"Although type 1 conventional dendritic cells (cDC1s) were not required for initial priming of CD4+ T cells, cDC1s were required for CD4+ T cell expansion and gut homing. cDC1s were also a major source of IL-12 that was not required for priming but promoted full differentiation of CD4+ T cells and local production of IFN-γ. Together, these studies reveal distinct roles for cDC1s in shaping CD4+ T cell responses to enteric infection: first to drive early expansion in the mesLN and second to drive effector responses in the gut."
#InfectionImmunity #Immunology #MucosalImmunology #parasitology #Preprint
I am actively recruiting students for my lab at UMass Dartmouth!
Are you interested in a project on actin, amoebae, cell migration, and/or pathogenesis? Send me an email & apply to the Integrative Biology PhD program by Jan 15!
Please RT
More info: https://katrinavelle.wixsite.com/science
Meanwhile, in Portugal, no trains & more airports:
"The Socialist Workers' Party of Prime Minister Pedro Sánchez has signed a coalition deal with the far-left Sumar party that includes some 230 policy promises covering the next four years — including a pledge to limit short flights within the country."
https://www.politico.eu/article/spain-aims-to-say-adios-to-short-haul-flights/
"Combining molecular dating, phylogeography, and comparative genomic analyses of a large collection of isolates, we find that several pathogenic lineages of S. suis emerged in the 19th and 20th centuries, during an early period of growth in pig farming. These lineages have since spread between countries and continents, mirroring trade in live pigs."
#InfectiousDisease #zoonosis
Stereotyped goal-directed activity patterns in the insular cortex https://www.biorxiv.org/content/10.1101/2023.11.13.566809v1?med=mas
The formation of a new coalition government in Spain portends big changes for the country's short-haul flights.
The coalition deal includes some 230 policy promises covering the next four years — including a pledge to limit short flights within the country.
The idea is similar to a program in France, and would scrap domestic flights where there is a rail alternative that takes less than two-and-a-half hours
https://www.politico.eu/article/spain-aims-to-say-adios-to-short-haul-flights/
#Spain #ShortHaul #Flights #Aviation #HighSpeedRail #Politics
“Be #sustainable!”
@eosclife assembles recommendations and resources for concrete implementation of #FAIR principles in #lifescience research
https://www.embopress.org/doi/full/10.15252/embj.2023115008
German astronomer and mathematician Johannes Kepler died #OTD in 1630. He is a key figure in the 17th-century Scientific Revolution, and his books Astronomia nova, Harmonice Mundi, and Epitome Astronomiae Copernicanae, influencing among others Isaac Newton, providing one of the foundations for his theory of universal gravitation. The variety & impact of his work made Kepler one of the founders and fathers of modern astronomy, the scientific method, natural and modern science.
Our group has several 3y+ #postdoc openings at the Centre for Organismal Studies at Heidelberg University. Come and join us in Heidelberg to study eye evolution, #cilia, #behaviour by #connetomics #vEM etc. #neuroscience #Evolution #job #science
https://adb.zuv.uni-heidelberg.de/info/INFO_FDB$.startup?MODUL=LS&M1=1&M2=0&M3=0&PRO=34018
"It is very probable that the great stratum called the Milky Way is that in which the sun is placed, though perhaps not in the very centre of its thickness. "
Sir William Herschel: His Life and Works (1880)
as quoted by Edward Singleton Holden via @wikipedia
Books about William Herschel at PG
https://www.gutenberg.org/ebooks/52923
https://www.gutenberg.org/ebooks/29031
'A new venture, led by the founder of a biotech group that was sold to Sanofi for up to $1.45bn in 2021, has won £48mn in funding for research into cancer treatments using machine learning and genetically engineered mouse technology.'
https://www.ft.com/content/73c41613-5fc7-499b-9858-2eeb456014bb
"The prints are very small, some are roughly the size of a stamp, & are at times watercoloured." @madparreira
Mini-etchings inspired by Seghers, Rembrandt & Bruegel the Younger/loosely inspired by 17th century Dutch landscape paintings.
#Print #Printmaking #Etching #Handmade #Art #ArtGallery #artmastodon
"Chronic viral infections are known to accelerate immune aging and to induce immune senescence (21, 22). We have shown that among 206 viruses with human tropism, only CMV seropositivity was associated with senescence of CD8+ T cells in patients with aNSCLC."
#Immunology #TumorImmunology #Immunotherapy
It was an incredible privilege to attend this workshop on cancer immunotherapy organized by Tasuku Honjo & Antonio Coutinho and hosted by the Fondation des Treilles in Provence.
I put together a brief meeting report for the foundation, you can read it here 👇
PostDoc (f/m/d) - Fusion oncogene driven pediatric tumors
St. Anna Children's Cancer Research Institute (St. Anna CCRI)
See the full job description on jobRxiv: https://jobrxiv.org/job/st-anna-childrens-cancer-research-institute-st-anna-ccri-27778-postdoc-f-m-d-fusion-oncogene-driven-pediatric-tumors/?feed_id=65373
#ScienceJobs #hiri...
https://jobrxiv.org/job/st-anna-childrens-cancer-research-institute-st-anna-ccri-27778-postdoc-f-m-d-fusion-oncogene-driven-pediatric-tumors/?feed_id=65373
Where will #InvasiveSpecies go next? Henry Häkkinen @DaveHodgson00 & @ReganEarly provide the first global assessment of regions to which a selection of 833 naturalized #plants, #birds & #mammals could spread (using climate matching, etc) #PLOSBiology https://plos.io/3QGUmlG
An old photo from near the start of my photography career. The enigmatic Nothomyrmecia macrops, a rare ant found only in mallee habitat in South Australia. This species forages on very cold nights along tree trunks to catch insects immobilized by the conditions, and I nearly got hypothermia trying to get this shot.
"While war rages in Gaza, there is also a battle in Israel for the character of our society. That is why we’ve formed the Jewish-Arab Solidarity Network with more than 12 local groups in cities across the country, which works on the ground to combat racism, promote peace and equality, and bring Jewish and Palestinian citizens together"
Uri Weltmann, national field organiser of Standing Together.
#Israel #Palestine #Gaza #Peace #StandingTogether
https://www.theguardian.com/commentisfree/2023/nov/14/grief-racism-israel-peace-palestinians-jews-arabs
"Estas aventuras y aprendizajes infantiles se publicaron en la artesanal revista escolar de Bañuelos de Bureba (Burgos), coordinada por el maestro catalán republicano Antonio Benaiges. Tales andanzas aparecieron en el número de enero de 1936. Faltaban siete meses para que Benaiges fuese apaleado, exhibido por el pueblo y fusilado en el páramo. Lo condenaron sus modernos métodos de enseñanza y lo ajusticiaron los franquistas."
https://elpais.com/espana/2023-11-15/el-pueblo-que-nego-al-maestro-que-prometio-el-mar.html
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com