Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
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"When you hate ..."
Bertrand Russell (1954)
“When you hate, you generate a reciprocal hate. When individuals hate each other, the harm is finite; but when great groups of nations hate each other, the harm may be infinite and absolute. Do not fall back upon the thought that those whom you hate deserve to be hated. I do not know whether anybody deserves to be hated, but I do know that hatred of those whom we believe to be evil is not what will redeem mankind.”
— Bertrand Russell
@azzurite This is much more expensive than making a small molecule drug or a biological like a monoclonal antibody. But nothing to justify a price tag like this.
@paulmyoung@newsie.social I heard that in Rome if you ask for catchup for your pasta they leave you in the Colosseum and release the lions
Thiago Carvalho
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TATTOO-seq delineates spatial and cell type–specific regulatory programs in the developing limb #singlecell #devbio #SpatialTranscriptomics
https://www.science.org/doi/10.1126/sciadv.add0695
@meyer@mstdn.science I feel validated
@paulmyoung@newsie.social Correct - hotel staff in Paris keep a select number of rooms with views of the Montparnasse Tower to punish unruly or unpleasant guests.
'But the authors are particularly set off by the habit of referring to the unfolded state as some sort of unique form common to most proteins, whether this unfolding is done by excess heat, lack of heat, pressure changes, chemical means, or whatever.
I can see their point. This is an example of “reification”, the philosophical mistake of “turning something into a thing” when it isn’t actually a separate entity or even a real one.'
cc @pradeu
https://www.science.org/content/blog-post/unfolding-unfolded
Thiago Carvalho
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I am reading Bianchi's classic from 1895, "The functions of the frontal lobes", and I love the introduction ("with wholly unprejudiced mind, I began...") and the method of testing the electrical current ("I used to test the strength of current on my tongue"). The latter is clearly unhealthy, but even a few years ago the process for getting a gigaseal was somewhat similar... (yuck).
https://doi.org/10.1093/brain/18.4.497
What's in a name?
'One of the simplest ways to classify proteins is into bins called “folded” and “unfolded”, and many of us slide into that shorthand when describing them. But it’s too simple. There are proteins that adopt a consistent three-dimensional structure that is nonetheless wrong, which are better categorized as “misfolded”, and there are proteins that have distinct regions (or sometimes the whole protein) that never adopt such a fixed structure at all, which we generally call “disordered”.'
https://www.science.org/content/blog-post/unfolding-unfolded
Thiago Carvalho
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What controls dynamic #Epithelial-to-#Mesenchymal Transition of #cancer cells?
Peter ten Dijke Lab at LUMC Leiden identify #plasmamembrane #glycosphingolipid composition and expression of their biosynthesis enzymes as key determinants of dynamic #EMT and #malignant transformation in human #epithelia
Thiago Carvalho
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ok, left twitter. now here.
looking forward to having lots of great interactions here!
Thiago Carvalho
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RT @ramundo_silvia
ASAPbio competition: Make your negative result a preprint winner – ASAPbio https://asapbio.org/competition2022
"CSL’s Hemgenix costs $3.5mn per dose, which makes it the most expensive drug in the world. Skysona and Zynteglo, which are gene therapies targeting a rare childhood brain disease and an inherited blood disorder, developed by the Cambridge, Massachusetts-based biotech Bluebird Bio, are the second- and third-most expensive drugs on the market. They are priced at $3mn and $2.8mn per dose, respectively."
#GeneTherapy #DrugDiscovery #DrugDevelopment #haemophilia
#raredisease
https://www.ft.com/content/8173d816-1167-4773-bad5-f565fed3ffde
Thiago Carvalho
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Hello #ScienceMastodon. Journal of Experimental Biology #J_ExpBiol is an online #journal published by @Co_Biologists. Led by Editor-in-Chief Craig Franklin, we publish research across the breadth of the #comparativephysiology #biomechanics and #neuroethology.
We’ll be tooting about our #research papers, #interviews and #editorials We’re also committed to supporting early-career researchers, so we’ll be sharing information on our initiatives for #ECRs.
Thiago Carvalho
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Looking for a 2 year postdoc to work with ancient 🦴 and modern genomes 🧬 of sheep 🐑 and their wild/feral relatives? We might have something for you!
Come join us @HumanEvoUU Application deadline is Jan 23rd.
Thanks for sharing!
More info: https://gunther-lab.org/postdoctoral-fellowship-in-sheep-population-genomics/
Thiago Carvalho
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It is my pleasure to announce we are organising a workshop on #Reproducibility in #CancerBiology in Bordeaux, January 11th, 2023.
The speakers will be:
- Timothy Errington, from the Center for Open Science
- Marcus Munafò, Univ. Bristol and UK Reproducibility Network
- Jacob Stegenga, Univ. of Cambridge
- Dawn Teare, Univ. Newcastle
- Frédéric de Lamotte, INRAE, Montpelier
...and yours truly.
Feel free to boost.
#Cancer #CancerResearch #OpenScience
https://oncospheremeeting.com/workshop-on-reproducibility-in-cancer-biology/
Thiago Carvalho
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Thiago Carvalho
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Loving the Internet Archive Scholar @scholar
For the paper below offers links to an archived PDF and to the publisher's website, and it writes:
"A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL."
"Integration of GABAergic Interneurons into Cortical Cell Assemblies: Lessons from Embryos and Adults", Giorgia Bartolini, Gabriele Ciceri, Oscar Marín 2013
https://scholar.archive.org/work/ons6xjtpxbesvlmhr4eh7aumcu
Thiago Carvalho
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Dr. Anthony Fauci: A Message to the Next Generation of Scientist - a guest essay written for the New York Times as he prepares to retire from the NIH this month.
“I share my story, one of love of science and discovery, in hopes of inspiring the next generation to enter health-related careers."
#Science #Fauci #Health #Medicine #Immunology #Covid19 #HIV #PublicHealth
"‘Dear colleagues, we should all work on the same strain because, soon, we will sequence the genome of Listeria’. At that meeting, I had brought samples of the strain on which we were working to give to everybody – and I came back with all my samples! Nobody was interested because, I think, they did not believe me. After we obtained a significant budget, it still took us two years – and we were six groups – to sequence the genome of #listeria monocytogenes (Glaser et al., 2001)."
Pascale Cossart @DMM_Journal
#Microbiology #Parasitology #Genomics
https://journals.biologists.com/dmm/article/15/12/dmm050009/285917/
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
