Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
My department is hiring an Assistant Professor of Social Data Science! I would love for this job to go to someone knowledgeable about open science, reproducibility, and meta-science. Our department is fun, supportive, and has extensive expertise in structural equation modeling, Bayesian stats, regularization, text mining, meta-science, and research synthesis. The campus has a small forest, and the city can be easily reached from Utrecht, Rotterdam, even Amsterdam. https://tiu.nu/21154
Molecular Systems Biology/EMBO Molecular Medicine now hiring a Scientific Editor, the job is in Heidelberg
Thiago Carvalho
boosted
#joboffer We have open #PhD and #Postdoc positions funded by the Swiss National Science Foundation #SNSF – one week left to apply- work with us on Drosophila neuroscience and sexual behavior in beautiful Fribourg!
https://www.unifr.ch/med/fr/section/jobs/
Thiago Carvalho
boosted
RT @StanBrouns
We just posted a preprint proposing a new role for the 50-year old conundrum of phage-encoded tRNAs: insensitivity to host tRNA depletion by anticodon nucleases (e.g. VapC). Great data analysis and hypothesis building by @DaanFvdBerg
Thiago Carvalho
boosted
Head of the Department of Biology @koebenhavns_uni in the beautiful capital of Denmark 🇩🇰 is advertised.
My personal preference: Candidates with a background in Genomics. Who would have guessed at @genomics.social. 🧬 Please re-toot!
https://www.nature.com/naturecareers/job/head-of-department-university-of-copenhagen-765659
Thiago Carvalho
boosted
RT @HVodermaier
Interested in working as a scientific editor for @embojournal?
We are looking... especially if you have expertise related to #RNA, #chromatin & #transcription!
and no, it is not as bad as depicted below - most things are electronic by now 😉
Thiago Carvalho
boosted
Lane Lab journal club this morning - We will be discussing one of several papers dismissing the prospect that astrocyte can be converted to neurons in situ via PTBP1ablation.
https://www.jneurosci.org/content/42/38/7309
"Our analyses of the expression, chromatin accessibility, and methylation of chrX genes suggest that XIST+ male cancers display partial signatures of X chromosome silencing and also indicate an association between XIST activation and chrX copy number. "
https://www.sciencedirect.com/science/article/pii/S2405471222004033?dgcid=author
Thiago Carvalho
boosted
First in human trial of CRISPR edited neoantigen specific tumour infiltrating lymphocytes. NeoTCR-transgenic T cells were detected in tumour biopsies and toxicity mainly from lymphodepletion and CRS. Showed feasibility of using a neoantigen specific gene editing approach to TIL therapy
https://www.nature.com/articles/s41586-022-05531-1
'Young life science researchers are leaving academia at unprecedented levels for lucrative jobs in the private sector. Like Gorashi, many of them are entering graduate programs already knowing they don’t want to remain in academia long-term, making their time in the ivory tower a pit stop rather than a final destination.'
On vaccine development as a way out of the antibiotic resistance crisis:
"Of the six bacteria that are responsible for the most deaths linked to drug-resistance — a combined 929,000 fatalities per year — there is a licensed vaccine for just one: Streptococcus pneumoniae, which can cause pneumonia and other illnesses."
#Antibiotics #AntibioticResistance #Microbiology #Immunology #vaccine
https://www.ft.com/content/1bbbdaf5-ea2a-44f4-8640-e24b32d5cfb1
Forensic work showing how the Covid19 vaccine patent waiver proposal was killed.
"Big Pharma used its vast lobbying and influencing efforts to try to kill a proposal that threatened the very tenets of the industry. Top industry executives enjoyed direct access to senior officials within the EU, which was opposed to the proposal from the very start and encouraged potentially rogue member countries, including Italy and France, to fall into line. And the U.S., after a dramatic late intervention in favor of a waiver for vaccines, eight months after the proposal had been tabled, failed to follow through as the Biden administration came under pressure from industry and Congress, as reported by the Intercept."
Thiago Carvalho
boosted
Evidence for sustained evolution of SARS-CoV-2 in white-tailed deer and of deer-to-human transmission. Damn.
Divergent SARS-CoV-2 variant emerges in white-tailed deer with deer-to-human transmission | Nature Microbiology
Serious heart damage is the most severe side effect of doxorubicin in cancer chemo, but the cause is not clear.
New work from Abe et al shows that
"DOX accumulated in mitochondria by intercalating into mitochondrial DNA (mtDNA), inducing ferroptosis in an mtDNA content-dependent manner. In addition, DOX disrupted heme synthesis by decreasing the abundance of 5'-aminolevulinate synthase 1 (Alas1), the rate-limiting enzyme in this process, thereby impairing iron utilization, resulting in iron overload and ferroptosis in mitochondria in cultured cardiomyocytes."
Thiago Carvalho
boosted
WHO has upgraded its risk assessment of Uganda's #Ebola outbreak from high to very high on the national level and from low to high for the region.
The perception of increased risk comes from having cases in Kampala and the mobility of some of the cases & contacts.
To date there have been 157 confirmed + probable cases & 74 confirmed + probable deaths. https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON423
Thiago Carvalho
boosted
#bioinformatics #introduction Hello Tooters! I’m George, I head up bioinformatics at the MRC LMS. Reformed immunologist, retro/virologist, repetitive elements, genomes, *seq, #nextflow. Let’s see what Mastodon can do for us all!
Thiago Carvalho
boosted
The outbreak.info toolset that Dr. Kristian Andersen and collaborators put together to track the SARS-CoV-2 variants has been fixed and all the recent variants now display, so we can see how they diverge: https://outbreak.info/compare-lineages?pango=BA.1&pango=BA.2&pango=BA.2.12.1&pango=BA.2.75&pango=BA.2.75.2&pango=BA.4&pango=BA.4.6&pango=BA.5&pango=BA.5.2.6&pango=BF.7&pango=BQ.1&pango=BQ.1.1&gene=S&gene=ORF1a&gene=ORF1b&gene=ORF3a&gene=E&gene=M&gene=ORF6&gene=ORF7a&gene=ORF7b&gene=ORF8&gene=N&gene=ORF10&threshold=75&nthresh=1&sub=false&dark=false
Thiago Carvalho
boosted
Here's a lil thread of things I *wish* somebody had told me when I started advising #STEM #gradstudents as a lab head, #PhD program director, and grad school conflict-resolution officer. Or maybe they did and I wasn’t listening? 🧵
#gradschool #inclusion #macademia #AcademicMastodon #ScienceMastodon #academia #academics
Thiago Carvalho
boosted
Very cool preprint from Bin Wu's lab.
They found bursting behavior of #translation by #SingleMolecule #mRNA #imaging in live cells, which is modulated by 5'UTR.
@biorxivpreprint
Thiago Carvalho
boosted
This is why I left Twitter and why I don't think Twitter is a safe environment, *especially* for the most vulnerable:
"Everyone here should also know that our CISO, Chief Privacy Officer and Chief Compliance Officer ALL resigned last night. This news will be buried in the return-to-office drama. I believe that is intentional... I do not believe he [Elon] cares about the human rights activists. the dissidents, our users in un-monetizable regions..."
https://www.theverge.com/2022/11/10/23451198/twitter-ftc-elon-musk-lawyer-changes-fine-warning
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
