Thiago Carvalho @cyrilpedia@social.cleverlibre.org

@v4169sgr I really liked the Sleepwalkers - though I have not read in at least 20 years, and I don't know how well it holds (not as writing, but as science history, because Koestler's views in other fields, like biology, really don't hold up well at all).

"Orwell sat and waited, and waited, for Camus to arrive. He never turned up: he was laid up with an exacerbation of tuberculosis. They would never get the chance to meet again, and Orwell would die five years later, having lost his own battle with the same disease"

https://thecritic.co.uk/orwell-camus-and-truth/

Wait, isn't that like a mission to learn the downhill skiing secrets of Rio de Janeiro???

"For the past five months, I’ve been on a mission to dial-in a home cook-friendly recipe for a thin-crust pizza popular in the Midwest, Chicago in particular."

https://www.nytimes.com/2023/03/17/dining/tavern-thin-crust-pizza-chicago.html

*Pause*

https://www.youtube.com/watch?v=rLtZKkCIVmI

'Let me start by laying my cards on the table. I’m the son of a missionary. My father’s parents were atheists and scientists. He, in adolescent rebellion, became a Christian; I, ditto, became an atheist.'

https://www.spectator.co.uk/article/the-age-old-debate-continues-are-science-and-religion-compatible/

@Rahimilab Time to make some coffee, sit by the fire & reread the works of Wayne Potts & Edward Wakeland :)

@Rahimilab I suspect some of this may just be a bias of the time of data collection, as the general state of the T and B compartments are going to reflect the experience of a lifetime. A really interesting aspect here is the sibling relationship angle - it would be interesting to try to integrate this with what we know about assortative mating patterns & MHC.

"The World Health Organization rebuked Chinese officials on Friday for withholding research that may link Covid’s origin to wild animals, asking why the data had not been made available three years ago and why it is now missing."

https://www.nytimes.com/2023/03/17/health/covid-origins-who.html?smid=nytcore-ios-share&referringSource=articleShare

A good reference to have if you're working with nude mice:

"Here we present the genome assemblies for the NOD/SCID and BALB/c nude strains to overcome this short-coming for the future and improve our understanding of these models in the process."
#Preprint #Immunology

https://www.biorxiv.org/content/10.1101/2023.03.16.532783v1?med=mas

Based on data collected in Uganda between 2003 and 2018.

"This study suggests that male-targeted HIV programs to increase HIV suppression are critical to reduce incidence in women, close gender gaps in infection burden and improve men's health in Africa."

#Preprint #publichealth #hiv

https://www.medrxiv.org/content/10.1101/2023.03.16.23287351v1

"Over and over, trials evaluating PD-1/PD-L1 inhibitors in advanced prostate cancer have missed the mark. The failures have led to questions as to why—and have prompted oncologists to conclude that new treatment strategies are needed."

#Immunology #immunotherapy #checkpointinhibitors #prostatecancer

https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-NB2023-0017/718790/PD-1-Blockade-Falls-Short-Repeatedly-in-Prostate