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Folks interested in #CancerDrugDevelopment should check this months edition of #MolecularOncology 👇

febs.onlinelibrary.wiley.com/t

A thematic issue with excellent reviews on #DrugResistance #DrugDevelopment and #DrugDesign

We also contributed a review on targeting dNTP #metabolism in cancer, which we discuss in the context of (selectively) inducing DNA lesions in cancer cells and in the refinement of current antimetabolite based therapies

#NucleotideMetabolism #DNARepair #DNADamageResponse #SAMHD1

@ondinecleaver2022 @DenisDuboule @opourquie @RogersLabUCD @HaoYin @scottbarolo @kkroll @SpagnoliLab @Mill_lab @jamesbriscoe @MokalledLab @AaronJohnson @ebardot Ondine, we could pull the followers and followed by the Twitter SDB account and have it as a CSV file people can use to merge their follows. What do you think?

#introduction time!
I am a #social systems biologist.
I study how #evolution created #sociallife.
I study #ants and ant colonies as a model for #development.
I study the evolution and impact of socially transferred materials (e.g. milk, eggs, seminal fluid).
I lead the Lab of Social Fluids at University of Fribourg.
I am also the founder of The Catalyst, a science entertainment collective.
I am passionate about #scicomm, #genderequality, and making #academia a better place.

#introduction Hi fellow mastodonians!

I'm a neuroimmunologist with a focus on #Tcells in #multiplesclerosis. My lab uses #Tcr-seq , #antigen discovery, and in vitro and in vivo models to study the functions of T cells in MS with the goal of developing novel #biomarkers and targeted #therapeutics.

Here for communicating basic and translational science with like-minded folks. Looking forward to connecting!

"Here, I review what has been learned about the evolution and genetics of life-history variation in D. melanogaster by drawing on numerous sources spanning population and quantitative genetics, genomics, experimental evolution, evolutionary ecology, and physiology."

Thomas Flatt, in Genetics (fm 2020)

academic.oup.com/genetics/arti

@giorgiogilestro this is exactly why #ReviewCommons exists! Submit to ReviewCommons and forward to either Mol Sys Biol or PLOS Comp Biol with reviews in hand.

Get a sense without committing to a journal at time of submission.

Free online course on with

François Fleuret  
Reminder that my deep learning course at the University of Geneva is entirely available on-line. 1000+ slides, ~20h of screen-casts. Full of exampl...

This one is for everyone nostalgic for old school metabolic maps

"We studied the genetic architecture of the human plasma metabolome using 913 metabolites assayed in 19,994 individuals and identified 2,599 variant–metabolite associations (P < 1.25 × 10−11) within 330 genomic regions, with rare variants (minor allele frequency ≤ 1%) explaining 9.4% of associations."

nature.com/articles/s41591-022

'Charles Darwin wandered out over a coral reef. He gazed through the water into the ‘gullies and hollows’ below. He admired the scene, though not excessively. The naturalists he had read had described ‘submarine grottos decked with a thousand beauties’. This was, he thought, ‘rather exuberant language’. The marine biologist Juli Berwald was more impressed. She describes her first encounter with a coral reef as ‘love at first sight’. The reef was ‘awash in colour ... beyond Baroque ... each delicate petal and tendril was a revelation; each filigree and lattice an astonishment.’ She had one thing Darwin didn’t: a snorkel.'

lrb.co.uk/the-paper/v44/n22/li

#introduction

Hi everyone! I'm a faculty member in the Department of #Microbiology at the #UniversityofPennsylvania.

My lab loves to study #host:pathogen interactions & #Innateimmunity from the molecular to organismal level.

I also care a lot about #education, #mentoring, & #diversity, #equity, & #inclusion in #STEM. I am Chair of our Microbiology, Virology, & Parasitology Graduate Program & Vice-Chair of Diversity & Inclusion for #PennMicro. I look forward to learning from others here!

I am an at the . I study how our immune system can influence our health, especially brain health. I love constructive discussions about science and how to make a better place for everyone. I love , , , and learning from my 2 sons. Oh and my 3 @Cats too.

"From their hero Paul Cézanne, they’d learned to break down and reassemble multiple perspectives. Scrutinizing central African sculpture in Paris’s colonial ethnology museum, they’d learned to clarify bodies into pure geometry. Crossing those two wires they jolt the history of western art, and spark a whole new kind of image that, for the first time in 500 years, is done with simulating real life. "

nytimes.com/2022/11/11/arts/de

"Here, we reviewed a T Cell Receptor (TCR)-primed environmental cue-boosted model of adipose Treg cells’ tissue adaptation, especially in response to IL-33, IFN-α, insulin and androgen signals, which trigger sophisticated transcriptional cascades and ultimately establish unique transcriptional modules in adipose Treg cell subsets."

onlinelibrary.wiley.com/doi/ab

Mastodon FAQ: Toot sweet?

mjcarty.com/mastodon-faq-toot-

My latest blog post is an attempt to answer some frequently asked questions for new Mastodon users or the Mastodon-curious.

Along the way, it takes in some wise words from the following excellent folk: @davidallengreen; @clive; @teago_emplaw; and @Kategl.

Also featuring some art from the wonderful Winsor McCay, who (I was delighted to discover) was very fond of drawing the mastodon!

#Blogulence #MastodonFAQ

mjcarty.com/mastodon-faq-toot-

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