Thiago Carvalho @cyrilpedia@social.cleverlibre.org

"But in case you want to be more precise, let’s examine how enshittification works. It’s a three-stage process: first, platforms are good to their users. Then they abuse their users to make things better for their business customers. Finally, they abuse those business customers to claw back all the value for themselves. Then, there is a fourth stage: they die."

https://www.ft.com/content/6fb1602d-a08b-4a8c-bac0-047b7d64aba5

Flow cytometry primer.

*NB: One person's debris are another person's exosomes :)
"First, SSC and FSC are measured to differentiate cells from debris."

https://blog.addgene.org/antibodies-101-reading-a-flow-plot

"I started working on ants in 2001 when I joined Bert Hölldobler’s department at the University of Würzburg as an undergrad, and I’ve never looked back. Initially, I wanted to become a tropical ecologist but then pivoted toward evolutionary biology and population genetics. Fast forward a few years and I’m giving an interview to Neuron, which I guess means I have now become a neurobiologist. Still studying ants of course."

https://www.cell.com/neuron/fulltext/S0896-6273(24)00035-7

'The best piece of advice I've had was from John Wallingford, and it was simple: “Read and learn how to write.” Learning how to write will save you a lot of time in a scientific or research career. Writing fast, writing well, writing clearly and concisely in a way makes people excited about your research – this is a skill that will definitely make your life easier.'

https://journals.biologists.com/jcs/article/137/3/jcs261929/342718/Cell-scientist-to-watch-Jakub-Sedzinski

From Eugene Koonin et al:

"The Last Archaeal Common Ancestor likely encompassed a complex ESCRT system that was involved in protein sorting. Subsequent evolution involved either simplification, as in the TACK superphylum, where ESCRT was co-opted for cell division, or complexification as in Asgardarchaeota. In Asgardarchaeota, the connection between ESCRT and the ubiquitin system that was previously considered a eukaryotic signature was already established."
#Preprint #Archaea #Evolution

https://www.biorxiv.org/content/10.1101/2024.02.06.579148v1

The art of war:

"Pulling from cancer’s playbook, Roybal and his colleagues incorporated 71 mutations, found in cancerous T cells, into CAR T cells. When they looked at how these perturbations affected T-cell function, one mutation stood out. The CAR T cells carrying an aberrant protein dubbed CARD11–PIK3R3 infiltrated well into tumours and had long-lasting cancer-killing activity."
#Immunology #immunotherapy #CARTcells

https://www.nature.com/articles/d41586-024-00305-3

“Child deaths are rising, infant survival lags behind comparable countries, and preventable physical and mental health issues plague our youngest citizens,” said Professor Helen Minnis, co-chair of the report and an academic at Glasgow university.'
#publichealth

https://www.ft.com/content/ef9231b4-e997-4f5b-afd2-b5f2864ac699

Magrolimab is an anti-CD47

'Gilead Sciences, Inc. today announced it has discontinued the Phase 3 ENHANCE-3 study of magrolimab in AML and that the (FDA) placed all magrolimab studies in myelodysplastic syndromes and AML, including related expanded access programs, on full clinical hold'
#Leukemia #ClinicalTrial #CD47 #Hematology

https://www.gilead.com/news-and-press/company-statements/gilead-statement-on-discontinuation-of-phase-3-enhance-3-study-in-aml

'Dados do Ministério da Saúde do Brasil indicam que o país registou 345.235 casos prováveis de dengue este ano, com 36 mortes e outras 234 em investigação. O número de casos triplicou entre os dias 21 e 27 de janeiro, comparando com o mesmo período do ano passado.'
#Dengue

https://expresso.pt/internacional/brasil/2024-02-07-Dengue-no-Brasil-este-ano-ja-se-registaram-mais-de-300-mil-casos-provaveis-Governo-diz-que-e-hora-do-pais-se-unir-702a0d7f