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Preservation of mitochondrial membrane potential is necessary for lifespan extension from Dietary Restriction in C. elegans

#aging #Celegans #preprint #mitochondria

biorxiv.org/content/10.1101/20

'China’s elites are stockpiling supplies of , Pfizer’s Covid-19 antiviral drug, and giving it away to curry favour with business associates as an unprecedented Covid wave sweeps the country, leaving hospitals stripped of resources and ordinary people struggling to access medication.'


ft.com/content/0687def9-585f-4

Happy Birthday to Hungarian-American mathematician Johnny von Neumann, born #OnThisDay in 1903!
"Johnny did indeed imagine the first draft of the future, and we are now living it" -- Philip Ball

For more on his lost legacy grab 'The Man from the Future'
"Splendid . . . a whistle stop tour through von Neumann's restless mind" -- Manjit Kumar ― Guardian

US wwnorton.com/books/the-man-fro
UK penguin.co.uk/books/313705/the
Also in Romanian, Spanish, Dutch and in many more languages in 2023.

After sufficient lurking, here is my #introduction

I’m a #computational #cognitive #neuroscientist and asst. prof. at JHU Cog Sci studying social vision. Our lab uses a combination of human behavior, neuroimaging and computational modeling to understanding how humans can so effortlessly extract rich social information from the visual world around them.

Our recent work relies heavily on naturalistic neuroimaging and state of the art modeling (such as graph neural networks and disentangled representation learning). You can learn more/find papers on our website: isiklab.org

Science question: how quick can be the development of a hACE2 mouse model? 

stuartritchie.substack.com/p/s the idea that a scientific paper needs to read like “a nice story” is the worst thing we, and the top “vanity journals” have taught - a disservice to science #philosophyofscience #metascience

Science question: how quick can be the development of a hACE2 mouse model? 

Science question: how quick can be the development of a hACE2 mouse model? 

Hello #ScienceMastodon,

How fast could have been the development of the hACE2 mouse model described in cell.com/cell-host-microbe/ful ?

Context: the speed argument was used by the US National Security Council to argue for a lab leak. I'd like to fact-check this.

[It is a question I would have asked on Twltter back in the days; please boost to help me reach the relevant people! - thanks]

@Rahimilab Avery actually got passed over twice, with two different discoveries, for the same reason (a putative protein contaminant).- Here's a good article about it jbc.org/article/S0021-9258(19)

Comparative effectiveness of four COVID-19 vaccines, BNT162b2 mRNA, mRNA-1273, ChAdOx1 nCov-19 and NVX-CoV2373 against SARS-CoV-2 B.1.1.529
#covid19
mRNA kicked the ass of adenoviral/nova vax, but 6 months old news & limited by the few nonRNA participants. medrxiv.org/content/10.1101/20

@leslore Such a great book - and pre Smily Alec Guiness in a great movie. LeCarre basically rewrote it as The Tailor of Panama, but Greene's book is better

@Rahimilab I wasn't aware of that detail - in the context of DNA, the posthumous issue is also pulled out to justify why Avery did not receive the prize.

@cyrilpedia Great article. Thanks for sharing. I can’t remember where I read it, but someone pointed out that there is always the same mistake in all articles about Franklin. The statement that Franklin could not win the Nobel prize because they are not given posthumously is incorrect. The Nobel committee didn’t institute that statute/rule until 1974. They had given the prize to others after death. They just snubbed her.

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