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This month's cover image accompanies the article Phylogenomic Analysis of 155 Helminth Species Reveals Widespread Absence of Oxygen Metabolic Capacity doi.org/10.1093/gbe/evad135 #science #evolution #biology #genome #evolgen_paper

"When leptin failed, he tried a different gut hormone, ghrelin, whose effects were the opposite of leptin’s. The more ghrelin an animal had, the more it would eat. Perhaps a drug that blocked ghrelin would make people lose weight.

“Again, it wasn’t that simple,” said Dr. Tschöp, who left Lilly in 2002."

nytimes.com/2023/08/17/health/

I discussed the origin of these new diabetes and weight loss drugs with Matthias, you can listen to "Obesity is a Brain Disease" scrolling down at the link below.

pioneercampus.org

'But income inequality within countries is rising, as measured by the Gini index, a measure of income distribution across a population. Globally, in the 15 years to 2019, economic output in terms of gross domestic product (GDP) roughly doubled, but the share of economic output earned by the workers producing the goods and services behind the increase fell from 54.1% in 2004 to 52.6% in 2019.'

nature.com/articles/d41586-023

'Consistently, these bans target materials written by and about people of color or LGBTQ+ individuals, and even though a 2022 poll found that 70% of parents oppose them, they are continuing at a rapid rate.

Now the Digital Public Library of America (DPLA) is trying to fight back. It recently launched the Banned Book Program, granting free nationwide access to books restricted in schools or libraries.'

theguardian.com/us-news/2023/a

"Even more concerning is the idea that content produced by generative AI is polluting the data sets on which future systems will be trained, threatening what some have called “model collapse”. By adding more imperfect information and deliberate disinformation to our knowledge base, generative AI systems are producing a further “enshittification” of the internet, to use Cory Doctorow’s evocative term. This means training sets will spew out more nonsense, rather than less."

ft.com/content/ed323f48-fe86-4

'Specific deletion of the nuclear isoform of RARα revealed an RARα isoform in the cytoplasm of T cells. Extranuclear RARα was rapidly phosphorylated upon TCR stimulation and recruited to the TCR signalosome.'

cell.com/immunity/fulltext/S10

'Alas, the results of most longevity studies are difficult to compare. This is in part because there are no clear, universally accepted standards for conducting such experiments or even for reporting such data.'

biorxiv.org/content/10.1101/20

'In different ways, political philosophers, economists and advertising executives have pointed out how our economic system capitalizes on the insecurities it produces, which it then prods and perpetuates, making us all insecure by design. Only by reckoning with how deep manufactured insecurity runs will it become possible to envision something different.'

nytimes.com/2023/08/18/opinion

This is great: you type your zip code into the app, and you're shown a complete list of books prohibited in your area; then download the e-reader, and these books are available to download.

theguardian.com/us-news/2023/a

I wonder if the book-banners will end up making these books more widely read than they ever were in libraries?

'Genome sequencing has also become a critical component in the development of one of the most promising alternatives to antibiotics: bacteriophage therapy.'

journals.plos.org/plosbiology/

'Our much loved Microbe Art Contest is coming back again this year to support International Microorganism Day on 17 September 2023! Help celebrate the wondrous world of microbes by getting creative and sharing your art! '

fems-microbiology.org/microbe-

'Here, we report the T1D Knowledge Portal (T1DKP), an open-access resource developed to help advance T1D research by democratizing access to genetic, genomic, and epigenomic data.'

journals.plos.org/plosbiology/

The interplay between lumen pressure and cell proliferation determines organoid morphology in a multicellular phase field model biorxiv.org/content/10.1101/20

In the end the best results were obtained using an ALFA tag labeled with primary and secondary antibodies, or a triple ALFA tag with an anti-ALFA PAINT nanobody. In both cases, we could visualize the actin mesh, rails and corrals in tagged presynapses! 20/23

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Assistant Professors of Neuroscience

Johns Hopkins University

Johns Hopkins University is currently accepting applications for six tenure-track Assistant Professor positions in neuroscience-related fields

See the full job description on jobRxiv: jobrxiv.org/job/johns-hopkins-

#ScienceJobs #hiring #research ...
jobrxiv.org/job/johns-hopkins-

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