Thiago Carvalho @cyrilpedia@social.cleverlibre.org

Finally made an #ImageJ macro to generate rotated zoom boxes!

'Gonsalves’s father recently died after a long descent into dementia. “We need better drugs for neurodegenerative diseases,” he told me. “But the way to do it is not to say, ‘Open the floodgates of the F.D.A.’ ”

https://www.newyorker.com/magazine/2023/06/26/relyvrio-als-fda-approval

RIP

"You can’t reach an audience on X," Dave Karpf wrote last week. "You can’t organize on X. You can’t follow breaking news on X. The people who made Twitter fun have all given up. There’s nothing worth sticking around for anymore."

https://defector.com/linda-yaccarino-is-the-last-funny-twitter-bit-left

'Yet, as microbiome experts Alan Walker of Aberdeen university and Lesley Hoyles of Nottingham Trent University pointed out recently, in the journal Nature Microbiology, all the excitement “has unfortunately also brought with it hype and entrenched certain misconceptions.” Their article knocks down 12 myths about the microbiome, ranging from exaggerations about its size and weight to misconceptions about the association between some microbial patterns and disease.'

https://www.ft.com/content/00619403-fd1a-483b-b67a-ac84112553b2

As Florida reports more new #COVID19 hospitalizations than any other state, #GOP sociopath #RonDeSantis demands more sickness and death as surely as if he wrapped his cold, creepy hands around the throats of his constituents and started squeezing. https://wapo.st/3LltbuZ

When facing the "All we need is STEM!" approach to education, my usual response is:

Developing the vaccine was the STEM problem; distribution & getting shots in arms was the Social Science problem; getting people to trust it & combatting misinformation was the Humanities problem -- which did we fail?

Brazil: Trials begin for pro-Bolsonaro rioters who ransacked government offices in January

> Four men are on trial in Brasília accused of crimes including armed criminal conspiracy, violent uprising against the rule of law and an attempted coup
https://www.euronews.com/2023/09/14/brazil-trials-begin-for-pro-bolsonaro-rioters-who-ransacked-government-offices-in-january #Brazil

Domain-based mRNA vaccines encoding spike protein N-terminal and receptor binding domains confer protection against SARS-CoV-2

Can current COVID-19 vaccines be improved upon?

https://www.science.org/doi/10.1126/scitranslmed.adf4100
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"In an ideal world, the pre-award process would be transparent, easily understood, and equitable. There would be equal access for all researchers to information about funding opportunities, along with tailored support to meet a range of needs, including those of underrepresented academics. There would be plenty of time and resources allocated for applications, and appropriate training for those in decision-making positions. You probably won’t be surprised to learn that, sadly, things look very different in the real world."

https://scholarlykitchen.sspnet.org/2023/09/12/inequities-in-grant-funding-start-early-how-can-we-address-them/

"In late 1977, as the Chilean military junta extended the state of siege in place since its 1973 coup and formally dissolved all political parties, Friedrich Hayek wrote a letter to a German newspaper, the Frankfurter Allgemeine Zeitung, to protest what he depicted as unfair international criticism of the government of General Augusto Pinochet."

https://jacobin.com/2023/09/neoliberalism-human-rights-democracy-dictatorship-chile-chicago-hayek-friedman-pinochet/

'The whole thing is a political show. They say they want to reduce the cost of the asylum system, but this boat and the way we have been dealt with must have cost a fortune. At the moment there are 39 asylum seekers here, and there are 20 staff for 39 people. Previously, in our hotel before we were moved to the Bibby Stockholm, there were only about 10 members of staff for 300 asylum seekers, so how can that be said to be about reducing the cost?

https://www.theguardian.com/commentisfree/2023/sep/12/suella-braverman-bibby-stockholm-terrified-asylum-seekers-ministers

'Têm uma intolerância visceral a qualquer restrição ao direito de propriedade e ao direito a fazer negócios – mesmo que estejamos a falar de cidadãos estrangeiros com condições socioeconómicas esmagadoras em comparação a quem vive dos rendimentos do seu trabalho em Portugal. O direito de propriedade e a liberdade económica não são como o direito à vida. Podem, e devem se for preciso, conhecer restrições.'

https://www.publico.pt/2023/09/13/opiniao/opiniao/mariana-mortagua-direito-fundamental-nao-residentes-fazerem-negocios-2063130

'Comprehensive studies of 14 complex structures of Mpro mutants with drugs or substrate revealed that mutations at the S1 and S4 subsites significantly decreased inhibitor binding, while mutations at the S2 and S4’ subsites unexpectedly increased protease activity.'

https://www.nature.com/articles/s41586-023-06609-0