Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
A Phase II Randomized Study of Zanubrutinib (oral btk-inhibitor) Plus Obinutuzumab (cd20-directed antibody)
Versus
Obinutuzumab Monotherapy in Patients With Relapsed or Refractory Follicular #Lymphoma
https://pubmed.ncbi.nlm.nih.gov/37506346/
217 patients randomized. Surprising to me. Seems worth a close reading of the full report.
#MEDMASTODON #Cancer
#ClinicalResearch #Oncology #Medicine #lymsm @majorajay
Thiago Carvalho
boosted
”The directive to present the optimistic range estimates came from Tesla Chief Executive Elon Musk…” https://www.cnbc.com/2023/07/27/tesla-created-secret-team-to-suppress-thousands-of-driving-range-complaints.html #musk #tesla
"South America has suffered one of the warmest January-to-July periods on record. Chile has been among the worst affected countries with fires at the beginning of the year and now extended droughts. Cordero said Santiago was sweltering in its ninth heatwave since January and was expected to break the annual record of 10 heatwaves, set in 2020."
"A worker sleeps on a cart full of chickens at a wholesale poultry market in Mumbai, August 2010. Photograph: Danish Siddiqui/Reuters”
"We evaluated the risk of death, cancer, and autoimmune disease among adult patients who had undergone thymectomy as compared with demographically matched controls who had undergone similar cardiothoracic surgery without thymectomy. T-cell production and plasma cytokine levels were also compared in a subgroup of patients."
#Immunology #Thymus
https://www.nejm.org/doi/full/10.1056/NEJMoa2302892?query=featured_home
Thiago Carvalho
boosted
'I love libraries because time and again, they have been my literal lifeline. As an abused child and as a financially insecure adult, library access to books has often kept me this side of suicidal levels of despair. The thought of anything threatening public libraries makes me ready to fight someone with my actual teeth.'
https://karawynn.substack.com/p/the-coming-enshittification-of-public-libraries
Thiago Carvalho
boosted
"Patients with Crohn’s disease have increased levels of anti-S. cerevisiae antibodies (which detect mannan, a common component of the fungal cell wall. Measurement of these antibodies can be used to distinguish between Crohn’s disease & ulcerative colitis"
#Immunology #MucosalImmunology
https://www.nature.com/articles/s41575-023-00816-w?utm_source=dlvr.it&utm_medium=twitter
Thiago Carvalho
boosted
Closing libraries is how you burn books without lighting a match.
Thiago Carvalho
boosted
Thiago Carvalho
boosted
There's something delicious about a brilliant, Nobel-prize-winning scientist being wrong.
I'm reading Richard Feynman's (throroughly enjoyable) "Six Easy Pieces" (https://amzn.to/45ie510). In a fine bit of epistemic trespassing, he decides to sum up biology. This is how he starts...
'For example, loss of function of the microglial gene Trem2 renders microglia dysfunctional and causes an early-onset neurodegenerative syndrome, and Trem2 variants are among the strongest genetic risk factors for AD. Thus, restoring microglial function represents a rational therapeutic approach. Here, we show that systemic hematopoietic cell transplantation followed by enhancement of microglia replacement restores microglial function in a Trem2 mutant mouse model of AD.'
#Alzheimer #NeurodegenerativeDisease #Microglia #Neuroimmunology
https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(23)00251-5#%20
Thiago Carvalho
boosted
Tricky Dick strikes again:
'Nixon’s advisers reportedly coined the phrase “pulling a Nixon” for the oenophile president’s predilection for pouring official guests vin ordinaire while surreptitiously drinking First Growth Claret.’
https://www.ft.com/content/b31ce09e-6909-4600-a87e-7942a84b1439
Thiago Carvalho
boosted
The dangers posed by nuclear weapons are great and growing.
Editors of health journals call on health professionals to support efforts to eliminate nuclear weapons
https://www.bmj.com/content/382/bmj.p1682 @kamranabbasi @parveenazamali @mja_editor @kbibbinsdomingo @ippnw
Thiago Carvalho
boosted
Very interesting thoughts happening: "In vivo hematopoietic stem cell modification by mRNA delivery"
https://www.science.org/doi/10.1126/science.ade6967
Thiago Carvalho
boosted
“Mosquitoes are evolving as humans have pushed them to adapt. Climate change is adding to the health crisis in India.”
@aliyabashir reports on how climate change is changing dengue fever
https://www.bmj.com/content/382/bmj.p1690
Thiago Carvalho
boosted
Evaluation of protein extraction methods to improve meta‐proteomics analysis of treated wastewater biofilms | https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/pmic.202300191?af=R #proteomics
Thiago Carvalho
boosted
Postdoctoral fellow in the experimental and/or computational study
Cold Spring Harbor Laboratory
See the full job description on jobRxiv: https://jobrxiv.org/job/cold-spring-harbor-laboratory-27778-postdoctoral-fellow-in-the-experimental-and-or-computational-study/?feed_id=53855
#ScienceJobs #hiring #research
Cold Spring Harbor, NY, USA #UnitedS...
https://jobrxiv.org/job/cold-spring-harbor-laboratory-27778-postdoctoral-fellow-in-the-experimental-and-or-computational-study/?feed_id=53855
Thiago Carvalho
boosted
I will die on this hill:
We will not fix our democracy until we start doing criminal prosecutions of the wealthy again. Not just weakly using DPAs and fines
and prosecutions of corporations.
Musk and the hospital execs in the news today must face threats of *jail*.
No fine will ever break a billionaire— they just pay out some funds and move on. But criminal charges can take down their lifestyle and hold them truly accountable.
#musk #doj #trump #indictment
Thiago Carvalho
boosted
The rank corruption of Clarence Thomas continues to be exposed, one sleazy item at a time.
How are we learning about this? Not from law enforcement or others who have subpoena power (e.g. Congress), but by journalists.
Latest example, from the NY Times. https://www.nytimes.com/2023/08/05/us/clarence-thomas-rv-anthony-welters.html?action=click&module=Well&pgtype=Homepage§ion=US%20News
Thiago Carvalho
boosted
Public health in action! Though it shouldn't need to be if the water was clean enough!
#Ecoli #sewage #water #triathlon #diarrhoea #diarrhea #ukpolitics #publichealth #microbiology #infectiousdiseases #medicine
Investigation after 57 swimmers fall sick and get diarrhoea at Sunderland world triathlon championship race
> Athletes competing on stretch of UK coastline where reduced water quality at centre of dispute over sewage discharges
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
