Thiago Carvalho @cyrilpedia@social.cleverlibre.org

The Max Planck Institute for Biology of Ageing in Cologne is recruiting a junior PI
#ScienceJobs

https://recruitingapp-2695.de.umantis.com/Vacancies/447/Description/1

CART cells beyond cancer - my latest Clinical Pipeline column for Nature Medicine is out. CAR T cell technology in humans was first tried for HIV in the 90s. Now veteran HIV researchers are giving them another shot.

#immunotherapy #publichealth #hiv #Immunology #cartcells
#ScienceCommunication #SciComm #InfectiousDisease

https://www.nature.com/articles/d41591-023-00042-6

For a lot of my acquaintances that work/are considering working for the FDA, telework has indeed been a significant factor (even pre-pandemic).

"Telework helps FDA compete for scientists. What if it’s taken away?"
https://www.statnews.com/2023/05/11/fda-telework/

Global sea level rise and its accelerating rate... 🌊

First update now in for 2023 from https://sealevel.colorado.edu.

"A panel of advisers to the Food and Drug Administration voted unanimously on Wednesday that the benefits of making a birth control pill available without a prescription outweigh the risks, a significant step in the decades-long push to make oral contraception obtainable over the counter in the United States."

https://www.nytimes.com/2023/05/10/health/fda-otc-birth-control-pill.html

'They observed the significant induction of IFNβ and other inducible chemokines in the medium of primary microglia treated with tau fibrils, which was abrogated by the genetic ablation of Cgas. This raised a question: how does tau protein activate this DNA sensor? Through a series of clever in vitro experiments, the authors demonstrated that tau fibrils localize to microglial lysosomes and mitochondria and that they promote the release of mitochondrial DNA (mtDNA) to the cytosol'

https://www.nature.com/articles/s41590-023-01485-2

How are specific dysfunctional #mitochondria removed under steady-state conditions?

Julia Pagan and coworkers (University of Queensland) show that an #SCF #ubiquitin #ligase based on #FBXL4, mutated in #MTDPS13, limits basal #mitophagy via #ubiquitination of #NIX and #BNIP3 receptors

https://www.embopress.org/doi/10.15252/embj.2022112767

'For seventy percent of us with ME/CFS, the illness that tore our lives apart started with a viral infection. We knew, when Covid-19 struck, that we would soon be hearing about a chronic, debilitating post-Covid syndrome devastating the lives of an entirely new influx of people.'

https://lithub.com/how-chaos-theory-can-revitalize-and-save-modern-medicine/

'Prime minister Rishi Sunak is at pains to insist that “the police are operationally independent of government”, which might be a little too convenient. I’m not sure you get to pass draconian new legislation into law a mere three days before the coronation, then claim its prompt misuse has nothing to do with you.'

https://www.theguardian.com/commentisfree/2023/may/09/met-police-royal-protesters-cells-force?CMP=share_btn_tw

#IDMastodon #Viralimmunology @thelancet #SarsCoV2 RNA widely distributed in 84 distinct anatomical locations up to 230 days after infection . the viral load #COVID19 might be low but still detectable in biospecimens with the appropriate assays following acute #SarsCoV2 infection and Viral persistent is possible pathogenesis of #LongCovid
📌 https://www.thelancet.com/journals/lanres/article/PIIS2213-2600%2823%2900142-X/fulltext
📌 https://www.eurekalert.org/news-releases/950412

#DrugDiscovery #Drugdevelopment #viralimmunology @Nature summarize the most recently developed broad-spectrum fusion inhibitors (neutralizing antibodies, peptides, proteins, small-molecule compounds) & candidate #vaccines targeting the conserved elements in #SARSCoV2 S2 subunit
📌 https://www.nature.com/articles/s41392-023-01472-x
📌 https://www.nature.com/sigtrans/

Two important, groundbreaking studies on pancreatic cance this week. I reviewed them here https://erictopol.substack.com/p/a-one-two-punch-against-pancreatic

unearned prestige https://sometimesimwrong.typepad.com/wrong/2023/05/unearned-prestige.html

Make sure to read until the end. Final paragraph is the most important one: "more radical thing ... to make science more transparent and equitable is to take back control of how we allocate prestige. we don't need to wait for journals to reform themselves ... there's no reason to think journals will ever do that - most of them are in business of chasing impact and profits, so why would we expect them to change? it's time to move on."

@siminevazire