Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
Oh no! Look at all these Old Montréal businesses not generating any profit because of the streets being closed for cars. Utterly devastating move by the city to prevent people from accessing these businesses by having nowhere to park. How dare they doom the economy like this?
'Here, we show that yeast paralogous genes are more divergent in transcription than in translation. We explore two causal mechanisms for this predominance of transcriptional divergence: an evolutionary trade-off between the precision and economy of gene expression and a larger mutational target size for transcription.'
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010756
"Hundreds of thousands of low-income Americans have lost Medicaid coverage in recent weeks as part of a sprawling unwinding of a pandemic-era policy that prohibited states from removing people from the program."
Thiago Carvalho
boosted
Humans!
Please don't send us any more unsolicited nude pics with instructions on how to get to your house.
It's creepy.
Sincerely,
The Aliens.
Thiago Carvalho
boosted
Our experience with Elife was good but not 100%. https://elifesciences.org/reviewed-preprints/87301 IMO the reviews were fair but put little weight on the perturbational studies that support the detected correlations. I wish there was one back and forth btwn editors and authors before posting the reviews.
"The European Commission and Pfizer have agreed a deal to cut the number of Covid-19 vaccines supplied to the EU, resolving tensions between the majority of member states over paying for shots that may not be used."
https://www.ft.com/content/eb4fe823-66bd-4e1a-8b96-13b8f8c3dce9
Thiago Carvalho
boosted
“Two new studies illuminate the mechanisms for inflammation of brain tissue which is persistent and occurs even in patients with a mild #Covid19 illness. Importantly, these were studies of people with Covid, not specifically individuals who were suffering from Long Covid.”
A new post from @erictopol.
'In physics education research studies I led as a postdoc, I learned that many scientists—particularly those from underrepresented groups—find public engagement helps sustain them through tough times in their careers, just as it did for me. One student shared with me that facilitating the children’s hospital project inspired her to persist in physics; being recognized as an expert by the public helped her overcome a sense that she didn’t belong in academia. I had felt the same.'
Thiago Carvalho
boosted
Immunologist Akiko Iwasaki: ‘We are not done with Covid, not even close’
27 May 2023
'Researchers who analysed the biomedicine training pathway found that the greatest loss of people from under-represented minorities seems to occur at two points: during undergraduate education, and in the transition from postdoctoral fellowship to tenure-track faculty position'
Thiago Carvalho
boosted
A useful new #OpenScience resource for #immunology
"We would like to highlight a new community resource: the Immunological Proteome Resource (ImmPRes; http://immpres.co.uk/). ImmPRes aims to provide an in-depth high-quality map of the immune cell proteomes."
Yes, but we need more
"There are good examples in Europe of scientific breakthroughs being made in institutions where long-term financial commitment allows outstanding scientists to tackle fundamental questions."
Thiago Carvalho
boosted
Wolf lamp, could be Roman, but is by @hunchbacksociety
#ceramics #stoneware #handmade #artgallery #ceramic #artmastodon
https://madalenaparreira.com/Hunchbacksociety
Thiago Carvalho
boosted
'We do seem to be at the stage of human intellectual decay where anyone who is a multibillionaire is also automatically described as a “philanthropist”, when in many cases “misanthropist” would be more supported by the evidence.'
https://www.theguardian.com/commentisfree/2023/may/26/jeff-bezos-money-lauren-sanchez-europe
A useful new #OpenScience resource for #immunology
"We would like to highlight a new community resource: the Immunological Proteome Resource (ImmPRes; http://immpres.co.uk/). ImmPRes aims to provide an in-depth high-quality map of the immune cell proteomes."
Thiago Carvalho
boosted
Cholesterol & anti tumor T cell immunity:
"We analyze the cholesterol atlas in the tumor microenvironment and find that intratumoral T cells have cholesterol deficiency, while immunosuppressive myeloid cells and tumor cells display cholesterol abundance. Low cholesterol levels inhibit T cell proliferation and cause autophagy-mediated apoptosis, particularly for cytotoxic T cells"
#Immunology #immunotherapy #immunooncology #CancerImmunity
https://www.sciencedirect.com/science/article/abs/pii/S1535610823001423?via%3Dihub
Thiago Carvalho
boosted
'We are starting a clinical trial where 50 patients will be treated with the antiviral drug Paxlovid and 50 will be given a placebo. This is to probe whether persistent virus infection may be causing long Covid in a subset of people. We’re not giving them the conventional five-day course, but a 15-day course of treatment, to see if that can eliminate the source of the problem, which is the remnants of replicating virus'
Thiago Carvalho
boosted
Pathogenic forms of the ANT1 protein lead to harmful consequences in yeast and mice by clogging the channels that allow mitochondria to import proteins. https://elifesciences.org/digests/84330/a-novel-way-to-cause-disease?utm_source=mastodon&utm_medium=social&utm_campaign=organic
"In this study, we revisit and significantly extend the initiator-titration model, proposed thirty years ago, and explain how bacteria precisely and robustly control replication initiation based on the mechanism of protein copy-number sensing."
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
