Thiago Carvalho @cyrilpedia@social.cleverlibre.org

Bringing V(D)J analysis to the single-cell space is difficult. We continued to developed dandelion to help with this, finding some interesting new biology along the way in this new pre-print! @Cambridge_Uni@twitter.com @sangerinstitute@twitter.com @ClatworthyLab@twitter.com @teichlab@twitter.com https://www.biorxiv.org/content/10.1101/2022.11.18.517068v1

#introduction My name is Yana Safonova, I am an assistant professor at Johns Hopkins University.
My lab develops computational methods for analyzing adaptive immune responses and repertoires.
Research interests include (but not limited to) immunogenomics, antibody responses to COVID-19, HIV, and flu, comparative immunology, and co-evolution of pathogens and vertebrate immunity.

Register now for the EMBO-EMBL symposium on the AGEING OF THE GENOME #EESAgeing https://www.embl.org/about/info/course-and-conference-office/events/ees23-04/

I am interested in using #NMR to understand biology, so my work varies from #biophysics #kinetics #dynamics #proteinfolding to #structuralbiology

An example of our collaborations, with @ak947 and @lapassmore where we showed that Fip1 dynamics are required for CPF activation. NMR was used to study the conformational dynamics of Fip1 within the 850-kDa CPF complex.

http://www.genesdev.org/cgi/doi/10.1101/gad.348671.121

#NMRchat #protein #IDP #biochemistry #mRNA #3'endprocessing

Interesting review: 'Lipid A heterogeneity and its role in the host interactions with pathogenic and commensal bacteria'

https://academic.oup.com/microlife/article/doi/10.1093/femsml/uqac011/6605279

Published a few months ago, but missed it then.

#Conference — only two weeks to go until our #MicrobiologySociety Focus Meeting about #MicrobialEvolution in #Manchester UK 22-23 November

#ExperimentalEvolution #PathogenGenomics #Microbiome #dynamics #Mathematical #modelling #crispr #plasmids #phages #GeneRegulatoryNetworks #PredictingEvolution #EvolutionaryApplications #MutationRates #HorizontalGeneTransfer #EvolutionaryTheory #EvolutionaryInnovation #EvolutionaryRescue #EcoEvolutionaryDynamics

To register: https://microbiologysociety.org/event/full-events-listing/understanding-and-predicting-microbial-evolutionary-dynamics.html#tab-4

As I recently joined, I would like to introduce myself. I am an Assistant Professor at Leiden University, where my group works on covalent inhibitors and chemoproteomic technologies to discover new targets for antibiotics. Next to sharing our science, I am striving to share thoughts on the scientific literature that I read with a focus on #ChemicalBiology, #Chemoproteomics and #Antibiotics. It would be great, if you follow me, if you are interested in these topics. https://www.universiteitleiden.nl/en/staffmembers/stephan-hacker#tab-1

#introduction

Hi all, I'm a PhD candidate at Yale University.

I am interested in host-parasite #coevolution in #microbial communities, especially #bacteria and #phage. I'm also interested in building high-throughput methods, both in the lab and in #rstats.

I use a combination of #ExperimentalEvolution and #MathematicalModeling throughout my work

Today is #TransDayofRemembrance when we honor and remember trans lives taken by violence. How horrifying that a deadly attack upon the LGBTQ+ community in Colorado Springs should occur right before this solemn day.
Hate isn’t born in us. It is taught. It must end.
This starts with our political leaders, who must cease their cynical attacks against our community before another attack occurs.
Call out the hate. Remind them of its consequences. Hold them to account.

Great session hearing about the development of Cancer #Immunotherapy in Canada this morning at BioCanRx #Summit4CI

Rob Holt gave a very stimulating overview of their work on direct administration of CAR-Lentivirus for in vivo #CART. The take-home is that in vivo LV will be difficult to translate clinically, but maybe not impossible. He finished the talk to say that #mRNA LNP might still be the best approach for in situ CAR.

Looking forward to more talks!

https://www.cell.com/molecular-therapy-family/methods/fulltext/S2329-0501(22)00071-7

Here’s my (required?) #introduction - I’m Tim, a #scientist living in #Austria working at the @istaustria near Vienna. I work on #neural_network_dynamics #plasticity #neurotheory. PhD w Larry Abbott at #brandeis and #columbia, postdoc w Wulfram Gerstner at #EPFL, 1st lab at #Oxford for 7 years before moving in 2020. Married to Ms Moon, w/ 3 daughters (a cat). I’ve been 20 years German, 1.5 Greek, 10 American, 4 Suisse, 7 British & 2 Austrian, sorta in that order. I #row #Am_I_doing_it_right?

Hi folks! Here is my #introductionpost. I am a #neuroscientist & #psychiatrist based in NYC. I started a lab at Columbia in 2021 focused on how #stress disrupts the #brain #circuits that govern social, cognitive & reward seeking #behavior. We use #electrophysiology & #optogenetics in freely moving mice to study how dynamic #neural activity, eg, #oscillations yield insight into #susceptibility #resilience #anhedonia & new treatments. I also post about #cooking. #twitterMigration #NeuroMastodons

A missed cancer diagnosis. — and an Irish hero. https://www.nytimes.com/2022/11/16/world/europe/vicky-phelan-cancer-ireland.html

A little introduction to what I do: My lab has demonstrated effects on autophagy, as well as other membrane-induction pathways, by poliovirus, rhinoviruses, and EV-D68. We have also published on the role of amphisome vesicles in promoting picornavirus particle maturation, the COPII and autophagic origins of viral RNA replication organelles. More recently we published on the roles of SNAP/SNARE proteins in virus maturation and release. #LoveVirology