Thiago Carvalho @cyrilpedia@social.cleverlibre.org

@awford I hope you like it, thanks for the comments

'From exile, in 1934, (Joseph) Roth wrote, in a furious statement as applicable now as it was then: “The epoch-making discovery of modern dictatorships is the invention of the loud lie, based on the psychologically correct assumption that people will believe a shout when they doubt speech.”

https://www.nytimes.com/2022/11/26/books/joseph-roth-endless-flight-keiron-pim.html

New #preprint from Ardem Patapoutian's lab:

'Here, we show that humans lacking PIEZO2 exhibit impaired bowel sensation and motility. Piezo2 in mouse dorsal root but not nodose ganglia is required to sense gut content, and this activity slows down food transit rates in the stomach, small intestine, and colon. Indeed, Piezo2 is directly required to detect colon distension in vivo. Our study unveils the mechanosensory mechanisms that regulate the transit of luminal contents throughout the gut, which is a critical process to ensure proper digestion, nutrient absorption, and waste removal.'

#Mechanosensing #MucosalImmunology
#Piezo

https://www.biorxiv.org/content/10.1101/2022.11.27.518109v1?med=mas

@awford Protection and a stable supply of nutrients are two possibilities

@awford Yes, a stable symbiotic relationship that is now very much a complete co-dependence.

@awford If you want to know a bit more, this is a good video for a broader audience (but one that is still rigorous and accurate). Mitochondria are essentially domesticated bacteria that our cells use to make energy

https://www.youtube.com/watch?v=WEECyKKgNo0

@awford The makes sense - the excerpt is from a paper aimed at specialised readers (biochemists, cell biologists etc).

In general terms, mitochondria are cellular power stations and they are thought to be important in ageing because burning all that fuel. much like burning fuel in other contexts, has a lot of toxic byproducts.

'Exposição Dinossauros — O Regresso dos Gigantes estará em Lisboa até Setembro de 2023. É uma visita ao maravilhoso mundo dos dinossauros, onde até se pode ser paleontólogo.'

https://www.publico.pt/2022/11/26/ciencia/noticia/dinossauros-invadiram-pavilhao-conhecimento-trazem-novidades-mundo-2027372

"In the year since Mr. Malichudis first read about his own work in another news outlet, the scandal has snowballed. A financial journalist learned he had also been wiretapped. The government of Prime Minister Kyriakos Mitsotakis admitted that the state intelligence service was monitoring an opposition leader. Two government officials, including the prime minister’s nephew, have resigned.

It’s been called the Greek Watergate."

https://www.nytimes.com/2022/11/26/business/greece-journalists-surveillance-predator.html?smid=tw-nytimes&smtyp=cur

"We conclude that, although several ways that induce extended lifespan through mitochondrial dysfunction require a functional mitochondrial unfolded protein response, there is no clear indication that activation of the mitochondrial unfolded protein response is sufficient to extend lifespan, despite the fact that the mitochondrial unfolded protein response impacts almost every aspect of mitochondrial function."

#Celegans #mitochondria #metabolism

https://academic.oup.com/genetics/advance-article-abstract/doi/10.1093/genetics/iyac160/6809022?redirectedFrom=fulltext

On Piezo as an RNA sensor in the gut:

"This is an important study that resolves a controversy about a proposed molecular linkage between the fields of mechanobiology and RNA signaling. While prior research had claimed that a specific mechanosensitive ion channel in the gut responds to a specific fecal RNA, this study provides compelling evidence that the mechanosensitive ion channel does not respond to the RNA."

https://elifesciences.org/articles/83346

#MycoMonday