@gaymanifold Sorry if there was a misunderstanding, but as the inverted commas indicate, this is a quote from the preprint in the link -it's not my work. That said, my two cents are that with an open source code we have a better change of gaining fundamental understanding beyond structural predictions. It's also important to note that for basic biochemistry, cell biology & physiology, these structures are also of great value, not just for engineering.

**Thiago Carvalho** · Nov 23, 2022, 10:22

Thiago Carvalho boosted

**Behaviour 2023** @behaviour2023@ecoevo.social · Nov 23, 2022, 10:22

Nov 23, 2022, 10:22

Behaviour 2023 @behaviour2023@ecoevo.social

Save the date! We are delighted and honoured to host the next #Behaviour2023 conference, 14-20 August 2023!

Learn more about the conference in www.behaviour2023.com

See you all in Bielefeld!

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**Thiago Carvalho** · Nov 23, 2022, 12:53

Thiago Carvalho boosted

**J. Evol. Biol** @JEB@ecoevo.social · Nov 23, 2022, 12:53

Nov 23, 2022, 12:53

J. Evol. Biol @JEB@ecoevo.social

This Months #editorschoice

Guppies are a classic example of #parallelevolution but are they really so parallel? An analysis of published #guppy papers by @alexisheckley @AllegraPearce4 @photopidge @ecoevoevoeco @KristaOke
shows low extent of parallelism

http://ow.ly/s8S450LLUG9
#evolution #guppy #guppies #societyjournal

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**Thiago Carvalho** · Nov 23, 2022, 03:57

Thiago Carvalho boosted

**Axel Visel** @AxelVisel@genomic.social · Nov 23, 2022, 03:57

Nov 23, 2022, 03:57

Axel Visel @AxelVisel@genomic.social

Genome Research @genomeresearch is now also here!

https://genomic.social/@genomeresearch

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**Thiago Carvalho** · Nov 23, 2022, 12:32

Thiago Carvalho boosted

**Fyodor Urnov** @urnov@genomic.social · Nov 23, 2022, 12:32

Nov 23, 2022, 12:32

Fyodor Urnov @urnov@genomic.social

The most recent approved gene therapy, as @STAT reports, will cost $3.5m per patient.
Editas just abandoned a gene editing program because it has <300 patients in the US.
= the challenge of affordability and health justice for CRISPR cures has never been this urgent.
https://www.statnews.com/2022/11/22/fda-approves-a-gene-therapy-for-the-inherited-bleeding-disorder-hemophilia-b/

**Thiago Carvalho** · Nov 13, 2022, 13:17

Thiago Carvalho boosted

**Andrew Conway Morris** @Mozza@critcare.social · Nov 13, 2022, 13:17

Nov 13, 2022, 13:17

Andrew Conway Morris @Mozza@critcare.social

My #introduction

I’m a clinician scientist and ICU consultant based in Cambridge, UK. I study the immune effects of critical illness, particularly why neutrophils fail and how this leads to nosocomial infections. Through this I’ve collided with a number of research areas, including diagnostics for pneumonia, transcriptional responses to pathogens and air scrubbing- collecting eclectic interests along the way.
Active in ESICM, currently chairing the INF section.

**Thiago Carvalho** · Nov 23, 2022, 10:58

Thiago Carvalho boosted

**Sally Lowell** @cellysally@mas.to · Nov 23, 2022, 10:58

Nov 23, 2022, 10:58

Sally Lowell @cellysally@mas.to

"The mere existence of such a cell should be one of the great astonishments of the earth."

"People ought to be walking around all day, all through their waking hours calling to each other in endless wonderment, talking of nothing except that cell.”

by Lewis Thomas, from "The Medusa and the Snail"

Watch a Salamander emerge From a Single Cell https://www.youtube.com/watch?v=SEejivHRIbE

#DevBio

**Thiago Carvalho** · Nov 22, 2022, 18:42

Thiago Carvalho boosted

**Mayuri Sadoine 🇪🇺🇺🇦** @MayuriSadoine@mstdn.social · Nov 22, 2022, 18:42

Nov 22, 2022, 18:42

Mayuri Sadoine 🇪🇺🇺🇦 @MayuriSadoine@mstdn.social

#Introduction I am Scientist #HHU, social Media Liaison @APSbacteriology & AAAS Women in STEM community Ambassador. I love sensors, microbes, plant-pathogens among others. Concerns about inclusion & diversity in STEM and climate emergency #Biophysics#Biosensors # #plantpathology #microbes #WomenInSTEM #ClimateAction. I am now also on Mastodonte. My twitter: https://twitter.com/MayuriSadoine & My linkedin: https://www.linkedin.com/in/mayuri-sadoine-7082694b

**Thiago Carvalho** @cyrilpedia@social.cleverlibre.org · Nov 23, 2022, 12:11

**Thiago Carvalho** @cyrilpedia@social.cleverlibre.org · Nov 23, 2022, 12:11

Nov 23, 2022, 12:11

Thiago Carvalho @cyrilpedia@social.cleverlibre.org

'We have developed OpenFold, a complete open-source reimplementation of AlphaFold2 that includes training code and data. By training OpenFold from scratch and matching the accuracy of AlphaFold2, we have demonstrated the reproducibility of the AlphaFold2 model for protein structure prediction. Furthermore, the OpenFold implementation introduces technical advances over AlphaFold2, including markedly faster prediction speed.'

https://www.biorxiv.org/content/10.1101/2022.11.20.517210v1?med=mas

**Thiago Carvalho** · Nov 22, 2022, 12:51

Thiago Carvalho boosted

**Paul Wicks, PhD.** @paulwicks@med-mastodon.com · Nov 22, 2022, 12:51

Nov 22, 2022, 12:51

Paul Wicks, PhD. @paulwicks@med-mastodon.com

*PRO NERD TIP*

Today I learned about "The Wikipedia Library Card". If you've been a WP editor for >6 months, have made >500 edits, at least 10 edits in the last month, and are not blocked for being a cretin, you can access a *ton* of paywalled content for free.

