Thiago Carvalho @cyrilpedia@social.cleverlibre.org

Hey everyone!

My name is Jason Kirk and I am the director of the Optical Imaging & Vital Microscopy core facility at the Baylor College of Medicine in Houston, TX.

I am a microscopist and photographer interested in all things imaging. I am a big proponent of microscopy education and frequent poster of #FluorescenceFriday images.

Speaking of #FluorescenceFriday - here is my first Mastodon image:

Now imagine you’re the governor of the state with the country’s largest population over 65. Perhaps you’d want to make sure that you’re protecting your state’s seniors from falling into that gap. Except that governor is Ron DeSantis of Florida, who just proved, yet again, that he is America’s most cynical elected official, exploiting pandemic-era foolishness to further vaccine mistrust simply for political gain."

#COVID #Vaccine

https://newrepublic.com/article/169568/ron-desantis-pandemic-mccarthyism-vaccine?utm_source=newsletter&utm_medium=email&utm_campaign=tnr_daily

Just arrived here. Still not sure how this works though.. #science #immunology #HSCT #treg #lymphocytes #celltherapies #immunemodulation #CMV #GVHD will all these #s help me to get content I'm keen on?

A few years ago we showed that restriction-modification systems shape gene flow within species. Now we show how plasmids cope with these systems to spread across bacterial populations. Small plasmids avoid restriction sites, large plasmids recruit counter-defenses (methylases). And the plasmids most avoiding restriction sites have the broadest host ranges. Great collaboration in a project led by Liam Shaw and Craig MacLean. https://www.biorxiv.org/content/10.1101/2022.12.15.520556v1

ICYMI: this week has seen a bumper crop of posts on Node.
Thanks so much to all the contributors.

Student reports: https://thenode.biologists.com/tag/summer-studentship-2022/

Day in the life: https://thenode.biologists.com/a-day-in-the-life-of-a-trichoplax-lab/lablife/

Behind the paper: https://thenode.biologists.com/behind-the-paper-using-optoshroom3-to-alter-organoid-shape-with-light/research/

Conference news: https://thenode.biologists.com/tag/conferences/

Preprints in November: https://thenode.biologists.com/november-in-preprints-7/discussion/

Genetics unzipped podcast:
https://thenode.biologists.com/genetics-unzipped-2022-unzipped/outreach/

@Dev_journal Pathway to Independence programme: https://thenode.biologists.com/developments-pathway-to-independence-programme/news/

Jobs at @Co_Biologists: https://thenode.biologists.com/job-opportunities-at-the-company-of-biologists-2/news/

Join us and the Harvard Medical School Center for Bioethics online or in Boston for a Neurotech Justice Summit on Jan. 24, 9am-12pm ET. At the summit, participants together with panelists will examine the meaning of "neurotech justice," its interplay with neuro-rights, and how a focus on justice can positively shape the trajectory of #neurotechnology development and application.
Register here (for both Zoom and in-person options): https://harvard.zoom.us/webinar/register/WN_tceptXK6QZmLmWP0juBdxA #neurosociety #neurotech #bioethics

Many of the journalists Elon suspended today on Twitter are here on #Mastodon. Please follow and boost:

Drew Harwell, Washington Post
@drewharwell

Donie O’Sullivan, CNN
@donieosullivan

Steve Herman, VOA
@w7voa

Micah Lee, Intercept
@micahflee

Tony Webster
@tony

Matt Binder, Mashable
@MattBinder

#freepress #journalism #journalists #news

The 1940s were the Wild West of nuclear physics at Los Alamos. One scientist was doing criticality experiments with a plutonium core where the only tool preventing the beryllium shield from dropping over the core and making it go critical was a screwdriver held in his hand. The screwdriver slipped and the scientist received 10 Grays of radiation. He didn’t live much longer.

https://en.m.wikipedia.org/wiki/Demon_core

#weirdhistory #science #nuclearphysics

Do you use #AAV vectors for #genetherapy or research?

If so, your virus probably isn't as pure as you imagine.
We showed that using standard production techniques, the incorporation of plasmid DNA contaminants directly upstream of the AAV P5 promoter.

When you conduct gene transfer, these sequences are transferred and can be transcribed, translated, and potentially immunogenic!! 😬😬

Core message: Find a way to reduce or remove P5 related contaminants from your AAV

https://www.cell.com/molecular-therapy-family/methods/fulltext/S2329-0501(22)00009-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2329050122000092%3Fshowall%3Dtrue

Sweden

Hey hadn't they reached
"herd immunity" like 18 months ago? 🤡

People don’t realize it but Van Gogh was metal.

GRAVEYARD GUN (c.1820) - used to prevent bodysnatchers from stealing corpses to sell to anatomists. Set at the foot of a grave, the gun would have had three tripwires around it. One such gun reportedly killed a grieving father by accident. Coffin collars, fixed around the necks of a corpse and bolted to the bottom of a coffin, were also used to keep bodies in their graves.

Follow me for more #WeirdHistory!

#HistMed #HistSci #TIL #TheMoreYouKnow #Histodons #Introduction #Histodon #History

And the 9th grade students finishing their observation week @inp_marseille@twitter.com made nice bioluminescent artworks with Nadia Merad Coliac!

Foi um dos maiores massacres coloniais. Há 49 anos, tropas portuguesas assassinaram a sangue frio mais de 300 pessoas em Moçambique.

O historiador Mustafah Dhada resgatou esta história que por pouco ficava ocultada para sempre, e já a contou em dois livros.

Lê tudo em: https://setentaequatro.pt/entrevista/o-massacre-portugues-de-wiriamu-escrever-para-nao-esquecer

I'm trying to return to Mastodon.

I'm an Associate Professor at Universidade Federal de Minas Gerais (UFMG, Brazil), where I teach the history of economic thought, economic methodology and political economy.

I'm currently the Dean of the Faculty of Economic Sciences at UFMG.

My research interests are in the political economy and moral philosophy of the Scottish Enlightenment and in Marx's critique of political economy.

#economics #history #econtwitter #introduction #academic

Engineering a “detect and destroy” skin #probiotic to combat methicillin-resistant #Staphylococcus aureus
#mrsa #amr
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0276795