Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
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That ridiculous time of year when the university expects us to be at work and functioning but the coffee shops on campus are all closed.
Thiago Carvalho
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Hello Mastadon! Here's my #introduction: I'm an Assistant Professor of Biochemistry at the University of Utah specializing in molecular and cellular visualization, particularly 3D animation. We're interested in thinking about how to use visualization in scientific research, communication, education, and outreach. Here's a little montage of animations I've worked on over the years. Do you recognize any?
Thiago Carvalho
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Thiago Carvalho
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#Twitter just suspended an account using *public data* to track the whereabouts of #Musk's private plane.
https://www.cnbc.com/2022/12/14/twitter-suspends-elonjet-account-that-tracks-elon-musks-private-jet-.html
Thiago Carvalho
boosted
Coincidentally (I didn't know this was coming, honest!), a big article was published just today claiming that the motivation to exercise depends on the microbiome of the gut (in mice).
The gist is that certain microbiomes produce chemicals that prevent the breakdown of dopamine in the brain during exercise. And when that happens, mice tend to be more active. Following antibiotics, these effects disappear. But they are restored again once the microbiome is restored.
The potential of this finding, if true: “If we can confirm the presence of a similar pathway in humans, it could offer an effective way to boost people’s levels of exercise to improve public health generally.”
The friendly version:
https://www.pennmedicine.org/news/news-releases/2022/december/gut-microbes-can-boost-the-motivation-to-exercise
The deeper dive:
https://www.nature.com/articles/s41586-022-05525-z
Thiago Carvalho
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Postage stamps are now irrelevant to most people's lives, but it's nice to see the USPS celebrating the microscopic world with these new releases. https://about.usps.com/newsroom/national-releases/2022/1213-usps-reveals-additional-stamps-for-2023.htm
Thiago Carvalho
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New #OpenAccess Parkinson's disease research from LJI scientists Cecilia Lindestam Arlehamn, Ph.D., and Alessandro Sette, Dr. Biol. Sci.
Check out: "Unaltered T cell responses to common antigens in individuals with Parkinson's disease" in the Journal of Neurological Sciences: https://doi.org/10.1016/j.jns.2022.120510
I spoke with the senior author, Matteo Iannacone of #SanRaffaele in Milan for the #EMBOPodcast earlier this year about models for #SarsCov2 research, including dramatic differences between aerosol vs intranasal exposure to the virus in mice - the #pathogenesis of the disease is very different.
https://www.embo.org/podcasts/embo-young-investigators-past-and-present/
An interesting detail in this @biorxivpreprint #preprint from @iannaconelab on the #antiviral Nirmatrelvir is that they (the researchers) produced the molecule in-house:
"Nirmatrelvir was synthesized prior to its publication (4) via a multistep convergent approach that differed from the reported procedure (3, 17, 18). Details and synthesis intermediates are shown in Figure 1A and in Materials and Methods."
'Our structural, genetic, and phenotypic analyses in this large epidemiological cohort reinvigorate the often-neglected interplay between APOE ɛ2 dosage and sex and link APOE alleles to inter-individual brain structural differences indicative of ADRD familial risk.'
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001863
'Fanatical supporters of Brazil’s outgoing president, Jair Bolsonaro, have torched cars and buses and tried to storm the federal police headquarters in the country’s capital in what one commentator called a botched attempt to spark a January 6-style turmoil.
The violence erupted on Monday evening after the leftwing politician who defeated Bolsonaro in October’s historic election – former president Luiz Inácio Lula da Silva – had his victory officially ratified by Brazil’s electoral court.'
@mucida Beleza. Pensei que tava rolando crise existencial.
Thiago Carvalho
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“Pure and deadly greed”: Lawmakers slam Pfizer’s 400% price hike on COVID shots. Senators Warren and Welch urged Pfizer to back down from "unseemly profiteering." https://arstechnica.com/?post_type=post&p=1904335
Thiago Carvalho
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Focal adhesions help endothelial cells get in line
A Research Highlight showcasing new work from Tevin Chau, Anne Lagendijk and colleagues
https://journals.biologists.com/dev/article/149/23/e149_e2302/285925/Focal-adhesions-help-endothelial-cells-get-in-line
We interviewed the authors of the paper, Tevin Chau and Anne Lagendijk, for our 'The people behind the papers' series.
https://journals.biologists.com/dev/article/149/23/dev201441/285916/The-people-behind-the-papers-Tevin-Chau-and-Anne
Read the full #OpenAccess Research Article, ‘Dynamically regulated focal adhesions coordinate endothelial cell remodelling in developing vasculature’ here: https://journals.biologists.com/dev/article/149/23/dev200454/285926/Dynamically-regulated-focal-adhesions-coordinate
Thiago Carvalho
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'Studies with a fluorescent version of Rapalink-1 and a PEG-linked fluorescent marker control showed that such linked molecules in general might be achieving cellular entry via the IFITM proteins, which is a rather surprising result.'
#DrugDiscovery #DrugDevelopment #Interferon
https://www.science.org/content/blog-post/huge-molecules-hitching-ride-cells
'In fact, international interdependence may have made the ongoing war in Ukraine more likely. It’s not obviously silly to suggest that Putin expected Europe to accept the conquest of Kyiv because of its dependence on Russian natural gas.'
https://www.nytimes.com/2022/12/13/opinion/trade-world-peace.html
Thiago Carvalho
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Hi everyone! I'm @basktastic on Twitter but am trying out my real name here. My #chembio #cellbio #lipidtime lab at Cornell develops tools for imaging and editing the lipidome, drawing on #bioorthogonal chemistry, #clickchemistry, #chemoproteomics, #optogenetics, #directedevolution, and more. https://baskin.wicmb.cornell.edu
Thiago Carvalho
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Let's celebrate the season with a bit of science! Starting a daily countdown of 10 modern and fascinating ideas about the brain for us all to discuss. How likely is this to be true? And if true, what are the implications?
Brain idea 10: Our moods may depend not just on what's happening in our brain, but also our gut. The gist of the idea is that the gut can send distress signals to the brain that can trigger fear and anxiety.
The friendly summary:
https://www.health.harvard.edu/diseases-and-conditions/the-gut-brain-connection
The deeper dive:
https://www.frontiersin.org/articles/10.3389/fgstr.2022.1019578/full
#neuroscience
(And despite my reluctance; because I'm trying to work out the hashtag habit here ...)
#BrainIdeasCountdown
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
