the ninth child aged under 14 to die in a shooting this year in Rio, according to the human rights NGO Rio de Paz. A tenth has died since. Most are hit by stray bullets, often during the police raids that routinely paralyse Rio’s low-income communities'
Episode 5 of the Cell Therapy Podcast is out, this time about NK cells cells: How do they function and can we utilize them as a cellular therapy?
In this episode we are joined by Dr Arnika Wagner & Dr Evren Alici both from the Karolinska Institutet and Dr Sigrid Skånland from Olso University Hospital for a chat about these exciting cells and how their anti-cancer effects are explored - and they can be used in the future.
Check it out: https://open.spotify.com/episode/5KPP7aUbRf75ewSijrUBsY?si=IIHr4vd7T428DyPII93Mng
'Não foi por isto que a decisão de Carlos Moedas desagradou. Há mais e é pior. Manuel Clemente é um nome ligado ao encobrimento dos casos de abuso sexual por parte de padres da Igreja.'
“Although news organizations are sometimes the targets of legal actions by government officials, including subpoenas seeking interview notes and other records, the search and seizure of the tools to produce journalism are rare.” https://www.nytimes.com/2023/08/13/business/media/kansas-marion-newspaper-police-raid.html #Kansas
'The Maui fires are another reminder that we have entered a fire age—a “pyrocene,” as the emeritus professor and wildfire expert Stephen J. Pyne has called it. Humans are still figuring out how to live in this new reality, playing catch-up as the world burns around us.'
https://www.theatlantic.com/science/archive/2023/08/maui-wildfire-hurricane-connection/674982/
"In a pathological culture, crucial information about potentially damning errors or hazards is hoarded by those in power and often used as a weapon to silence critics. In a bureaucratic culture, emphasis is on policies, rules, and compliance where similar information is either unwelcome or ignored. And a generative culture is one oriented on performance, where potentially damaging information is welcomed and distributed to the right people to act on."
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com