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'In the decade since the publication of CRISPR-Cas9 as a genome-editing technology, the CRISPR toolbox and its applications have profoundly changed basic and applied biological research. Wang and Doudna now review the origins and utility of -based genome editing, the successes and current limitations of the technology, and where innovation and engineering are needed.'

science.org/doi/10.1126/scienc

#AI is going to challenge all sorts of ways we do things at the moment. Not necessarily for the worse, but we will have to review processes and their outputs differently.

PRISMA AI reporting guidelines for systematic reviews and meta-analyses on AI in healthcare | Nature Medicine

nature.com/articles/s41591-022

"However, despite deep knowledge about the genomic drivers of cancer—from oncogenic mutations to chromosomal rearrangements—we do not yet know how the spatial arrangement of the tumor microenvironment (TME) impacts pathogenesis; for instance, which feature types and spatial scales are relevant, how disease-associated histological features relate to molecular states, and whether morphological differences are discrete (like mutations) or continuous (like morphogen gradients)."

sciencedirect.com/science/arti

This is supposed to be a feel-good story.

It’s actually a parable for how horrible the health care system is in the United States.

washingtonpost.com/lifestyle/2

𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀 𝗮𝗻𝗱 𝗲𝘅𝗽𝗹𝗮𝗻𝗮𝘁𝗶𝗼𝗻𝘀.
Join the Neuroscience & Philosophy Salon for a discussion with Johannes "Yogi" Jäger @yoginho.

Are networks really enough to "explain" biological systems (yes, that includes brains!) ???
When: Thu Feb 2 at 12pm US-EST.
Discussion open to all and link to follow.

Check some of our previous salon discussions here:
youtube.com/@neurosciencephilo

"2. Thou shalt not pseudoreplicate or otherwise worship false degrees of freedom."

From @RELenski The Ten Commandments of Statistical Inference

telliamedrevisited.wordpress.c

Imagine being such a cruel, twisted, soulless, corpse-like shell, such a degraded, sociopathic bigot, that you squander your time on Earth trying to rile up hatred against love itself - and attribute your vileness to a teacher whose message was: "Love your neighbor as yourself." #LGBTQ

I asked the #AI tool #DALL-E to paint "Activation of the immune system" in the style of Dali, Matisse, and Picasso. Here they are! The first one is Matisse (see thread for others...) #sciencemastodon #AI #science #art #artificialintelligence

Sunday #Plankton #Factoid 🦐🦠
Cladoceran "water fleas" are characteristically parthenogenic: all female populations producing clones of themselves. However under stress or end of season, they hatch males which mate to produce hard resting eggs called ephippia, so tough they can survive *centuries and be viable, introducing genetic variation. This created a new field of study termed "resurrection ecology" by Kerfoot and Weider who hatched them in lab from sediment cores.
aslopubs.onlinelibrary.wiley.c

'“Decisions about health and human flourishing are too often decided without directly impacted people at the table, but it's critically important to build trust by our voices being part of the conversation, in order to understand why and what drives the reluctance we may have to trusting the healthcare system,” said DeAnna Hoskins.'
HT @gregggonsalves

medicine.yale.edu/intmed/news-

@SteveBHolt Great point, about time that such core academic service is transferred back to university libraries where it belongs. For the time being, there’s scholar.archive.org (a charity organisation) which works pleasantly well, and doesn’t play the game of citations and h-index and similar rubbish metrics of academic performance, focusing instead on archiving and ensuring access to the papers.

Alienated academics:

A qualitative interview study finds that a merger between two Finnish universities produced different types of alienation among staff.

Poutanen (2022) - Open access: doi.org/10.1080/02680939.2022.

Four (depressing) quotes follow 🧵👉

#OrgBehavior
@orgbehavior
#HigherEducation
#HigherEd
#EducationPolicy
#AcademicChatter
@academicchatter
@academicsunite

1/5

“Read not to contradict and confute; nor to believe and take for granted; nor to find talk and discourse; but to weigh and consider.”

Francis Bacon, born on this day in 1561, on learning and how to read intelligently themarginalian.org/2012/07/13/

RT @Bob_Fernandes
Ex-juiz, ex-ministro, ex-Catão, ex-herói verde amarelo, Moro paralisou a demarcação das Terras Indígenas e entregou a FUNAI para o que havia de pior. É um dos grandes responsáveis pela tragédia humanitária nas terras Yanomami.

You’re a postdoc in neuroscience, ecology or any field related to our research? Apply now and give a talk in our emerging scientist talk series! The talks will be held in our institute and you will have an opportunity to present and discuss your topic with our faculty and institute members. Travel and accommodation charges will be covered.
Apply by March 1st: bi.mpg.de/2599696/postdoc-semi

#mpiforbi #maxplanck #maxplanckinstitute #research #Science

#migration#re-Introduction.

I'm a theoretical neuroscientist at U Mainz Medical Center and co-affiliated with U Bonn Medical center. Primary focus on cortical circuits, their network activity, synaptic plasticity and protein dynamics in dendrites. Broadly interested how circuits learn e.g. neuro/AI interface and want to understand how neural networks compute, both algorithmically and intracellularly. Occational posts about societal and academic issues.

Kicking off 2023 with a celebration of #SciArt by @somedonkey 🎉​. This piece is featured as the current cover of @TrendsNeuro. Let me highlight what Julia has done here ...

The context is an article by myself and @amygdaloid arguing that what the brain does is complicated and difficult to describe. But it's also crucial to get these descriptions right, given that what we figure out about the brain rests on these definitions.

Julia brilliantly captures this complexity by embedding some wonderful illustrations in a larger piece depicting what we, as a field of brain researcher sleuths, are trying to do here.

First have a look at the whole and then let me give you a tour of some of its bits ...

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