Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
@andrewplested Let me know if you can place it (I cant).
My first Theroux was when I read the Mosquito Coast as a teenager - and loved it.
Thiago Carvalho
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"New data released Thursday by the National Science Foundation show the exodus of young life scientists from the Ivory Tower to industry has reached the highest level in nearly three decades, deepening concerns about the future of academic science in the U.S....Ph.D. graduates are now pursuing postdocs at the lowest rate since at least 1995, based on STAT’s review of NSF data available online."
https://www.statnews.com/2023/09/28/scientists-exodus-from-academia-historic-levels/
Thiago Carvalho
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Tetraspanins: structure, dynamics, and principles of partner-protein recognition https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(23)00195-2?rss=yes&utm_source=dlvr.it&utm_medium=mastodon
Thiago Carvalho
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Researchers uncover the #neuronal circuits that let fruit fly larvae control their speed and think this mechanism could help us understand #locomotion in other limbed species. #neuroscience #drosophila https://elifesciences.org/articles/83328?utm_source=twitter&utm_medium=social&utm_campaign=organic
Thiago Carvalho
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New paper on how #neuron thresholds modulate function #learning in simple #cerebellum-like networks:
✍️ Marjorie Xie, Samuel P Muscinelli, Kameron Decker, Harris Ashok Litwin-Kumar (2023), Task-dependent optimal representations for cerebellar learning, eLife 12:e82914.
🌍 https://doi.org/10.7554/eLife.82914
“It became the custom in such cases to give credit solely to the one who actually made the experiment work, even if others may have also conceived the idea. It was the drosophilists’ golden rule. Ideas that were engendered in the group’s informal shoptalk were treated as communal resource and not as personal property.”
(Robert E. Kohler, Lords of the Fly)
#Books #Bookshelf #ScienceHistory #SciComm #Drosophila #bookstodon
Thiago Carvalho
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Talmo Pereira (https://talmolab.org/research/) will present a #webinar on "Quantifying #behavior using #DeepLearning"
⏰ October 16, 2023, 16:00 CET
🌍 https://helsinki.zoom.us/meeting/register/u5clcu2qqTstHNyfk9lcMSijYZIS7hXpaNc4#/registration
Thiago Carvalho
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'Here, 273 individuals with or without LC were enrolled in a cross-sectional study that included multi-dimensional immune phenotyping and unbiased machine learning methods to identify biological features associated with LC.'
Thiago Carvalho
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'Un estudio publicado recientemente en la revista BMJ Oncology calcula que la incidencia mundial de tumores entre menores de 50 años ha aumentado un 79% en tres décadas. '
Thiago Carvalho
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"The insecticides used since the 1970s, to spray in houses and on bed nets to protect sleeping children, have become far less effective; mosquitoes have evolved to survive them. After declining to a historic low in 2015, malaria cases and deaths are rising."
https://www.nytimes.com/2023/09/29/health/mosquitoes-malaria-disease-climate-change.html
"Salmonella Typhimurium mutants for spermidine transport and synthesis cannot mount an antioxidative response, resulting in high intracellular ROS levels. These mutants are also compromised in their ability to be phagocytosed by macrophages"
#Microbiology #Preprint #Salmonella #MucosalImmunology #immunology
https://www.biorxiv.org/content/10.1101/2023.09.29.560257v1?med=mas
Merck filed a biologics license application for sotatercept in pulmonary arterial hypertension & now the FDA has granted it priority review.
https://www.merck.com/news/merck-receives-priority-review-from-fda-for-new-biologics-license-application-for-sotatercept-an-activin-signaling-inhibitor-to-treat-adults-with-pulmonary-arterial-hypertension-pah/
I wrote about the drug last fall for Nature Medicine:
"BMPR-II regulates apoptosis and has anti-proliferative effects on pulmonary smooth muscle and endothelial cells. Sotatercept should assist BMPR-II in its tug-of-war with another TGF-beta family member, ActRIIA (which promotes proliferation), by selectively trapping activin pathway ligands. Unlike existing therapies that provide symptomatic management, sotatercept has the potential to be a curative treatment for pulmonary arterial hypertension by modifying the underlying causes of the disease."
Tools
"Natural proteins are composed of 20 proteinogenic amino acids and their post-translational modifications (PTMs). However, due to the lack of a suitable nanopore sensor that can simultaneously discriminate between all 20 amino acids and their PTMs, direct sequencing of protein with nanopores has not yet been realized."
Thiago Carvalho
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The first sentence of Paul Theroux's "The Pillars of Hercules" is still one of my favorites
Thiago Carvalho
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1st of Oct 1990, 33 yrs ago, I stepped into the Genetics Dept to work with Michael Ashburner. Those in the know will realise that the real celebration will be in ~122 days 😎😎
Thiago Carvalho
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There is ‘no limit’, write Nesse and Williams, ‘to the precision and complexity of adaptation that the Darwinian process can generate’.
All hail natural selection!
… unless, of course, the needed mutations fail to occur. #evolution
Thiago Carvalho
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Norway wants Facebook behavioural advertising banned across Europe.
Norway has told the European Data Protection Board (EDPB) it believes a countrywide ban on Meta harvesting user data to serve up advertising on Facebook and Instagram should be made permanent and extended across Europe.
https://www.theregister.com/2023/09/29/norway_facebook_behavioral_ads/
#Europe #Norway #EU #EuropeanDataProtectionBoard #EDPB #Facebook #Meta #Advertising #Privacy
Thiago Carvalho
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I've started a substack! I'll be using it instead of Twitter threads to post about latest Covid situation, latest NHS stats etc.. easier to share here on Mastadon, but more importantly, ensures my content remains *free*!
Next week, I'll be posting about latest Covid situation but also a look back at all the data we *used* to have and common biases in Covid data !
If you've valued what I've been doing on social media, please do subscribe - it's free!
open.substack.com/pub/christin... 1/2
Thiago Carvalho
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'However journal-level metrics fail to identify up to 90% of the equally well-cited papers in the biomedical research literature, controlling for field and year of publication (4). In other words, the recall of the biomedical community’s chosen measure of meritorious papers is on the order of a dismal 10%'
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
