Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
Looking for a #job in #academia in #ecology & #Evolution ?
Follow this group:
▶️ @jobsecoevo ◀️
PS1: IF you were following the group @joboffersecoevo, I recommend you unfollow it - as we'll be using the new group - with a simpler name - instead
PS2 - to receive future job adverts, follow THE GROUP not me! 🙃
Thiago Carvalho
boosted
Children in iron lung (1937) before the advent of the polio vaccine. The iron lung is a mechanical respirator that enables a person to breathe when muscle control is lost.
In the first half of the 20th century, polio was the leading cause of death in children and young adults. In extreme cases, the virus can cause spinal and respiratory paralysis, making it impossible to breathe. The iron lung saved countless lives. #vaccines #histmed #medhist #histodons #history #MedMastodon #ScienceMastodon
Thiago Carvalho
boosted
Our prospective Paxlovid rebound study with controls preprint is posted
By symptoms: ~12% rebound (19% Pax vs 7% controls)
By positive testing: ~5% rebound (14% Pax vs 9% controls)
Much lower than many estimates
https://www.medrxiv.org/content/10.1101/2022.11.14.22282195v1 by @JayPandit@twitter.com @michaelmina_lab@twitter.com @ScrippsRTI@twitter.com
#Telomeres #Telomerase #tumorigenesis #Preprint from Charles Kinzig, Titia de Lange et al
"Here, we aimed to determine whether telomerase can add telomeric DNA to DSBs in human cells and how this process is regulated. The data indicate that telomerase can create a functional neotelomere at a Cas9-induced DSB that bears the TS sequence at one 3′ end. The frequency of neotelomere formation is increased upon overexpression of telomerase, suggesting that the low level of telomerase in most human cells minimizes these deleterious events. In addition, neotelomere formation is inhibited by ATR signaling at resected DSBs. We discuss these findings in the context of genome instability during tumorigenesis, where neotelomere formation by telomerase might end BFB cycles as originally proposed by McClintock."
Thiago Carvalho
boosted
The miracle of insect metamorphosis appears to be brought on, in part, by a revival of gene transcription from the egg/embryonic stage.
This strikes me as a significant advance in our understanding of insect biology.
"It was late in 1972 — a year in which the science of genetic engineering really began to sizzle — that two California researchers announced the unusually tidy transfer of genetic information from one bacterium to another with help from a specialized enzyme. It was a scientifically heralded result, but behind the hoopla was just one small catch. The information transferred enabled a common human disease bacterium, E. coli, to resist not just one antibiotic, but two.
“Alarm bells should have rung,” writes @matthewcobb, in his deeply researched and often deeply troubling history of gene science."
https://www.nytimes.com/2022/11/14/books/review/as-gods-matthew-cobb.html
Thiago Carvalho
boosted
Job: PhD in disease ecology USA
#job #PhD #diseaseecology
#birds
In Tucson, #USA
Deadline 1 Dec 2022
More info: https://twitter.com/SabrinaMcnew/status/1591175329619800064
Thiago Carvalho
boosted
What if we could map the #genome, #transcriptome, and #proteome at single-cell spatial resolution across entire organs?
In this very nice review article, Jeffrey Moffitt et al. provide a comprehensive overview of the emerging landscape of #spatialprofiling technologies.
Article in Nature Reviews #Genetics: https://www.nature.com/articles/s41576-022-00515-3
#histology #pathology #multiomics #artificialintelligence #machinelearning
Thiago Carvalho
boosted
RT @HHMIJanelia@twitter.com
🚨 One week left 🚨
Applications for Group Leader & Sr. Group Leader positions in 🦠 4D Cellular Physiology, 🧠 Mechanistic Cognitive Neuroscience and 🖥️ Computation & Theory close Nov. 22.
