Thiago Carvalho @cyrilpedia@social.cleverlibre.org

#cardiomastodon @nejm In patients with #heartfailure with preserved ejection fraction & #obesity, #semaglutide (2.4 mg) led to greater reductions in symptoms & physical limitations and greater improvements in exercise function than placebo. Full STEP-HFpEF #clinicaltrial
https://www.nejm.org/doi/pdf/10.1056/NEJMoa2306963?articleTools=true

NYTimes: John Warnock, Inventor of the PDF, Dies at 82
John Warnock, Inventor of the PDF, Dies at 82 https://www.nytimes.com/2023/08/24/technology/john-warnock-dead.html?smid=nytcore-android-share

https://www.sciencedaily.com/releases/2023/08/230815131858.htm

Study explains how part of the nucleolus evolved

#biology #evolution

If you are planning a vacation you may want to call on Chung-Kuei the Chinese god of travel who offers people protection on their journeys. He can scare away demons and evil spirits and keep you safe on your travels. In Japan he is known as Shoki.
#folklore #mythology @folklore @mythology
🎨Utagawa Hiroshige

"UK facing ‘brain drain’ of cancer researchers after failure to join EU scheme"

This piece focuses on principal investigators (i.e., grant holders). The bulk of scientific research work is carrried out by postdocs and other soft-money researchers, and the effect on them of Brexit and the removal of free movement needs addressing.

There appears to be zero political will to finalise UK association to Horizon Europe.

#science #HorizonEurope #FreeMovement #EU #Brexit

https://www.theguardian.com/society/2023/aug/25/uk-facing-brain-drain-of-cancer-researchers-after-failure-to-join-eu-scheme

The Doctoral School of the Faculty of Biology and Medicine in #Lausanne 🇨🇭 offers 3 #PhD Fellowships in Life Science starting April 2024, including in #ecology and #evolution #ecoevo @dee_unil https://www.unil.ch/ecoledoctoralefbm/lang/en/pid/92178

@cyrilpedia Good list. As Fortenberry says (in Complete Science Communication): write like a journalist - talk like a caveman.

Importance of noting all clinical observations, even when not intended -> discovery of metoprolol as an IL-6 antagonist... (well, inhibition of IL-6 translation).

Therapeutic benefit in CAR-T cell-associated cytokine release syndrome (CRS).

Intriguing in vitro effect limited to stimulation by CAR-T lysate & not LPS. Hard to know if experiments really comparable, in terms of timing and stimulus

@JExpMed #immunology #hematology #Science #medicine #Hyperinflammation

https://rupress.org/jem/article/220/11/e20230577/276186/IL-6-translation-is-a-therapeutic-target-of-human?guestAccessKey=14c26a84-b641-4702-bc77-aa191b8e3af1&utm_source=NewJournalContent%27&%27utm_campaign%27=%27JEM%27&%27utm_medium%27=%27Email&nbd=28080031447&nbd_source=campaigner&_ccCt=g843-2py049-cq1cho-cwe4ixj0

Online Now! Chemical reprogramming for cell fate manipulation: Methods, applications, and perspectives https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(23)00284-9?rss=yes&utm_source=dlvr.it&utm_medium=mastodon #stemcells

On this day in 1918: Hans A Krebs born, won 1954 #Nobel Prize for discovering how food molecules get broken down by chemical reactions, #ThisDayInBiotech

24-AUG-2023
Scientists discover a previously unknown way cells break down proteins
The mechanism degrades short-lived proteins that support brain and immune functions
https://www.eurekalert.org/news-releases/998812
a new way of dragging them into the proteasome, to be precise. I assume the proteasome will still digest them the good old way.

#science #nanoworld #proteins #proteasome #biochemistry

Not only are the Saudis mass murdering Ethiopians, but the Ethiopian regime, not content with committing genocide against Tigrayans, is denying that the Saudis are mass murdering Ethiopians. Both KSA and Ethiopia are invited to join the so-called BRICS while the Saudis are literally shooting Ethiopians for sport. Read this.

https://journa.host/@zekuzelalem/110945121388013106

Online Now: Tuning Hsp104 specificity to selectively detoxify α-synuclein https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)00604-4?rss=yes&utm_source=dlvr.it&utm_medium=mastodon

"There is no more open door by which you can enter into the study of natural philosophy than by considering the physical phenomena of a candle."
The Chemical History of a Candle (1860)

Michael Faraday died #OTD in 1867. English physicist and chemist whose many experiments contributed greatly to the understanding of electromagnetism.

Books by Michaeal Faraday at PG:
https://www.gutenberg.org/ebooks/author/5541

#books #science #physics

Podcast: the five episodes of "Avoir raison avec... Karl Polanyi" are now available online
https://www.radiofrance.fr/franceculture/podcasts/serie-avoir-raison-avec-karl-polanyi

Labor’s hypocritical response to the climate crisis is a sad joke on us all https://www.crikey.com.au/2023/08/25/intergenerational-report-labor-climate-crisis/ the title says it all