Thiago Carvalho @cyrilpedia@social.cleverlibre.org

"Despite recent advances in generative models for proteins, we argue that there are three properties that have yet to be realized simultaneously in one system. These are: modelling the joint, all-atom likelihood of sequences and three-dimensional structures of full protein complexes; achieving this with computation that scales sub-quadratically with the size of the protein system; and enabling conditional sampling under diverse design constraints without retraining."

https://www.nature.com/articles/s41586-023-06728-8

@gpollara @Kaetchi I can tell you from the side of manuscript services & editing, the drop in demand for basic editorial services (the ones that involve correcting language issues and general paper structure) in 2023 has been absolutely brutal. For some of my colleagues, it's been 2/3 of their work just evaporated.

"One of the strangest and least-studied enigmas, though, is how tattoos survive at all. Our immune system is constantly doing its darndest to destroy them—and understanding why it fails could clue us in to one of our bodies’ most important functions, even when we leave the skin blank."

https://www.theatlantic.com/science/archive/2023/03/tattoo-science-immune-system-effects/673462/

"In normal times, the United States stands out among advanced democracies for its high levels of poverty and its low levels of aid. In 2019, right before Covid struck, America’s relative child poverty rate resembled that of Mexico or Bulgaria."

https://www.nybooks.com/articles/2024/01/18/tools-to-end-the-poverty-pandemic-the-viral-underclass/

@Kaetchi @gpollara I do think that this is the one area where the advances in AI will help. The translation apps are getting very good - you still have to proofread and edit very carefully, but the current (not future) state of these tools is remarkable.

“Desde 2008 que os rendimentos na UE cresceram mais entre a população com 60 anos ou mais. As discrepâncias entre os mais velhos e os jovens são mais pronunciadas no Sul da Europa, onde os rendimentos do grupo etário mais velho aumentaram, enquanto os dos mais jovens diminuíram”

https://www.publico.pt/2023/12/29/sociedade/noticia/menos-rendimentos-capacidade-comprar-casa-jovens-sul-europa-pior-geracoes-velhas-2075156

It's crystal ball season:

"Will Novo Nordisk end the year as Europe’s most valuable company?

Yes. In 2023, obesity treatment Wegovy became one of the most successful drug launches of all time and Denmark’s Novo overtook luxury goods group LVMH in value. But 2024 looks challenging for those selling highly priced handbags to China — while Novo’s main issue in selling highly priced obesity medication is how quickly it can produce it. After winning over patients and doctors to using its diabetes drug for obesity, Novo is now expanding access and coverage in a market where perhaps 1mn people are being treated out of a patient population of 100mn in the US and 700mn globally."
- Helen Thomas

https://www.ft.com/content/7eef99e6-6bd5-4e84-85c1-ec77cc0671af

"Transcriptomic and chromatin accessibility analyses identified a reactive microglial population defined by the concomitant expression of inflammatory signals and cell-intrinsic stress markers whose frequency increased with age and APOE4 burden."

https://www.cell.com/immunity/fulltext/S1074-7613(23)00532-0