Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
"Pero, a pesar de estos avances, el conocimiento sobre el sistema inmune sigue siendo limitado y hay cuestiones que aún no se comprenden, admite el neurocientífico Hans Keirstead (Halifax, Canadá, 56 años). El investigador es el CEO del Proyecto del Inmunoma Humano (HIP, por sus siglas en inglés), una iniciativa internacional sin ánimo de lucro que se ha propuesto descodificar ese complejo entramado biológico."
"By 2007, the sea’s surface area had shrunk by around 90 percent, leaving Muynak a landlocked way station for tourists who come to marvel at this ecological disaster, where they take selfies near rusting ship hulks that are perched high and dry in the endless sand."
Photo: Carolyn Drake/Magnum
https://www.nytimes.com/2023/11/28/opinion/climate-uzbekistan-water-aral.html
Thiago Carvalho
boosted
"Although these systems hold great promise for advancing our understanding of lung biology and disease, there are still many challenges, including efficient derivation of terminal cellular maturity and structural complexity, as well as developing standardized workflows for scalability and reproducibility. Here, we outline the most recent developments in lung organoid systems and their implications for disease modeling that could set the stage for further breakthroughs in this exciting and rapidly evolving field."
#Organoids
Thiago Carvalho
boosted
"The non-profit I described was the governing structure that OpenAI began with in 2015, when it was formed as a research-oriented non-profit to build safe AI technology.
But ever since OpenAI’s ChatGPT looked to be on its way to achieving the holy grail of tech – an at-scale consumer platform that would generate billions of dollars in profits – its non-profit safety mission has been endangered by big money."
Thiago Carvalho
boosted
"Congress has an opportunity to turn this ongoing human tragedy into a public health advancement, by providing support for a five-year project to eliminate hepatitis C in the United States. But the time available for approval is growing short."
https://www.nytimes.com/2023/11/28/opinion/hepatitis-c-eliminate.html
Thiago Carvalho
boosted
Karma chamaleon.
Prato falante.
Glazed #stoneware by @hunchbacksociety
#proverbs #proverbios #ceramics #plate #pottery #artgallery #artstagram
Thiago Carvalho
boosted
In his #JEB100 ECR Spotlight Adrien Arias discusses his research journey from #alligators to rats, how #alligators can offer new insights into locomotion & his desire to travel the world and study every animal species.
https://journals.biologists.com/jeb/article/226/22/jeb246994/335477
Thiago Carvalho
boosted
Massively parallel sample preparation for multiplexed single-cell proteomics using nPOP https://www.biorxiv.org/content/10.1101/2023.11.27.568927v1.full.pdf+html
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#proteomics #prot-preprint
Thiago Carvalho
boosted
Austrian mathematician and physicist Christian Doppler was born #OTD in 1803.
Doppler postulated his principle (Doppler effect) that the observed frequency of a wave depends on the relative speed of the source and the observer, and he later tried to use this concept to explain the visible colours of binary stars. Doppler also incorrectly believed that if a star were to exceed 136,000 kilometers per second in radial velocity, then it would not be visible to the human eye.
Thiago Carvalho
boosted
A new #preprint #OpenScience #PeerReview by @PCIEvolBiol: Lluís Socias-Martínez, Louise Rachel Peckre (2023) Does sociality affect evolutionary speed?. Zenodo, ver. 3 peer-reviewed and recommended by Peer Community in Evolutionary Biology. https://doi.org/10.5281/zenodo.10086186 🔽
Thiago Carvalho
boosted
⚠️Do not miss the next PCI webinar of Thursday 7th December on "Interventional #Research on Research to improve the #peerreview process" by Isabelle Boutron. Registration required. #scholarlypublishing #openscience https://peercommunityin.org/pci-webinar-series/
"By employing the SHapley Additive exPlanations (SHAP) values, we sorted the plasma proteins based on their importance in predicting different endpoints. This enabled us to identify the most important discriminators (top 1%) associated with each condition. Some proteins play crucial roles in the prediction of various diseases. Of particular note, the GDF15, which emerged as a robust predictor across all 14 categories of disorders and all-cause mortality and even ranked first among different causes of death and seven specific diseases, namely bacterial infections, anemia, mood disorders, arrhythmias, heart failure, inflammatory bowel disease, and renal failure"
Thiago Carvalho
boosted
The human #OAS1 protein restricts #SARSCoV2 replication, but #HorseshoeBat OAS1 has lost this ability. @spyroslytras @WilsonLabCVR &co resurrect the 60,000,000 yr old ancestral bat OAS1, revealing how this ancient #antiviral mechanism was lost #PLOSBiology https://plos.io/3N6fWPx
Thiago Carvalho
boosted
The @monarch_initiative in 2024: an analytic platform integrating phenotypes, genes and diseases across species https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkad1082/7449493 with Bgee inside, as well as our homology annotations through the Uberon ontology
"For years, Riek and his team have been pursuing the idea that protein-like aggregates, known as amyloids, might have played an important role in the transition between chemistry and biology."
https://phys.org/news/2023-11-molecular-cooperation-threshold-life.html
Thiago Carvalho
boosted
Some good news, folks, on the booster (XBB.1.5). It induces robust levels of neutralizing antibodies vs JN.1
https://biorxiv.org/content/10.1101/2023.11.26.568730v1
All the more reason to get it if you haven't already. JN.1 will likely become dominant here by the holidays
Thiago Carvalho
boosted
Pinched from somewhere else, but this was just too good not to share.
"The storyline, shaped in recent weeks by the testimony of civil servants and scientific advisers, veers between the farcical and the macabre. At the centre of the decision-making web lay an indecisive and “bamboozled” prime minister who struggled with numbers, according to diaries kept by his chief scientific adviser Sir Patrick Vallance."
https://www.ft.com/content/3b606e1d-5515-4670-93e1-348d6d7f506a
"Estabeleceu-se uma igualdade e um paralelismo, puramente inventados, entre o Chega, à direita, e Bloco e PCP à esquerda. Compararam-se propostas de conteúdo racista e xenófobo com propostas de combate às desigualdades sociais e atribuiu-se-lhes a mesma gravidade."
https://www.publico.pt/2023/11/29/opiniao/opiniao/psd-nao-ha-moderacao-ha-desnorte-2071901
Thiago Carvalho
boosted
Postdoctoral Scholar at MD Anderson Cancer Center (Bhattacharya Lab)
The University of Texas MD Anderson Cancer Center
Come join the Bhattacharya Lab at MD Anderson Cancer Center as a postdoc in computational genomics and molecular epidemiology!
See the full job description on jobRxiv: https://jobrxiv.org/job/the-university-of-te...
https://jobrxiv.org/job/the-university-of-texas-md-anderson-cancer-center-27778-postdoctoral-scholar-at-md-anderson-cancer-center-bhattacharya-lab/?feed_id=66500
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
