Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
@miguelgf I think that proposal is ready for submission!
In which @madparreira made a fully wearable dress out of paper - and then printed it!
Thiago Carvalho
boosted
Don't be the infamous Reviewer 2!
Instead, give your colleagues helpful feedback on the manuscript and contribute to making a positive change in #science!
👇
Write #preprint reviews following FAST principles https://osf.io/9wdcq/
Post the reviews as citable objects using a service such as @prereview, Qeios, or
@science_open.
Your #preprint review may be a review requested by a journal editor (👉https://asapbio.org/publishyourreviews ) or those you decide to write independently.
Another entry in our 'not all good wines are Portuguese' series, courtesy of my gracious host in Nice, @miguelgf
Thiago Carvalho
boosted
Annals of Internal Medicine: Masks should continue to be worn in healthcare settings.
#COVID #BringBackMasks https://www.acpjournals.org/doi/10.7326/M23-1190
"To enable detection of which cells upregulate MHC pathways in vivo, we generated two novel MHC I and MHC II reporter mouse lines that express tdTomato when these pathways are activated, and used these lines to define their incidence and transcriptional characteristics in two mouse models of inflammatory demyelination."
#Neuroimmunology
Thiago Carvalho
boosted
How do veiled chameleons make their left and right sides? What is it like working with veiled chameleons?
Read the #behindthepaper story from Dr. Natalia (Natasha) Shylo, Dr. Paul Trainor and colleagues at Stowers Institute for Medical Research:
Tools
"Using adenoviral and transgenic approaches to label neurons, we show robust protein biotinylation in neuronal soma and axons throughout the brain, allowing quantitation of over 2000 neuron-derived proteins spanning synaptic proteins, transporters, ion channels and disease-relevant druggable targets."
Thiago Carvalho
boosted
Study from Dana Pe'er and Scott Lowe's labs. Direna Alonso and Cassandra Burdziak show how genetic and environmental events interact to drive tumorigenesis in #PDAC #cancer
Now published: doi.org/10.1126/science.add5327
Lot's of computational innovation in there as well: Quantifying cellular plasticity, a module view on cell cell communication etc.
It was awesome to be part of the team!
Thiago Carvalho
boosted
'Poland, historically staunchly Catholic, has slowly been coming to terms with the scale of historical sexual abuse in the church, but until recently the figure of John Paul II, whom many Poles revere for his role in the ending of communist rule in the country, has remained untouchable.'
Thiago Carvalho
boosted
A famous #Polycomb protein with roles in gene silencing but also activation!
BMI1 fine-tunes gene repression and activation to safeguard undifferentiated spermatogonia fate
Front. Cell Dev. Biol., Volume 11 - 2023
'Because semiautomatic weapons are illegal in Serbia, the state was able to respond quickly. The authorities did make some early blunders. Education Minister Branko Ružić traced the causes of the shootings to “video games” and “so-called Western values,” and was compelled to resign within four days. Police requested that schools in Kikinda and Užice deliver lists of “problematic and asocial” children (a request the schools rightly refused). But it took only a day for President Aleksander Vučić to deliver a speech promising swift action to protect public safety and to reduce ownership of illegal firearms by 90 percent.'
'In this trial involving children 1 to 3 years of age with peanut allergy, epicutaneous immunotherapy for 12 months was superior to placebo in desensitizing children to peanuts and increasing the peanut dose that triggered allergic symptoms.'
https://www.nejm.org/doi/full/10.1056/NEJMoa2212895?query=featured_home
'Oxford university ended its relationship with the Sacklers on Monday after a Financial Times investigation into its continued ties with the wealthy family led academics and students to call for sweeping reforms.'
https://www.ft.com/content/28ea87bb-f873-4693-a767-5dc79c5b3b92
'The task force acknowledged that dense breasts can increase a woman’s risk of breast cancer and that certain race or ethnicity groups are at higher risk for early-onset breast cancer. But it failed to issue more individualized recommendations for these groups, instead calling only for more research. Black women under 50, for example, die of breast cancer at twice the rate of white women under 50 in the United States. We have known this for decades, and it is unacceptable.'
#BreastCancer
https://www.nytimes.com/2023/05/16/opinion/breast-cancer-screening.html
Thiago Carvalho
boosted
Last chance to register for the ICOR webinar where you can learn about updates on collaborative open research initiatives:
✳️an update from the eLife on their new publishing model,
✳️a report on the Gates Foundation study on fair and equitable pricing for publishing,
✳️an overview from the Pew Charitable Trusts' Evidence Project,
& more
Join ICOR tomorrow 10:30am – 12pm ET
https://us02web.zoom.us/meeting/register/tZItcO2qrj4oEtfk_CFus4rYIqX0awNwh0pk#/registration
Thiago Carvalho
boosted
EXO1 to the rescue: How does #EXO1 save #BRCA1-deficient cells?
The team of Profs. H. van Attikum & S.M. Noordermeer shows that BRCA1-deficient cells are unable to overcome damage if EXO1 is deleted. #preprint
#preLight by Jennifer Ann Black: https://prelights.biologists.com/highlights/exo1-mediated-dna-repair-by-single-strand-annealing-is-essential-for-brca1-deficient-cells/
Thiago Carvalho
boosted
"A monolithic group of scientists will bring many of the same preconceived notions to their work. But a group of many backgrounds will bring different points of view that decrease the chance that one prevailing set of views will bias the outcome. This means that scientific consensus can be reached faster and with greater reliability. It also means that the applications and implications will be more just for all. How is this a threat to scientific rigor and the merit of discoveries?"
https://www.science.org/content/blog-post/it-matters-who-does-science#.ZF4ty3LYhwN.twitter
Thiago Carvalho
boosted
'These results indicate that NRF2 regulates cardiac metabolic reprogramming by stimulating the diversion of glucose into the PPP, thereby providing cardiac protection during stress by generating NADPH and providing nucleotides to prevent stress-induced DNA damage.'
#Preprint
https://www.biorxiv.org/content/10.1101/2023.05.12.540342v1?med=mas
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