Apply today ▶️ https://www.janelia.org/our-research/our-labs/group-leaders
🐦🔗: https://twitter.com/HHMIJanelia/status/1592540182896869376
Thiago Carvalho
boosted
My migration to Mastodon is complete! I deleted my Twitter account. I am an Associate Professor at The University of Washington. My interests are innate immunity, host-virus interactions, RNA regulation and host genetics. I am looking forward to interacting with everyone! #RNA #hostpathogeninteractions #immunology
Thiago Carvalho
boosted
I’m looking for grad students for 2023. Projects related to cell-free placental DNA dynamics, (Epi)genomics, and placental dysfunction. Projects are computational. See website for details about lab, also pls RT (http://wilsonpregnancylab.com)
@IFPA_Official @SRIWomensHealth
@CEEHRC
Thiago Carvalho
boosted
This post has all the relevant links and review the recent its for protection vs #LongCovid
https://erictopol.substack.com/p/paxlovid-and-long-covid
Thiago Carvalho
boosted
📢 📢New lab preprint!!! Check out @louvel_vincent 's work, he pushed expansion microscopy to SMLM-like resolution by optimizing U-ExM and interative expansion. Check out this thread to learn more👇
---
RT @louvel_vincent
Thrilled to present my PhD work about the development of #iUExM 🥳
Here, we introduce an optimized versatile protocol using iterative expansion to reach #SMLM resolution on conventional widefield or confocal fluorescen…
https://twitter.com/louvel_vincent/status/1592517504475492353
Thiago Carvalho
boosted
Retweeting this for our friends across the pond.
Info & registration at the course website below.
Registration deadline is
March 31, 2023.
Join us as we speculate about the future of evo-devo with a fantastic panel of teachers & an innovative teaching format.
#VeniceEvoDevo
---
RT @VeniceEvoDevo
VENICE SUMMER SCHOOL 2023
The future of evo-devo
Aug 21-25, 2023
Centro Culturale Don Orione Artigianelli, Venice
The course website …
https://twitter.com/VeniceEvoDevo/status/1592437106567151616
Thiago Carvalho
boosted
Nice study showing Candida albicans lipase suppressing host IL-17 responses & promotes invasive infection.
Caveats re model systems used, etc.. but interesting demonstration of pathogen evasion of protective host immune responses.
#mycology #immunology #IDMastodon #Science #IL17 #Candida
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(22)00517-0#secsectitle0070
Thiago Carvalho
boosted
Trying to follow the rule of listening for at least a week before posting...so here's an #introduction
I grew up in East TN as a National Lab kid. Studied philosophy and language in college, briefly a short order cook in New Orleans. I fell into the open web after answering a Boston Globe classified ad in 1998 and am really interested in how data, science, governance, and computers intersect.
As an old man, my interests include knee pain, kid swim meets, and wondering where the remote is.
"Before 2020, respiratory syncytial virus (#RSV) and non-pandemic #influenza viruses peaked in the winter in northern and southern hemispheres outside of tropical areas. In temperate climates, non-polio enteroviruses circulated in the summer to autumn in cyclical patterns. The #COVID19 pandemic has led to a departure from these patterns and, in many locations, usual circulation of these viruses was absent for more than a year only to resurge in unexpected ways."
Thiago Carvalho
boosted
Last chance to apply for our Wellcome Trust 4-year PhD programme in ‘Advanced Therapies for Regenerative Medicine’ at King's College London
🧫🎓🧪🧬
#stemcells #devbiol #PhD #science #bioengineering
@RegenMedPhD
Closing date in 2 DAYS THURSDAY Nov 17!
⤵️
https://regenerativemedicinephd.co.uk/apply
"The rate at which human sperm counts are decreasing has more than doubled since the turn of the century, and the mean level has dropped below a threshold that makes conception significantly more difficult.
These findings are part of a new peer-reviewed study published today in the Human Reproduction Update journal that includes data from 53 countries and is the first meta-analysis to check levels in Central America, South America and Asia."
https://www.theguardian.com/science/2022/nov/15/global-human-sperm-count-decrease-doubled
Thiago Carvalho
boosted
RT @JBiogeography@twitter.com
To celebrate the 60th anniversary of MacArthur & Wilson (1963) and 50th volume of the Journal of Biogeography we invite papers for a special issue on Functional Island Biogeography: the study of island communities from the perspective of their traits https://onlinelibrary.wiley.com/journal/13652699/homepage/callforpapers-functional-island
🐦🔗: https://twitter.com/JBiogeography/status/1592371742244118529
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
