Thiago Carvalho @cyrilpedia@social.cleverlibre.org

Rhythmic modulation of prediction errors: A top-down gating role for the beta-range in #speechprocessing – new work by Hovsepyan et al. (2023).

🌍 ‪journals.plos.org/ploscompbiol/a…‬

#betaoscillation #sensoryperception #language #modeling

“When people think of how invasive plant species spread, they might assume species are moving because of birds or the wind dispersing seeds,” says Evelyn M. Beaury, lead author of the paper on horticulture & invasive species, as well as a postdoctoral researcher at Princeton who completed this research as an extension to her graduate studies..“But commercial nurseries that sell 100s of different invasives are actually the primary pathway of invasive plant introduction”

https://www.eurekalert.org/news-releases/1010212

#Breaking: In historic decision, FDA approves a CRISPR-based medicine for treatment of sickle cell disease

https://www.statnews.com/2023/12/08/fda-approves-casgevy-crispr-based-medicine-for-treatment-of-sickle-cell-disease/?utm_medium=social&utm_source=mastodon&utm_campaign=mastodon_organic

A comprehensive #SARSCoV2 & #COVID19 review
Part 1: Intracellular overdrive for #SARSCoV2 infection
https://www.nature.com/articles/s41431-022-01108-8.pdf

Although expression of #MDR efflux pump AcrAB-NodT deforms the bacterial envelope, @ViollierPat &co show that homeostatic control by TipR co-induces co-chaperone DjlA, which boosts efflux pump assembly in anticipation of envelope stress #AMR #PLOSBiology https://plos.io/48pzzKX

#Antibody Specificity: A strong case for third-party testing. #Immunology #Biochemistry https://elifesciences.org/articles/93329?utm_source=mastodon&utm_medium=social&utm_campaign=organic_insights

Senior Staff Scientist

FIB-SEM Collaboration Core

Senior Staff Scientist position available in the FIB-SEM Collaboration Core (F-SCC) (https://medicine.yale.edu/fib-sem/) of Yale School of Medicine.

See the full job description on jobRxiv: https://jobrxiv.org/job/fib-sem-collaboration-core-27778-senior-staff-scientist/?feed_id=67221

#biochemistry #bioengineering #bioimaging #Biology #Biotechnol...
https://jobrxiv.org/job/fib-sem-collaboration-core-27778-senior-staff-scientist/?feed_id=67221

The #GPCR CMKLR1 responds to the #adipokine #chemerin and is abundant in #InnateImmune cells. Structure of CMKLR1 in complex with #Gprotein and a peptide agonist (+ mutagenesis & simulations) reveals mechanisms of action #PLOSBiology https://plos.io/4a6Igvd

December 7, 1857, birthday of Belgian-French vertebrate paleontologist Louis Dollo.

An entire herd of Iguanodon fossils discovered in a coal mine near the Belgian town of Bernissart, helped him to reconstruct the anatomy of this dinosaur species. He also found that the "horn" that G. Mantell originally placed on the animal's snout was really a thumb spike 🦖

https://www.strangescience.net/dollo.htm?fbclid=IwAR03miPOcG17KaiAQCsNw1LCnfJIop3q50nvy52naxXJpcrNebaNym0Q7jE

Bispecific T-cell engager targeting DLL3 & CD3

"Tarlatamab, administered as a 10-mg dose every 2 weeks, showed antitumor activity with durable objective responses and promising survival outcomes in patients with previously treated small-cell lung cancer. No new safety signals were identified"
#Immunology #Immunotherapy #LungCancer

https://www.nejm.org/doi/full/10.1056/NEJMoa2307980?query=featured_home

“El caso es que esos hematófagos se extinguieron, y no sabemos por qué. Tal vez hubo más recursos para la hematofagia durante el cretácico temprano y luego los recursos disminuyeron o la competencia entre moscas hematófagas llevó a la extinción de los taxones menos adaptados”

https://elpais.com/ciencia/2023-12-04/unos-mosquitos-atrapados-en-ambar-hace-130-millones-de-anos-demuestran-que-los-machos-tambien-chupaban-la-sangre.html

“For years the EU has been trying to agree on a new system to respond to people moving or fleeing to Europe. The agreement now on the table would in many ways worsen existing legislation, and risks increasing suffering at European borders.”

https://www.theguardian.com/world/2023/dec/06/eu-migration-package-risks-racial-profiling-and-discrimination-ngos-say

'Virus-based vectors — particularly those based on adeno-associated virus (AAV) and lentiviruses — have dominated the first wave of gene therapies to gain regulatory approval. But their widespread deployment in dozens of clinical trials has exposed their limitations.'

https://www.nature.com/articles/s41587-023-01824-6

"This article is dedicated to researchers who aspire to more than just a temporary solution for data analysis. It's for those who are committed to developing a deeper understanding and proficiency in bioinformatics."

https://network.febs.org/posts/navigating-bioinformatics-a-self-learning-guide-for-wet-lab-scientists

Laughing Kookaburra, Stradbroke Island, Queensland.