Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
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We could now look at how exactly the cells encoded fish location. We started with area SLO-MO. Individual cells there showed fairly complex dynamics, but on top of that integrated visual velocity so they represented fish location. This also worked in 2D
8/n
The irritable substance does not forget.
'In 1904, Richard Semon (7) proposed the idea of the “engram” and defined it as “the enduring though primary latent modification in the irritable substance produced by a stimulus (from an experience).”
https://www.jbc.org/article/S0021-9258(22)00306-4/fulltext#.Y7GgPgqpdhA.twitter
Robert Caro's essentials
"2. My Typewriters I write my books not on a computer but on a Smith Corona Electra 210. They stopped manufacturing them about 30 years ago, but I have accumulated some. You need spares because when a part breaks on the one you’re using, you have to cannibalize the part from another one. When I have a book coming out, and newspaper profiles mention that I use them, people send me their old ones that were stored away years ago. Thanks to this generosity, I had 14 of them three years ago. I’m down to 11 already."
https://www.nytimes.com/2023/01/01/movies/robert-caro-turn-every-page-documentary.html
Cellular heterochronicity
"Neurons with longer timescales show higher response selectivity for temporally extended computations such as decision making and reward integration, whereas shorter timescale neurons are implicated in sensory processing."
#Neuro #Neuroscience #preprint
https://www.biorxiv.org/content/10.1101/2023.01.01.522410v1?med=mas
Thiago Carvalho
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Two new review/opinion pieces are online!
Antibacterial #resistance is one of the greatest threats to #human #health.
Rolf Müller and co-workers from the Helmholtz Institute for Pharmaceutical Research Saarland and the Helmholtz Centre for Infection Research highlight the challenges, advancements and current standing of the clinical and preclinical antibacterial research pipeline. #bacteria #antibiotics
Thiago Carvalho
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Ha! @megalithic just followed me and made my day because I discovered the website https://megalithic.co.uk , an index of megalithic sites. Definitely going to check some out here in Switzerland.
Thiago Carvalho
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88. Takinogawa in Ōji, 1857 #hiroshige #utagawahiroshige https://www.wikiart.org/en/hiroshige/88-takinogawa-in-oji-1857
Thiago Carvalho
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RT @DukeBrain@twitter.com
Did you know that @DukeU@twitter.com undergrads doing a senior thesis can get *paid* to do brain sci research over the summer? Check out the Summer Neuroscience Program co-sponsored by DIBS + @DukePsychNeuro@twitter.com and apply soon! Applications for close Feb. 3rd.
🔗 https://dibs.duke.edu/education/undergraduate/summer-neuroscience-program/
🐦🔗: https://twitter.com/DukeBrain/status/1603093558919331840
Thiago Carvalho
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No 10 says #NHS is getting ‘funding it needs’ and refuses to accept service is ‘in crisis’ – UK politics live
I see we haven't moved on from lies and delusion. #politics #ukpolitics
On patient reported outcomes in adoptive cell therapy.
"Interestingly, only 6.8 % of the recently published CAR-T trials investigated PROs as a primary or secondary outcome measure,6 and none of the TIL-ACT clinical trials in solid tumors included PROs as corollary endpoints. Indeed, much of academia’s and industry’s efforts to date have been aimed at shifting the cost-effectiveness balance of these therapies by understanding biological features of efficacy (cancer target identification, T-cell product characteristics, biomarkers of response, etc), improving the manufacturing pipeline, and scalability. Surprisingly, limited efforts have been directed to understand patients’ perspectives during cell-therapy trials."
#AdoptiveCellTherapy #PatientReportedOutcomes #immunotherapy #ClinicalTrials #DrugDevelopment
Thiago Carvalho
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🔥🔥🔥9 open PhD positions available in the newly established
@dfg_public
Research Unit on Physiological Causes and Consequences of Genome Instability 🧬. Join the thriving research environment in Cologne, Germany
@CECAD
@unicologne
@MPIAGE 🔥🔥🔥
As Charles said "From so simple a beginning..."
(Fm David Quammen's "Breathless: The Scientific Race to Defeat a Deadly Virus.")
Thiago Carvalho
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And yes, please use hashtags with gusto here!
Don't be shy, we want to hear from everyone!
Thiago Carvalho
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Thiago Carvalho
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To be considered by Lego for production, my Ideas submission needs to gather 10,000 votes. If you'd like to see this set of arthropod model organisms available for purchase, please vote here and share among your friends and colleagues:
Thiago Carvalho
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Including comments from #telomerase researcher Miguel Godinho Ferreira at IRCAN Nice and @embojournal genome stability & dynamics editor @HVodermaier
Re-read the original article for free in our #anniversary collection:
https://www.embopress.org/page/journal/14602075/focus/40th-anniversary
Thiago Carvalho
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...in which I discuss the value of exceptional purely descriptive studies without "mechanism", and what it takes for them to get visibly published nevertheless
Thiago Carvalho
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Thank you to EMBO & Thiago (@cyrilpedia) for the honor of commenting on the seminal discovery of ALT by two of my favorite scientists from downunder. Congratulations Roger Reddel and Tracy Bryan. You continue to inspire me!
#telomere #ALT #cancer @embojournal
A paper that I was not aware of in @embojournal that scientific editor @HVodermaier mentioned in the #telomerase independent immortalisation discussion on the latest #EMBOPodcast episode is the finding from Lackner, Karlseder et al in #EMBOJournal 2012 of a very interesting ALT system in #Celegans
🎧 to the episode
https://www.embo.org/podcasts/alternative-immortality/
Read the paper (#OpenAccess)
https://www.embopress.org/doi/full/10.1038/emboj.2012.61
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
