Thiago Carvalho @cyrilpedia@social.cleverlibre.org

December 7, 1872, HMS Challenger sets sail from Portsmouth, England. The Challenger expedition was at the time the most ambitious scientific mission to study life forms and sediments of the deep ocean ⛵
https://paleonerdish.wordpress.com/2013/07/01/the-challenger-expedition-and-the-beginning-of-oceanography/

Some #parasite infected sticklebacks fight back with internal scaring to prevent the parasite from taking hold and the scaring also makes the #fish stiffer, helping them to beat a hastier retreat from predators

#zoology #biology #comparativephysiology

https://journals.biologists.com/jeb/article/226/23/jeb247041/336507

Read the full research at https://journals.biologists.com/jeb/article/226/23/jeb246684/336506

Issue 22 is complete!

On the cover: a Drosophila testis stained using single molecule fluorescence in situ hybridization with probes against cycB RNA (green) and loopin-1 RNA (red), with DAPI (blue) marking DNA. See Baker et al.
https://journals.biologists.com/dev/article/150/22/dev201709/335491/Cell-type-specific-interacting-proteins

Also in Issue 22:
▪4 Research Highlights on FSH, cell networks, hair follicles & syncytia
▪In preprints on RNA in PRC2
▪People behind the papers interview
▪2 Transition in development interviews
▪XCI meeting review
https://journals.biologists.com/dev/issue/150/22

A new method to identify enhancers:

MAE-seq refines regulatory elements across the genome
Nucleic Acids Research, gkad1129, https://doi.org/10.1093/nar/gkad1129

Notably, quoting the authors:
"33.85% of the identified enhancers were identified as de novo ones with no epigenetic modification"

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#preprints #openscience

“Most great ideas, or a lot of them anyway, were thought at the time to be rubbish, and you were reckoned an idiot for having them.
This was true of stupid ideas too.
Telling them apart was the tricky bit.”
Mick Herron – Slough House
#SlowHorses #SloughHouse

"Here, we combine a stationary-phase screening method with deep learning-powered virtual screens and toxicity filtering to discover compounds with lethality against metabolically dormant bacteria and favorable toxicity profiles."

https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(23)00387-2

"These crises are not about the planet going haywire. They are crises caused by failures to assign and enforce social responsibilities. And the wealthiest, most powerful and most capable societies that have ever existed on this planet are behaving as if they owe nothing for what they have gained at the expense of imperiling life on Earth."

https://www.nytimes.com/2023/12/04/opinion/rich-nations-climate-change-summit.html

'Who among us can honestly say we are capable of parsing a WhatsApp message from Dominic Cummings dated 23 August 2020 that reads: “I also must stress I think leaving Hancock in post is a big mistake – he is a proven liar who nobody believes or shd believe on anything, and we face going into autumn crisis with the cunt in charge of NHS still.”

https://www.theguardian.com/commentisfree/2023/dec/05/boris-johnson-covid-inquiry-prime-minister

"In particular, our results show that AlphaFold predictions are not better representations of the contents of a crystal than the models deposited in the PDB, as the deposited models agree much more closely with experimental data where the predicted and deposited models differ."

https://www.nature.com/articles/s41592-023-02087-4#Sec7

'The chaos at the heart of Britain’s handling of Covid-19 has been laid bare in recent weeks, with testimonies describing a “toxic” culture in Downing Street and how Johnson was “bamboozled” by scientific data.'

https://www.ft.com/content/bea342f8-9289-41cb-83ae-1e97c47e33fa

Human O-linked Glycosylation Site Prediction Using Pretrained Protein Language Model https://www.researchsquare.com/article/rs-3587524/v1

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#proteomics #prot-preprint

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#ASAPbio #ECRs #ECR #preprints #research #science #publishing #OpenScience

A receptor protein called TGN46 has an important role in sorting secretory proteins into vesicles going to different destinations inside cells. #Golgi https://elifesciences.org/articles/93490?utm_source=mastodon&utm_medium=social&utm_campaign=organic_insights

Je rappelle le silence assourdissant en France quand le poste de conseillère scientifique à la commission européenne a été supprimé sous la pression d'ONG anti-OGM.
https://toutsepassecommesi.wordpress.com/2014/08/11/des-ong-dont-greenpeace-ne-semblent-pas-vouloir-dune-politique-europeenne-scientifiquement-fondee-sur-les-ogm/
https://toutsepassecommesi.wordpress.com/2014/11/13/que-reproche-t-on-a-la-conseillere-scientifique-a-la-commission-europeenne/
(Désolé pour les liens cassés, le cafe-sciences.org ayant supprimé mon blog il n'y a que cette copie de sauvegarde.)