Thiago Carvalho @cyrilpedia@social.cleverlibre.org

"To build a comprehensive hemocyte single-cell atlas of larval hemocytes, we integrated whole transcriptomes of hemocytes both in circulation and in the lymph gland 72, 96, and 120 hours after egg laying"

https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011077

"Irreproducible experiments, projects that failed to meet their goals, datasets we collected but never managed to analyze, and freezers full of unusable samples have taught us the hard way lessons that have led to these 10 simple rules for managing laboratory information."

https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011652

"Among​ the enduring riddles of American exceptionalism is the absence in the political mainstream of an overtly socialist party. Whereas in Europe socialist and social democratic parties emerged to tame the excesses of private enterprise, the much rawer, more carelessly exploitative forms of capitalism found in the United States failed to provoke a political response of a similar character or on anything like the same scale. The paltry 6 per cent of the popular vote won in the 1912 election by Eugene Debs remains the best performance by a Socialist Party presidential candidate."

https://www.lrb.co.uk/the-paper/v46/n01/colin-kidd/antidote-to-marx

Cómo se comunican los animales

Una mancha oscura en el vientre de un ciervo macho, el sonido que emiten las cigüeñas al chocar entre sí las dos partes de su pico o el olor que ciertos animales territoriales liberan en su orina son señales que transmiten un mensaje. Ya sea por supervivencia o para reproducirse, los animales se comunican. Pero, ¿siempre lo hicieron con las mismas estrategias?

http://lasendadeapolo.es/2023/12/29/como-se-comunican-los-animales/

Aglaonice or Aganice of Thessaly was a Greek astronomer and thaumaturge of the 2nd or 1st century BC.

She is mentioned in the writings of Plutarch and Apollonius of Rhodes as the daughter of Hegetor of Thessaly or as the daughter of Hegemon. She was regarded as a sorceress for her ability to make the moon disappear from the sky, which has been taken to mean she could predict the time and general area where a lunar eclipse would occur.

#science #astronomy #womeninscience

Polly Dips Her Crackers In Water, Like People Dipping Theirs In Coffee | University of Vienna & University of Veterinary Medicine Vienna, published by Royal Society Publishing Biology Letters

by @GrrlScientist

#parrots🦜 #ornithology #innovation #food #SciComm🧪 https://www.forbes.com/sites/grrlscientist/2023/12/29/polly-dips-her-crackers-in-water-like-people-dipping-theirs-in-coffee/

"La Agencia Europea del Medicamento (EMA, en sus siglas en inglés) ha decidido suspender la comercialización en la UE de cientos de fármacos genéricos al tener dudas sobre la credibilidad de los datos de los ensayos clínicos que los respaldan, realizados en India por la empresa Synapse Labs."

https://elpais.com/sociedad/2023-12-27/la-ema-suspende-la-venta-de-cientos-de-farmacos-genericos-por-dudas-sobre-la-fiabilidad-de-los-ensayos-clinicos.html

"JN.1, which emerged from the variant BA.2.86 and was first detected in the United States in September, accounted for 44 percent of Covid cases nationwide by mid-December, up from about 7 percent in late November, according to data from the Centers for Disease Control and Prevention."

https://www.nytimes.com/2023/12/27/well/live/jn1-covid-variant.html

"Greta Livraria’s small space masks its big ambitions. Since opening earlier this year, the bookstore in Lisbon has dedicated its space entirely to promoting a group that has, for the most part, been overlooked and undervalued by society: female authors."

https://www.theguardian.com/books/2023/dec/28/historical-reparation-new-bookshops-europe-give-voice-female-authors

This post deserves a Pulitzer Prize.

The author (not on Mastodon) describes it as "covering the history of the pharma industry, why drugs cost orders of magnitude more to develop now than in the 50s, and some suggestions on what we can do to improve R&D efficiency."

It's thoughtful, nuanced, packed with actionable suggestions, and yet written to be approachable for a general audience. Highly recommended!
https://atelfo.github.io/2023/12/23/biopharma-from-janssen-to-today.html

Wow, that’s a great overview of the history and challenges of drug development. The references alone are incredibly useful - thanks for sharing!

From: @predrag
https://hachyderm.io/@predrag/111662075123530020

Online Now: p300 is an obligate integrator of combinatorial transcription factor inputs https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)01023-7?rss=yes&utm_source=dlvr.it&utm_medium=mastodon

China braces for Covid surge as JN.1 variant spreads around the world

“[The rise in JN.1 cases] will increase the risks of severe cases and deaths among elderly and vulnerable people with underlying diseases.

https://www.scmp.com/news/china/science/article/3246709/china-braces-covid-surge-jn1-variant-spreads-around-world