Thiago Carvalho @cyrilpedia@social.cleverlibre.org

To Any Recently Laid-off Tech Workers,
If you have strong ML/Python skills, consider applying this position in my lab at MIT:
https://careers.peopleclick.com/careerscp/client_mit/external/jobDetails/jobDetail.html?jobPostId=25473&localeCode=en-us
The pay is lower and the free food not as fancy, but we do cool research on the human brain and have a lot of fun. And I have a near-perfect record helping my lab techs get into top Ph.D. programs in cog sci/ neuroscience.
Check us out here: https://web.mit.edu/bcs/nklab/index.shtml

Bioinformatician Open Rank Faculty

University of Alabama at Birmingham is seeking applications for a tenure-track faculty position in genomics, bioinformatics, and computational biology

https://jobrxiv.org/job/the-university-of-alabama-at-birmingham-27778-bioinformatician-open-rank-faculty/?feed_id=34928

#ScienceJobs #job
Birmingham #Unit...
https://jobrxiv.org/job/the-university-of-alabama-at-birmingham-27778-bioinformatician-open-rank-faculty/?feed_id=34928

🦠
"As of 2 December 2022, over 82,000 human mpox (or monkeypox) cases have been laboratory confirmed in 110 countries worldwide."

And sporadic reports are still coming in:
https://c.im/@andrew_a_lover/109673550181706348

This may be what a very very very slow pandemic looks like.
🦠
As a step towards the development of antivirals, (Peng et al., 2022) recently elucidated the structure of the mpox DNA polymerase:

"Structure of monkeypox virus DNA polymerase holoenzyme"
https://doi.org/10.1126/science.ade6360
#virus #virology @virology

Worried that my AI spellchecker has achieved sentence

Immune sensing of food allergens promotes aversive behaviour

https://www.biorxiv.org/content/10.1101/2023.01.19.524823v1.full.pdf

After years of silently lurking around Twitter, I finally decided to say #hello to the community with a short #introduction.

I am a postdoc at #wwu University of #Münster pretending to know something about #microbialgenomics 🧫 . In my PhD I did research on #zoonotic pathogens 🐷 🐣 . More recently, I am trying to learn #metagenomics 🧬 .

Currently, I am also administrator of miGenomeSurv, a platform to harmonize genomic #surveillance in Germany https://www.migenomesurv.org.

“Who is original? Everything that we are doing, everything that we think, exists already, and we are only intermediaries, that’s who make use of what’s in the air.” – Henry Miller

#writingcommunity #writerscommunity #writing #storytelling #screenwriting #writingtips #creativewriting #writinglife #HenryMiller

Research Technician, Neurology, Alzheimer's Disease Research Unit

Research technician, Brad Hyman Lab @MGHNeurology in Boston, MA, USA. Using biochemistry to study tau in Alzheimer’s Disease

https://jobrxiv.org/job/massachusetts-general-hospital-27778-research-technician-neurology-alzheimers-disease-research-unit/?feed_id=34872

#ScienceJobs #job
Boston, MA ...
https://jobrxiv.org/job/massachusetts-general-hospital-27778-research-technician-neurology-alzheimers-disease-research-unit/?feed_id=34872

Bat, lithographic print on limestone, 12x14cm

https://madalenaparreira.com/Objects-and-ceramics

An illustration that Madalena Parreira made for an interview I did with Leonard Zon for the now defunct JEM blog "Dr Flexner's Suitcase".
https://madalenaparreira.com

"The importance of stupidity in scientific research"

I just rediscovered this classic paper. Highly recommended, particularly for #PhD students!

"Science makes me feel stupid too. It’s just that I’ve gotten used to it. So used to it, in fact, that I actively seek out new opportunities to feel stupid. I wouldn’t know what to do without that feeling. I even think it’s supposed to be this way. Let me explain."

https://journals.biologists.com/jcs/article/121/11/1771/30038/The-importance-of-stupidity-in-scientific-research
Martin A. Schwartz, Journal of Cell Science 2008

#Science

#Invitro #reconstitution assays with purified brain #tubulin from mouse models lacking specific tubulin-modifying #enzymes show that tubulin #polyglutamylation patterns differentially regulate #microtubule-interacting protein binding

Carsten Janke, Marcus Braun and coworkers
https://www.embopress.org/doi/10.15252/embj.2022112101

Last chapter in our #40yearsEMBOJ highlight series: ALTernative #immortality

Listen to Roger Reddel and Tracy Bryan telling @CyrilPedia about their discovery of alternative #lengthening of #telomeres, ALT, in their 1995 @embojournal paper
https://www.embo.org/podcasts/alternative-immortality/

#ALT (not #telomerase) repairs damaged telomeres in #iPSCs… 😳 This finding comes in a sequences of others recognizing different
rules for #DNAdamage detection, #checkpoint activation and even #DNA repair in undifferentiated cells. 🧬👍
“Our findings suggest a previously unappreciated role for ALT in telomere maintenance in telomerase-positive iPSCs and reveal distinct iPSC-specific responses to targeted telomeric damage.” https://www.biorxiv.org/content/10.1101/2023.01.19.524780v1