Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
'The Biden administration on Friday finalized new rules meant to cut down on widespread overbilling by private Medicare Advantage insurance plans, but softened the approach after intense lobbying by the industry.'
Thiago Carvalho
boosted
Good article. AI has much to offer humanity. It could also wreak terrible harm. It must be controlled https://www.theguardian.com/commentisfree/2023/apr/02/ai-much-to-offer-humanity-could-wreak-terrible-harm-must-be-controlled?CMP=Share_iOSApp_Other #ai
Thiago Carvalho
boosted
Novo Nordisk
Revealed: maker of Wegovy ‘skinny jab’ is funding NHS weight-loss services https://www.theguardian.com/business/2023/apr/02/revealed-maker-of-wegovy-skinny-jab-is-funding-nhs-weight-loss-services?CMP=share_btn_tw
"The ruling took effect immediately and applies nationwide. It affects dozens of potentially lifesaving preventive health care services that the federal government recommends, including drugs that prevent H.I.V. transmission and screenings for adolescent depression."
Thiago Carvalho
boosted
"Theoretical studies predict that, under stationary environmental variation, the level of plasticity should evolve to match the predictability of selection at the timing of development. However, the extent to which patterns of evolution of plasticity for more integrated traits are mirrored by their underlying molecular mechanisms remains unclear, especially in response to well-characterized selective pressures exerted by environmental predictability."
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001895
Thiago Carvalho
boosted
Antisense oligos & n=1 cases:
“A lot of clinicians might have a patient with a rare disease and want to help, but don’t have any idea how to approach the FDA. Where do you find a source of oligonucleotide for under $500,000? For a single patient?”
"After peripheral nerve injury, there is an increase in the population of macrophages in the sensory ganglia which have been involved in different conditions, especially in neuropathic pain development and nerve regeneration. However, it is still under debate whether macrophages accumulation in the sensor ganglia after peripheral nerve injury is due to the local proliferation of resident macrophages or as a result of blood monocytes infiltration."
https://www.biorxiv.org/content/10.1101/2022.03.22.485276v1#review
'Here, we developed a memory-guided behavioral task that mice perform reliably in the head-fixed setting for months, and performed anatomical tracing, neural dynamic recordings, and optogenetic perturbations to characterize the role of these intervening circuits in memory consolidation.'
https://www.sciencedirect.com/science/article/pii/S0092867423001678?dgcid=coauthor
Thiago Carvalho
boosted
I would prefer to see the IGC rebooted as an independent research institute (they are rare in Portugal). But if the Gulbenkian is hellbent on having it annexed by an existing public university, the ITQB-NOVA is a much better fit. I ran the PhD program at IGC for a few years, we could not have done it without ITQB as the academic partner. There is also a complementarity in themes, the ITQB provides expertise in structural biology and biochemistry that the IGC does not have (the wonderful, generous and deeply missed Alekos Athanasiadis was the only real IGC resource for this).
Thiago Carvalho
boosted
Interesting work in mice on checkpoint inhibitors and bacterial translocation.
"They observed translocation of some bacterial species during ICT enhanced dendritic cell activation and lymph node remodeling. These enhanced responses promoted antitumor T cell responses in tumor -raining lymph nodes and subcutaneous tumors."
Thiago Carvalho
boosted
None of Marsh’s books are for the faint of heart. In his prior books, he openly acknowledges his mistakes that caused harm to patients. As a patient himself now at old age, he witnesses the impassive cruelty of the medical system, and ponders on unresolved tensions between doctors, the medical system and society at large.
@NicoleCRust I'm not sure if I'd call it a patient memoir, but Tony Judt's "The Memory Chalet" is a stunning book.
Thiago Carvalho
boosted
Best patient memoirs?
In the context of writing a book about brain/mind research, I want to understand more about how the disorders I am writing about impact individuals. For this, I'm (in part) turning to patient memoirs. Any recommendations?
Here are a two I'm reading:
Depression:
https://en.wikipedia.org/wiki/Darkness_Visible_(memoir)
Schizophrenia:
https://www.graywolfpress.org/books/collected-schizophrenias
Thiago Carvalho
boosted
RT @xriskology
Holy hell, this is an absolutely incredible statement from the Lemkin Institute (@LemkinInstitute).
"Lemkin" refers to "Raphael Lemkin," the individual who coined the word "genocide." (Continued below.)
Thiago Carvalho
boosted
Self-inflicted DNA breaks in cell differentiation and cancer https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(23)00043-0?rss=yes&utm_source=dlvr.it&utm_medium=mastodon
We hold this truth to be self-evident:
"I think there are already a lot of individual PIs who see preprint peer review as a good thing and organise preprint clubs with their students. They see it as valuable training for students who are going to become scientists, but also for students who are not going to become scientists. But this is not necessarily true for all PIs. So my view is that the institutions ought to do more to make it part of their training programs."
https://prelights.biologists.com/news/prelights-talks-to-richard-sever/
Looking back on a BBC classic
"At some point during my PhD, I started thinking about science journalism and publishing and my supervisor encouraged me to explore these areas. Basically, I had to figure out whether I wanted to be a journalist or an editor. So when I finished my PhD, I wrote to tons of journalists."
@richardsever
https://prelights.biologists.com/news/prelights-talks-to-richard-sever/
"But then… as he reaches the end of his analysis, Muller offers a stunning prediction. In essence he says that if you want to really understand the structure of the gene, it will not be done with Drosophila. Instead, he recommends the study of “d’Herelle bodies.” In 1917, the French physician Félix d’Hérelle discovered bacteriophage."
Models and their quirks:
"Here Muller was exceptionally lucky, because the somatic pairing of homologous chromosomes along their entire length—readily seen in #Drosophila—is not a general feature of eukaryotes."
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
