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"In the history of modern physics, there has never been a widely accepted theory in which a moving, directional sense of time is fundamental. Many of our most basic descriptions of nature – from the laws of movement to the properties of molecules and matter – seem to exist in a universe where time doesn’t really pass. However, recent research across a variety of fields suggests that the movement of time might be more important than most physicists had once assumed."

aeon.co/essays/time-is-not-an-

May 21, 1799, #birthday of Mary #Anning. Carpenter daughter, she founded a fossil business in Lyme Regis, Dorset, making important discoveries like complete skeletons of Ichthyosaurus & Plesiosaurus 🪨 🔨🐉

bbc.co.uk/programmes/w3csxh9j?

'But muddling through bad ideas is a necessary step in the creative process. The first solutions that come to mind tend to be either preexisting ideas or popular wisdom. These are the paths of least resistance. Though avoiding them requires some work, it’s the surest way to find original ideas that elude our default assumptions and strategies. Instead of interpreting difficulty as a sign of failure, we should see it as a harbinger of solutions.'

theatlantic.com/ideas/archive/

More good news on .

"The would be the first to protect babies from respiratory syncytial virus, or R.S.V., which is the reason many infants are admitted to children’s hospitals each year and kills several hundred under 5 each year."

nytimes.com/2023/05/18/health/

The germans have a word for it.

"This week I went to Germany where I discovered they have a word for being excessively fond of abbreviations. The word is abkürzungsfimmel and it makes sense in a language with words of such dire length that they look as if they’ve been typed on a keyboard with no space bar."

ft.com/content/29c662fd-339d-4

Now that I've read the credits, I want to go back and pay more attention to Mr Lawrence's performance.

#JamelleBouie gets it: “The denial of dignity to one segment of the political community…threatens the dignity of all. This was true for [Frederick] Douglass and his time…and it is true for us and ours as well. To deny equal respect and dignity to any part of the citizenry is to place the entire country on the road to tiered citizenship and limited rights, to liberty for some and hierarchy for the rest.”

nytimes.com/2023/02/10/opinion

The privatisation of #water firms has had a clear result:

1. to fund profits to #shareholders, investment was constrained;

2. low investment has led to the #watercrisis, #pollution & water losses through leaks;

3, (Finally) under-funding is to be rectified & funded via loans;

4. the ongoing costs of loans will be repaid by customers through higher bills.

The only thing the #investors have done is stolen our money, offering no actual benefits;

the #Tories' #kleptocapitalism in a nutshell!

A Florida woman was denied an abortion for her fetus with Potter syndrome which meant no survival outside the womb. She had to carry until 37 weeks & then go through labor, delivery, baby's death, funeral. ‘The law has created torture.’
washingtonpost.com/health/inte

More good news on .

"The would be the first to protect babies from respiratory syncytial virus, or R.S.V., which is the reason many infants are admitted to children’s hospitals each year and kills several hundred under 5 each year."

nytimes.com/2023/05/18/health/

'Pot1 is a subunit of telomere capping complex that binds to the G-rich overhang and inhibits the activation of DNA damage checkpoints. In this study, we explore new functions of fission yeast Pot1 by using a pot1-1 temperature sensitive mutant'
@miguelgf et al

biorxiv.org/content/10.1101/20

The district morons apparently have put together a great reading list:

"The district, which encompasses the city of Pensacola in Florida’s west and borders Alabama, withdrew a series of books including works by Penguin authors Toni Morrison, Kurt Vonnegut and Khaled Hosseini."

ft.com/content/dde3cc89-3463-4

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" In this study, we used a CRISPR nuclease that targets a site within an exon of an essential gene and designed a cargo template so that correct knock-in would retain essential gene function while also integrating the transgene(s) of interest. Cells with non-productive insertions and deletions would undergo negative selection. This technology, called SLEEK (SeLection by Essential-gene Exon Knock-in), achieved knock-in efficiencies of more than 90% in clinically relevant cell types without impacting long-term viability or expansion."

nature.com/articles/s41587-023

The germans have a word for it.

"This week I went to Germany where I discovered they have a word for being excessively fond of abbreviations. The word is abkürzungsfimmel and it makes sense in a language with words of such dire length that they look as if they’ve been typed on a keyboard with no space bar."

ft.com/content/29c662fd-339d-4

Tools

" In this study, we used a CRISPR nuclease that targets a site within an exon of an essential gene and designed a cargo template so that correct knock-in would retain essential gene function while also integrating the transgene(s) of interest. Cells with non-productive insertions and deletions would undergo negative selection. This technology, called SLEEK (SeLection by Essential-gene Exon Knock-in), achieved knock-in efficiencies of more than 90% in clinically relevant cell types without impacting long-term viability or expansion."

nature.com/articles/s41587-023

Going out to get me some Penguins today:

"Penguin Random House is suing a Florida school district for banning several of its books, in the latest pushback by companies and organisations against “anti-woke” actions by US political conservative"

ft.com/content/dde3cc89-3463-4

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