Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
Subset of neurons in #hypothalamus increases appetite & decreases #thermogenesis. @JongSohn &co show that ion channel GIRK2 functions in hypothalamic NPY/AgRP neurons to increase energy expenditure in mice and may control body weight @kaistpr #PLOSBiology https://plos.io/3qGa8Ev
Thiago Carvalho
boosted
Just published
When a nasal vaccine provides superior immune response compared with a shot (2 doses of each). Results from a randomized clinical trial, including vs Omicron, and with less local and systemic adverse effects
https://nature.com/articles/s41541-023-00717-8
Thiago Carvalho
boosted
Reading:
Viome, a microbiome startup, raises $86.5M, inks distribution deal with CVS https://tcrn.ch/47zUkDY
Which quotes me a bit. Needless to say, I am very skeptical of Viome and many of its claims.
Thiago Carvalho
boosted
#EMT is an early event in cell dissemination from epithelial tissues. @EricTheveneau &co show that in frog embryos the #metalloproteinase MMP28 is produced by placodes & acts inside the nucleus of neighboring neural crest cells to trigger EMT #PLOSBiology https://plos.io/3snRL7F
Thiago Carvalho
boosted
He's going to get people killed with this.
You know what Nazis used to do in my Twitter replies before I started mass blocking?
They'd give my home address out to OTHER Nazis in my replies who had expressed an interest in murdering my family and me.
Thiago Carvalho
boosted
Elon Musk continues his quest to drive everyone away from #Twitter. Be ready for more people joining the #fediverse and #Mastodon.
Thiago Carvalho
boosted
Open rank faculty position in "Microbiome Sciences" at the University of California, Davis in the Department of Medical Microbiology and Immunology (one of my home departments)
Thiago Carvalho
boosted
Drugs that target the Adgrf1 protein may have the potential to alleviate the symptoms of non-alcoholic fatty #LiverDisease in humans. #Medicine https://elifesciences.org/digests/85131/a-new-avenue-for-treating-fatty-liver-disease?utm_source=mastodon&utm_medium=social&utm_campaign=organic
Thiago Carvalho
boosted
So X/Twitter is going to remove their block feature except for DMs. This is crazy.
@Adam_Cadmon1 The French show Into the Night on Netflix.
Thiago Carvalho
boosted
Seems like so-called 'developing' countries are showing the way to address climate change
Would You Vote to Halt Drilling? In Ecuador, They’re Getting the Chance.
Voters decide on Sunday whether the country will ban oil operations in a section of the Amazon that’s one of the most biodiverse places on Earth.
(Paywall is down).
https://www.nytimes.com/2023/08/17/climate/ecuador-yasuni-drilling-referendum.html?unlocked_article_code=dLwGS4re1ZPm0nXWXM9d8fYwj1hbTSzIU0fK0qytaJGr_g5B6rNXkKJtCzDSAzV2AEwrg0JU5_p68a7BoSnA0RRIcL-SV3_AsNT16ttdEt3gStEsaw1MMQQH8bWZS91MbAjREn2beEtvYiIrHjOGcTRtF9Nm4ob4mbBrl1HXyzPRggDNJOiHi64yAOrZ_T83xfrPtxyF7M9yICmLozcPIQlak85aPE-3HhppGlvvpW4irNkhU--7tUhs6p5g4Xohrl5FZLM8dqsuI0jtahYypTTEImYEW8ggpaQ3_Dh2BRLrEh1e9Ii0ITUvGuF9SXUmv1P4ZO0_TIgQtb5IK9zvYI4IeiELACjCuuc1xg&smid=url-share #climateaction #climatechange #ecuador #fossilfuel
"Even more concerning is the idea that content produced by generative AI is polluting the data sets on which future systems will be trained, threatening what some have called “model collapse”. By adding more imperfect information and deliberate disinformation to our knowledge base, generative AI systems are producing a further “enshittification” of the internet, to use Cory Doctorow’s evocative term. This means training sets will spew out more nonsense, rather than less."
https://www.ft.com/content/ed323f48-fe86-4d22-8151-eed15581c337
Thiago Carvalho
boosted
The disinformation machine enabling these threats against the jurors is funded by Republican billionaire donors.
https://www.motherjones.com/politics/2021/01/meet-donald-trumps-top-10-billionaire-enablers/
"In a new study published Thursday in the journal Science, a group of paleontologists that analyzed fossil records at La Brea Tar Pits, a famous excavation site in Southern California, concluded that the disappearance of sabertooth cats, dire wolves and other large mammals in this region nearly 13,000 years ago was linked to rising temperatures and increased fire activity spurred by people."
Thiago Carvalho
boosted
This month's cover accompanies an article about Shared Evolutionary Paths in Social Microbiomes https://doi.org/10.1093/molbev/msad153 #science #evolution #biology #genome #evolgen_paper
"The (re)appreciation that true insight into neural function depends reciprocally on an in-depth understanding of the underlying structure(s) has driven a surge in efforts to develop novel imaging techniques. In fact, keeping track of these approaches, which continue to emerge at a staggering pace, has become a challenge by itself."
#neuroscience @PLOSBiology
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002221
Thiago Carvalho
boosted
Thiago Carvalho
boosted
#Brain activity linked to performing tasks repeats itself during #REMsleep. #Neuroscience #Sleep https://elifesciences.org/digests/84324/learning-in-your-sleep?utm_source=mastodon&utm_medium=social&utm_campaign=organic
Thiago Carvalho
boosted
What can bacteria teach us about unexplored areas of #ubiquitin signaling and regulation?
John Pruneda and colleagues discuss how #pathogens subvert the host cell #ubiquitination system by either adopting or breaking its rules
New review article as #weekendreading!
"Another key parameter in CAR T cell infusion products is the ratio of CD4:CD8 T cell subsets. Yet, it is unclear whether CD4+ and CD8+ CAR T cells have the same propensity to induce CRS. This is particularly relevant since CD4:CD8 ratios can vary extensively in distinct infusion products."
#Immunology #immunotherapy #CARTCells
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(23)00314-2
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
