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#introduction
Hi all, I'm an Assistant Professor at the University of Pittsburgh. My lab studies the #evolution of #bacteria, especially what happens to #pathogens before they get into humans. We particularly love host-microbe interactions involving #microeukaryotes like #amoebae and other #protists.

You can learn more on our lab website teralevinlab.com

I also tend to post nature photos and advice for trainees about navigating science!
#noxp

In response to FL Gov. Ron DeSantis’s actions to limit the teaching of Black history in the state’s public schools, Chicago-based publisher Haymarket Books is offering multiple e-books by progressive Black authors for students to download free of charge. #BlackHistoryMonth #BlackMastodon
truthout.org/articles/haymarke

What happens with Google search, ChatGPT etc is that they skim off the hard word of journalists without linking back to our platforms any more, cutting us off from readers and potential customers who might support our investigations and work, i.e. the very creation of quality information. It‘s value strip-mining at its worst when Google searches don‘t yield links to actual journalism any more but „answers“ that are algorithmically synthesized. niemanlab.org/2023/02/google-n

Nature obit for David Allis

'Histone modifications were first reported by Vincent Allfrey in 1966, but before Allis’s work, their significance and associated enzyme activities remained unclear. Allis showed that they had a direct link with the regulation of DNA’s transcription into RNA and hence into expressed proteins.'

nature.com/articles/d41586-023

I recently wrote a piece about how authors can avoid contributing to medical misinformation. nature.com/articles/s41591-022

This article is a perfect illustration of why I proposed the first principle in the article.

“Be aware of the information landscape into which you are releasing your work. Consider the debates and controversies to which your work might pertain, the special interests that might pick up on your findings and spin them, and the biases that your findings might reinforce.”

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Fibroblasts were traditionally seen as structural cells, but technological advances have revealed important roles in immune function. @arthritisbham @ColesBuckleyLab &co from @KirOxford look at why #fibroblasts matters for health and disease. #PLOSBiology
plos.io/3JI5Cwp

@PLOSBiology Similar to discovering that adipocytes contribute to immune function.
More cell types may be found in the future to participate in the immune system. That is why that system is so amazingly wonderful. (To me, anyway 😏) #immunology

German neanderthals were more into eating elephants (bit.ly/3jGLmk0).
Curious as little has changed in 100k years.
---
RT @NYTScience
In a cave less than 20 miles from Lisbon, a city which has a fair claim to “seafood capital of the world," researchers discovered charred remnants of shells and claws: evidence that Neanderthals were cooking and eating crab 90,000 years ago nyti.ms/3jBwcwD
twitter.com/NYTScience/status/

Maybe you've heard about Trikafta, the 'miracle' drug that has transformed life for people with cystic fibrosis in North America and Europe? It costs $322,000 a year, and patients take it for life.
Turns out the drug isn't available for CF patients anywhere in the developing world. And they say that's on purpose: that the maker, Vertex Pharmaceuticals, is deliberately obstructing access so as to be able to maintain that price tag.

nytimes.com/2023/02/07/health/

📢 Uncover the mysteries of cancer evolution at the Como School on Cancer Evolution #CSCE2023 (23-26 May 2023) and join top researchers from biology & computational sciences for insights on the latest advancements.

#science #sciencemastodon #computationalbiology #biology #cancer #lifesciences #humantechnopole #italy

csce2023.lakecomoschool.org/re

#BRD4-#PRC2 represses #transcription of T-helper 2-specific negative regulators during #Tcell #differentiation:
Brd4 interacts with #Polycomb repressive complex 2 (PRC2) to repress transcriptional expression of T-helper 2 (Th2)-negative regulators #Foxp3 and E3 #ubiqutin #ligase #Fbxw7 during lineage-specific differentiation of #Th2 cells from mouse primary naïve CD4+ T cells
embopress.org/doi/10.15252/emb

FYI

"And while a human fatality is yet to be recorded, the experience of being stung can be excruciating. Keith Payne, a recipient of the Victoria Cross (the nation’s highest military award), has said that being stung by a platypus was worse than being struck by shrapnel."

nybooks.com/articles/2023/02/2

'In this Review, we give an overview of the regulation and cancer relevance of major metabolic pathways in which acetyl-CoA participates. We further discuss recent advances in understanding acetyl-CoA metabolism in normal tissues and tumours and the potential for targeting these pathways therapeutically.'

nature.com/articles/s41568-022

3D Printed models of proteins created from x-ray crystallography data sets. Biologic Models bridge the scientific gap between the digital and physical world. #3DPrint your own protein model at biologicmodels.com/3d-print-re

"The grip of financial self-interest in US health care is becoming a stranglehold, with dangerous and pervasive consequences. No sector of US health care is immune from the immoderate pursuit of profit, neither drug companies, nor insurers, nor hospitals, nor investors, nor physician practices."

HT @gregggonsalves

jamanetwork.com/journals/jama/

"Library warfare hit record highs during the pandemic. The American Library Association logged 729 attempts to censor resources in 2021, targeting 1,597 books, the most since the ALA started tracking requests more than two decades ago. Last year was set to exceed that total, the association says."

ft.com/content/dea4318c-6ecc-4

Martin Lewis died in obscurity in 1962; a retired art teacher who had found some success in his early career, but was largely forgotten.
Lewis spent his last three decades teaching other people how to etch. History chose Edward Hopper, but Martin Lewis was his mentor.

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