Thiago Carvalho @cyrilpedia@social.cleverlibre.org

Time for an #introduction

I'm a computational (bio)physicisct and have mostly worked with MD simulations of lipid membranes and membrane proteins but also some experience in machine learning and free energy calculations.

Currently I work as a senior scientist at Schrödinger in New York City, after doing a postdoc at Stanford University and a PhD at the Max Planck Institute of Biophysics.

Besides work, I'm an avid amateur photographer and I like reading about science, history, and languages.

Happy New Year everyone!

ICYMI, my review of the year in neuroscience makes for perfect slumped-on-sofa brain food

https://link.medium.com/pIAaQEr57vb

#Introduction
Hi all, I'm finally introducing myself in this new year of 2023! I am a postdoctoral researcher doing #neuroscience, often with a theoretical angle. My own work tends to focus on neural network dynamics, network architecture and (pre)motor control, but my interests are broad and I am trying to use Mastodon to broaden them even more! I also have a special interest in sociology, especially the sociology of #academia. I'm looking forward to learning from the other users, and to communicating about my own research!

An interesting explanation about the federated infrastructure behind Mastodon, with challenges and promises ahead https://arstechnica.com/gadgets/2022/12/mastodon-highlights-pros-and-cons-of-moving-beyond-big-tech-gatekeepers/

Multistep diversification in spatiotemporal bacterial-phage coevolution

"These results highlight the importance of spatial structure and migration for driving phage-bacteria coevolution,..."

https://www.nature.com/articles/s41467-022-35351-w

#phages #viruses #virology #coevolution

There was a quote by a classic developmental biologist - possibly R. Harrison - to the effect that normal development is like a magic trick: as long as it goes well, you learn very little. But when a magician makes a mistake, that's when you get insight into how everything works. Anyone have a reference to the actual quote?

Amazing discovery: how motor neurons come to control fast and slow muscles!

Q: How do developing motor neurons decide to be "fast" (controlling fast-twitch, or "sprinting" muscle fibers) or "slow" (endurance)?

A: Genes called transcription factors determine fast motor neuron "fate." Losing factors make fast neurons project to slow muscle & express "slow motor neuron" genes!

Work from my & Jeremy Dasen's lab: https://www.biorxiv.org/content/10.1101/2022.12.23.521820v1

Pls boost -- trying to beat that other site 🤷🏻‍♂️😝.

“In America, a country that can often be cruel to its citizens, the public library is a surprising kindness. It is institution that offers grace and sanctuary, and a vision of what our country might one day be.”

https://www.theguardian.com/commentisfree/2022/dec/28/usa-public-libraries

Mastodon friends! I will probably post this over on twitter next week, but you're special people and get a sneak peek :) We're hiring a bioimage analyst in my team! This is a "junior" position best suited for someone who knows an image analysis tool or two, can code to a novice/intermediate level, and wants to learn a lot. Remote work (in the US) possible depending on circumstances. Please share widely! https://thejacksonlaboratory.wd1.myworkdayjobs.com/External_JAX/job/Farmington-Connecticut/Systems-Analyst-I_JR002913

First substack post: how to to do good ecological research: 10 points

In these newsletter posts I am developing ideas, some of which could result in papers. If you are interested in contributing: please leave input as a comment in substack.
https://matthiasrillig.substack.com/p/how-to-do-good-ecological-research

This piece made me wish i was in London, able to visit "Alexander the Great: The Making of a Myth", at the British Library--ht to @cyrilpedia
https://www.lrb.co.uk/the-paper/v45/n01/james-romm/at-the-british-library

Kudos to Jennifer Raff for this wonderful summary of the current state of knowledge of human entry into the Americas, synthesizing genetic data with exciting new archeological evidence of human footprints from White Sands NM, potentially 23K years ago 1/2
https://aeon.co/essays/the-first-americans-a-story-of-wonderful-uncertain-science?utm_source=pocket-newtab

New cross-journal article collection on #aging & #senescence - why not add a new browser tab to your holiday reading list?

👉 https://www.embopress.org/page/collections/aging-senescence-2022

#genome stability
#chromatin
#metabolic plasticity
#tau aggregation
#telomere dysfunction #immunoaging

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