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We’ve kicking off the 2023 season of #DevPres with a webinar hosted by Paul François on theoretical and computational #modelling of #devbio. Join us on Wed 25 Jan 15:00 GMT to hear talks from Kirsten ten Tusscher, Simon Freedman and Mindy Liu Perkins.

us02web.zoom.us/webinar/regist

@AdaraAstin Not sure, this is preclinical work - but if I'd had to guess, I'd say that a belt + suspenders approach will be the way to go, at least to start

James W. Truman and Lynn M. Riddiford just published a magnum opus on:

"#Drosophila postembryonic nervous system development: a model for the endocrine control of development" academic.oup.com/genetics/adva

Touches upon insect insulin-like peptides, hormonal control of neuronal growth, metamorphic fates of larval neurons, pruning and its induction by ecdysteroids, remodelling, postembryonic neurogenesis and neuronal fate determination, CNS plasticity in cell composition, apoptosis.

Spectacular!

@thelancet Risk of #autoimmune diseases in patients with #COVID19: A retrospective cohort study : This study provides a closer insight into the association between #COVID19 and autoimmune diseases and reveals discrepancies across sex, age, and race of participants.
sciencedirect.com/science/arti

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@gpollara @vivek_mutalik

That's a great question - the ability to attack bugs in biofilms was a big plus of phage therapy when we discussed it on the precisely because traditional drugs were so bad at targeting them there embo.org/podcasts/the-enemy-of

"To prepare for future outbreaks, the disease-modeling community can improve their modeling capabilities by learning from the methods and insights from another arena where accurate modeling is paramount: the weather and climate research field."
cc @gregggonsalves @lmrocha

pnas.org/doi/10.1073/pnas.2209

"While the COVID-19 pandemic exposed inherent systemic limitations of the clinical trial landscape, it also spurred some positive changes, including new trial designs and a shift toward a more patient-centric and intuitive evidence-generation system. In this Perspective, I share my heuristic vision of the future of clinical trials and evidence-based medicine."

nature.com/articles/s41591-022

Into the "submarine fairyland" – how the scientific artist Else Bostelmann invited the human imagination into the wonder-world of the deep sea at a time when it was more mysterious than the Moon themarginalian.org/2022/01/14/

'At the back of the kitchen, a robot churns out tiny blocks of rice at the rate of about 3,600 an hour. “It’s impossible for a chef to do it that quickly,” said Yurika Murai, from Sushiro’s public relations department. Each block is identical and served up, as tradition demands, at skin temperature.'

theguardian.com/world/2023/jan

@NicoleCRust @gregeganSF
In Larry Niven's "A world out of time" the hero learns new stuff by injecting RNA to help consolidate the memory.
The field is not there yet, but maybe in a couple of decades of studying RNA transport within and between dendrites, axons, neuron-glia etc... we can make it to work.

"We utilise ecDNA amplicon structures to determine precise ecDNA copy numbers and reveal extensive intercellular ecDNA copy number heterogeneity. We further provide direct evidence for the effects of this heterogeneity on gene expression of cargo genes, including MYCN and its downstream targets, and the overall transcriptional state of neuroblastoma cells."

biorxiv.org/content/10.1101/20

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