Thiago Carvalho @cyrilpedia@social.cleverlibre.org

@lana I'm not sure, I think you'd have to check with the AMNH

'Além disso, a pretensa meritocracia do numerus clausus é uma tautologia: o sistema académico define o que é considerado “melhor” e depois declara que os aceites são os “melhores”. Mas onde está a demonstração que médias altas identificam os mais aptos para determinada profissão? Alguém acha que os melhores médicos se escolhem pela capacidade de receber e memorizar “aprendizagens” de Português ou Biologia no ensino secundário?'
@lmrocha

https://www.publico.pt/2023/11/27/opiniao/opiniao/jovens-reduzidos-numero-2071457

Androgen deprivation + anti-PD1 trial for #prostatecancer.

"These data provide a reasonable therapeutic rationale to combine ADT with immunotherapy, thus leveraging anti-tumor immunity while mitigating the ADT-mediated induction of suppressive mechanisms. To that end, we designed and initiated the PRIME-CUT Phase II trial (NCT03951831) treating men with metastatic castration-sensitive prostate cancer (mCSPC) with a combination of standard of care chemo-hormonal therapy and anti-PD-1 immunotherapy using the anti-PD-1 immunotherapy cemiplimab."
#immunology #immunotherapy

https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00362-8

"Here, using single-cell RNA sequencing, we demonstrate that a B cell transcriptional program poised for effector functions represents the major immune perturbation in blood samples from children with active INS. This transcriptional profile was associated with an extrafollicular B cell response marked by the expansion of atypical B cells, marginal zone-like B cells, and antibody-secreting cells"

https://www.nature.com/articles/s41467-023-43504-8

"Our study provides temporal transcriptional patterns and uncovers pan-tissue parallels between prostate and lung cancers, as well as connections to normal neuroendocrine cell states."

https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00365-3

"FEIRA DO PRATO FALANTE 5 & 6 de Dezembro com visitas das 12h às 20h." @almeida_felipa featuring @hunchbacksociety & more.

"Even then it wasn’t until well after de Gaulle’s death in 1970 that the story of the French Jews began to be told fully, not least the fact that the Vichy regime had introduced antisemitic measures without German pressure and that Jews had been rounded up by French policemen serving French officials"

https://www.nybooks.com/articles/2023/12/07/the-collaborator-in-chief-the-trial-of-marshal-petain/

"Under an immigration law passed in 1996, asylum seekers must wait 180 days before even applying for a work permit. In practice, the law has forced immigrants to scrounge for off-the-books jobs as food delivery workers or restaurant dishwashers or else live off meager government and charitable assistance."

https://www.nytimes.com/2023/11/26/nyregion/migrant-crisis-holocaust-refugee.html

"Herzog, for whom nature is an obscenity, a squalid turmoil in which life-forms flourish briefly in order to kill or be killed before, as he puts it, ‘just rotting away’, reserves an especial distaste for the ‘sheer hell’ of underwater existence."

https://www.lrb.co.uk/the-paper/v45/n23/david-trotter/go-for-it-losers

"Only 100 cases of natural chimerism are documented, but there may be many more. Scientists estimate that 36 per cent of twin pregnancies involve a vanishing twin. Most such twins likely disappear without a trace, but some get partly absorbed into their neighbour."

https://aeon.co/essays/being-a-twin-helpfully-cracks-open-our-ideas-of-individuality