"Transient receptor potential vanilloid 1 (TRPV1), a receptor for capsaicin and noxious heat, has been one of the most compelling targets for analgesics. However, systemic inhibition of TRPV1 is an impractical approach as a pain killer, since systemic antagonism induces hyperthermia. Two articles in this issue of the JCI report phenotypes from separate, rare missense mutations of human TRPV1."
A 16th C Japanese medical text explains how diseases were caused by tiny bugs that entered the body and were known as creepy germs or mushi. One of these was known as kosho, an odd, bearded, snake-like, sake-drinking creature whose hat protects it from medicine.
#folklore #JapaneseFolklore #yokai #DailyFolklore #japan
New article! Read The Streptococcus pyogenes vaccine landscape https://www.nature.com/articles/s41541-023-00609-x?utm_source=dlvr.it&utm_medium=mastodon in npj Vaccines
Ordem dos Médicos?
Há três hospitais privados que em 2021 só fizeram partos por cesariana https://www.publico.pt/2023/02/13/sociedade/noticia/ha-tres-hospitais-privados-so-fizeram-partos-cesariana-2021-2038769
#Viral #taxonomy: transforming the existing classification of #viruses into a phylogenetic one is an ongoing challenge. This Consensus View explains how such #taxonomy can encapsulate viral diversity & recognize independent biological origins #PLOSBiology https://plos.io/3xnbLqi
El informe pericial concluye que Pablo Neruda murió envenenado, según la familia https://elpais.com/chile/2023-02-13/la-familia-de-pablo-neruda-asegura-que-el-premio-nobel-murio-envenenado.html?ssm=TW_CC via @el_pais
Which #immune pathways (beyond #TLRs) control #otitis media and #COPD-inducing #Moraxella catarrhalis #infection?
Si-Ming Man and colleagues from Australian National University reveal requirement for #guanylate-binding GBP proteins and #caspase11-#NLRP3 #inflammasomes
In our #MidweekMovie we look at germband extension in Drosophila embryos.
In their @Dev_journal paper, Lenin Chandran, @luschnig , H.-Arno Müller and colleagues find that Src42A is required for E-cadherin dynamics during axis elongation.
https://doi.org/10.1242/dev.201119
#WhiteLightWednesday #devbio #microscopy
I'm guessing Atwood's wallet is the one that says bad mother***er on it:
"To those who seek to stop young people from reading The Handmaid’s Tale: Good luck with that. It’ll only make them want to read it more."
At the start of the 2020 global #pandemic, Biologic Models participated with a team of international research scientists examining the structural proteins of 2019 novel #Coronavirus. Created from that research is this #3Dprint of #SARSCoV2 Virion. https://biologicmodels.com/viruses/sars-cov-2-virion/ @mstdn.science
** Global Symposium 7 is tomorrow! **
Beyond the SNP: Structural Variants and Repetitive DNA in Genomics and Evolution
Access instructions were emailed to all registered members yesterday.
See you on Gathertown!
@SMBEmeetings
'Saura reunió una obra fotográfica con miles de negativos que quizás sea ahora buena ocasión para mostrar una completa relectura. Autodidacto, con solo 19 años expuso las fotos tomadas con una Rolleiflex en la Real Sociedad Fotográfica de Madrid.'
https://elpais.com/cultura/2023-02-14/la-piel-de-fotografo-de-carlos-saura.html
Sagy et al. have recently published in #NatureMedicine an analysis of the real-world efficacy of #JYNNEOS, the #smallpox shot redeployed against #monkeypox.
https://www.nature.com/articles/s41591-023-02229-3
Last Fall I wrote a column for Nature Medicine that touched on the FDA's Animal Rule, used in the approval of anti-smallpox drugs due to the difficulty in designing ethically acceptable efficacy screens.
"The IBRO Parenthood Grant aims to support early-career Principal Investigators who are approaching parental leave (either via birth or adoption) by providing supplemental laboratory funding."
C'est désormais confirmé. Avec une analyse de plusieurs centaines de milliers de tweets, des chercheurs confirment que des antivax/complotistes répandent des discours climatosceptiques depuis plusieurs mois.
Explication dans cet article, à partager un maximum svp !
https://bonpote.com/comment-les-antivax-complotistes-sont-devenus-climatosceptiques/
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com