ScienceDirect, AAAS, The BMJ, both APAs, EBSCO, Springer, Nature, Wiley, and many more.

https://wikipedialibrary.wmflabs.org/about/

All those hours in 2005 spent editing sci-fi book articles finally paying off!

**Thiago Carvalho** · Nov 23, 2022, 12:06

Thiago Carvalho boosted

**Fabrizio Chiodo** @FabrizioChiodo@mastodon.uno · Nov 23, 2022, 12:06

Nov 23, 2022, 12:06

Fabrizio Chiodo @FabrizioChiodo@mastodon.uno

"The advent of the gene-editing technology CRISPR–Cas9 in the 2010s provided a catalyst for the field, making it easier to modify not only the gene involved in α-Gal production, but a host of others that might help human bodies to tolerate pig organs."

#glycotime

RT @Nature@twitter.com

Will pigs solve the organ crisis? The future of animal-to-human transplants https://go.nature.com/3EWxMRu

🐦🔗: https://twitter.com/Nature/status/1595376796740251648

**Thiago Carvalho** @cyrilpedia@social.cleverlibre.org · Nov 23, 2022, 12:04

**Thiago Carvalho** @cyrilpedia@social.cleverlibre.org · Nov 23, 2022, 12:04

Nov 23, 2022, 12:04

Thiago Carvalho @cyrilpedia@social.cleverlibre.org

Richard Lenski (at his blog) on S.J Gould & the #LTEE

"Of course, Gould’s experiment is impossible at a paleo-planetary scale. But at a more modest scale, one of the main goals of the LTEE is to study the repeatability of evolution. And so, I often quote from Wonderful Life when I’m giving talks about the experiment. Thus, it’s only natural that someone might wonder if Gould’s book had inspired me to start the LTEE."
#Evolution

https://telliamedrevisited.wordpress.com/2022/11/22/its-a-wonderful-life/

**Thiago Carvalho** · Nov 23, 2022, 12:02

Thiago Carvalho boosted

**Ines Carvalho** @InesCCarv@ecoevo.social · Nov 23, 2022, 12:02

Nov 23, 2022, 12:02

Ines Carvalho @InesCCarv@ecoevo.social

#introduction
I’m a conservation biologist focusing on #cetaceans. I'm presently using molecular, ecological, and demographic approaches to understand the interconnectedness of bottlenose dolphins in the Iberian Peninsula region; with a particular interest in the declining resident population of Sado estuary, 🇵🇹 !!

Before, I studied cetaceans (mostly humpback whales) in 🇸🇹 (west Africa).

Other interests around here: #popgen,#POPs, #marineconservation; #MPAs; #SciComm

**Thiago Carvalho** @cyrilpedia@social.cleverlibre.org · Nov 23, 2022, 11:58

**Thiago Carvalho** @cyrilpedia@social.cleverlibre.org · Nov 23, 2022, 11:58

Nov 23, 2022, 11:58

Thiago Carvalho @cyrilpedia@social.cleverlibre.org

'At the time, Argentina’s regime, the bloodiest in modern South American history, was rounding up thousands of real and presumed leftists and putting them in torture camps or killing them outright in what came to called the “dirty war.” The dictatorship lasted seven years, during which at least 8,960 people disappeared, according to official estimates. Some human rights groups put the figure at 30,000.'

https://www.nytimes.com/2022/11/22/world/americas/hebe-de-bonafini-dead.html?action=click&module=Well&pgtype=Homepage&section=Obituaries

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**Thiago Carvalho** · Nov 23, 2022, 11:56

Thiago Carvalho boosted

**Giorgio Gilestro** @giorgiogilestro@drosophila.social · Nov 23, 2022, 11:56

Nov 23, 2022, 11:56

Giorgio Gilestro @giorgiogilestro@drosophila.social

Two questions:

1) Does anyone have a reccomendation for a Drosophila anti-SuVar39 antibody?

2) I see this kind of questions becoming more prominent within our community so it may be a good idea to decide on hashtags to be used in the future. I can't think of anything genius right now so I'll go with silly #flyreagents or #flyrequest but feel free to propose something better!

**Thiago Carvalho** · Nov 22, 2022, 19:56

Thiago Carvalho boosted

**Luc Rocher 🍃** @cynddl@mamot.fr · Nov 22, 2022, 19:56

Nov 22, 2022, 19:56

Luc Rocher 🍃 @cynddl@mamot.fr

Hello Mastodon.

I am looking for new PhD students to come work with me at the Oxford Internet Institute in 22/23 (@oiioxford) to study the future of data privacy and digital rights, the impact of AI and algorithms on digital platforms, and help co-create better digital futures.

Boosts very much appreciated! 🐘